Jump to ContentJump to Main Navigation

Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

10 Issues per year

IMPACT FACTOR 2014: 2.492
5-year IMPACT FACTOR: 3.202
Rank 51 out of 157 in category Chemistry, Multidisciplinary in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.012
Source Normalized Impact per Paper (SNIP) 2014: 1.187
Impact per Publication (IPP) 2014: 2.785



The deoxyxylulose phosphate pathway of isoprenoid biosynthesis. Discovery and function of the ispDEFGH genes and their cognate enzymes

F. Rohdich1 / Stefan Hecht1 / Adelbert Bacher1 / Wolfgang Eisenreich1

1Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstraße 4, D-85747 Garching, Germany


IUPAC International Symposium on the Chemistry of Natural Products, International Symposium on the Chemistry of Natural Products, ISCNP, Natural Products, 23rd, Florence, Italy, 2002-07-28–2002-08-02

Citation Information: Pure and Applied Chemistry. Volume 75, Issue 2-3, Pages 393–405, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200375020393, January 2009

Publication History

Published Online:

Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) serve as the universal precursors for the biosynthesis of terpenes. Besides the well-known mevalonate pathway, a second biosynthetic pathway conducive to IPP and DMAPP via 1-deoxy-d-xylulose-5-phosphate and 2C-methyl-d-erythritol-4-phosphate has been discovered recently in plants and certain eubacteria. 2C-Methyl-d-erythritol-4-phosphate, the first committed intermediate of the deoxyxylulose phosphate pathway, is converted into 2C-methyl-d-erythritol 2,4-cyclodiphosphate by the catalytic action of three enzymes specified by the ispDEF genes. The cyclic diphosphate is reductively opened by the IspG protein affording 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate. This compound can be converted into IPP as well as DMAPP by the catalytic action of IspH protein. The enzymes of this pathway are potential targets for novel antibacterial, antimalarial, and herbicide agents.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Felix Quitterer, Annika Frank, Ke Wang, Guodong Rao, Bing O'Dowd, Jikun Li, Francisco Guerra, Safwat Abdel-Azeim, Adelbert Bacher, Jörg Eppinger, Eric Oldfield, and Michael Groll
Journal of Molecular Biology, 2015, Volume 427, Number 12, Page 2220
Tiziana Masini and Anna K. H. Hirsch
Journal of Medicinal Chemistry, 2014, Volume 57, Number 23, Page 9740
S. Heuston, M. Begley, C. G. M. Gahan, and C. Hill
Microbiology, 2012, Volume 158, Number Pt_6, Page 1389
Tobias Gräwert, Michael Groll, Felix Rohdich, Adelbert Bacher, and Wolfgang Eisenreich
Cellular and Molecular Life Sciences, 2011, Volume 68, Number 23, Page 3797
Chai-lin Kao, William Kittleman, Hua Zhang, Haruo Seto, and Hung-wen Liu
Organic Letters, 2005, Volume 7, Number 25, Page 5677
Xihou Yin and Philip J Proteau
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003, Volume 1652, Number 1, Page 75
Worapan Sitthithaworn, Juraithip Wungsintaweekul, Tanawan Sirisuntipong, Tossaton Charoonratana, Yutaka Ebizuka, and Wanchai De-Eknamkul
Journal of Plant Physiology, 2010, Volume 167, Number 4, Page 292
Youli Xiao, Lisa Chu, Yiannis Sanakis, and Pinghua Liu
Journal of the American Chemical Society, 2009, Volume 131, Number 29, Page 9931
Tobias Gräwert, Ingrid Span, Adelbert Bacher, and Michael Groll
Angewandte Chemie International Edition, 2010, Volume 49, Number 47, Page 8802
T. Grawert, I. Span, W. Eisenreich, F. Rohdich, J. Eppinger, A. Bacher, and M. Groll
Proceedings of the National Academy of Sciences, 2010, Volume 107, Number 3, Page 1077
Mads Gabrielsen, Felix Rohdich, Wolfgang Eisenreich, Tobias Gräwert, Stefan Hecht, Adelbert Bacher, and William N. Hunter
European Journal of Biochemistry, 2004, Volume 271, Number 14, Page 3028
Anna K. H. Hirsch, François Diederich, Markus Antonietti, and Hans G. Börner
Soft Matter, 2010, Volume 6, Number 1, Page 88
Youli Xiao and Pinghua Liu
Angewandte Chemie International Edition, 2008, Volume 47, Number 50, Page 9722
Rachel Davidovich-Rikanati, Efraim Lewinsohn, Einat Bar, Yoko Iijima, Eran Pichersky, and Yaron Sitrit
The Plant Journal, 2008, Volume 56, Number 2, Page 228
Anna K. H. Hirsch, Magnus S. Alphey, Susan Lauw, Michael Seet, Luzi Barandun, Wolfgang Eisenreich, Felix Rohdich, William N. Hunter, Adelbert Bacher, and François Diederich
Organic & Biomolecular Chemistry, 2008, Volume 6, Number 15, Page 2719
Christine M. Crane, Anna K. H. Hirsch, Magnus S. Alphey, Tanja Sgraja, Susan Lauw, Victoria Illarionova, Felix Rohdich, Wolfgang Eisenreich, William N. Hunter, Adelbert Bacher, and François Diederich
ChemMedChem, 2008, Volume 3, Number 1, Page 91
Christine M. Crane, Johannes Kaiser, Nicola L. Ramsden, Susan Lauw, Felix Rohdich, Wolfgang Eisenreich, William N. Hunter, Adelbert Bacher, and François Diederich
Angewandte Chemie, 2006, Volume 118, Number 7, Page 1082
Anna K. H. Hirsch, Felix R. Fischer, and François Diederich
Angewandte Chemie International Edition, 2007, Volume 46, Number 3, Page 338
Anna K. H. Hirsch, Susan Lauw, Philipp Gersbach, W. Bernd Schweizer, Felix Rohdich, Wolfgang Eisenreich, Adelbert Bacher, and François Diederich
ChemMedChem, 2007, Volume 2, Number 6, Page 806
Michelle C Y Chang and Jay D Keasling
Nature Chemical Biology, 2006, Volume 2, Number 12, Page 674
Lorenzo Carretero-Paulet, Albert Cairó, Patricia Botella-Pavía, Oscar Besumbes, Narciso Campos, Albert Boronat, and Manuel Rodríguez-Concepción
Plant Molecular Biology, 2006, Volume 62, Number 4-5, Page 683

Comments (0)

Please log in or register to comment.