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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report)

Giorgio Anderegg1 / Francoise Arnaud-Neu2 / Rita Delgado3 / Judith Felcman4 / Konstantin Popov5

1Laboratory of Inorganic Chemistry, Swiss Federal Institute of Technology, ETH, Wolfgang Pauli Strasse 10, CH 8093 Zürich, Switzerland

2Laboratoire de Chimie-Physique, UMR 7512 (CNRS-ULP), ECPM, 25, rue Becquerel, 67087 Strasbourg Cédex 02, France

3Instituto de Tecnologia Química e Biológica (ITQB), Apartado 127, 2781-901 Oeiras, Portugal and Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

4Pontificia Universidade Católica do Rio de Janeiro, Rua Marques de São Vicente 225-Gávea, 22453-900 Rio de Janeiro-RJ, Brazil

5Institute of Reagents and High Purity Substances (IREA), Bogorodsky val-3, 107258, Moscow, Russia and Moscow State University of Food Production, Volokolamskoye Sh. 11, 125080 Moscow, Russia

Project Year: 2001, Project Code: 2001-055-1-500

Citation Information: Pure and Applied Chemistry. Volume 77, Issue 8, Pages 1445–1495, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200577081445, January 2009

Publication History

Published Online:

Available experimental data on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid [2,2'-azanediyldiacetic acid, IDA], (methylimino)diacetic acid [2,2'-(methylazanediyl)diacetic acid, MIDA]; 2,2',2'',2'''-{[(carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]}tetraacetic acid (DTPA), 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2',2''-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA); 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA); 2,2',2'',2'''-(1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid (TETA), published in 1945-2000, have been critically evaluated. Some typical errors in stability constant measurements for particular complexones are summarized. Higher quality data are selected and presented as “Recommended” or “Provisional”.

Keywords: biomedical; Complexones; Division V.; environmental; metal complexes; proton complexes; stability constants

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