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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

12 Issues per year

IMPACT FACTOR 2013: 3.112
Rank 41 out of 148 in category Multidisciplinary Chemistry in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 1.172
Source Normalized Impact per Paper (SNIP): 1.106



Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology

Tzahi Cohen-Karni1 / Charles M. Lieber3

1Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA

2David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA

3Department of Chemistry and Chemical Biology, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

Citation Information: Pure and Applied Chemistry. Volume 85, Issue 5, Pages 883–901, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/PAC-CON-12-10-19, April 2013

Publication History

Published Online:

The interface between nanoscale electronic devices and biological systems enables interactions at length scales natural to biology, and thus should maximize communication between these two diverse yet complementary systems. Moreover, nanostructures and nanostructured substrates show enhanced coupling to artificial membranes, cells, and tissue. Such nano–bio interfaces offer better sensitivity and spatial resolution as compared to conventional planar structures. In this work, we will report the electrical properties of silicon nanowires (SiNWs) interfaced with embryonic chicken hearts and cultured cardiomyocytes. We developed a scheme that allowed us to manipulate the nanoelectronic to tissue/cell interfaces while monitoring their electrical activity. In addition, by utilizing the bottom-up approach, we extended our work to the subcellular regime, and interfaced cells with the smallest reported device ever and thus exceeded the spatial and temporal resolution limits of other electrical recording techniques. The exceptional synthetic control and flexible assembly of nanowires (NWs) provides powerful tools for fundamental studies and applications in life science, and opens up the potential of merging active transistors with cells such that the distinction between nonliving and living systems is blurred.

Keywords: biotechnology; nano–bio interfaces; nanowires; synthesis

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