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Polish Journal of Surgery
The Journal of Foundation of the Polish Journal of Surgery
SCImago Journal Rank (SJR) 2015: 0.214
Source Normalized Impact per Paper (SNIP) 2015: 0.336
Impact per Publication (IPP) 2015: 0.443
Very High Concentration of D-Dimers in Portal Blood in Patients with Pancreatic Cancer
1Department of General and Transplant Surgery, Medical University in Łódź, Barlicki University Hospital in Łódź
2Department of Anaesthesiology and Intensive Therapy, Barlicki University Hospital in Łódź
This content is open access.
Citation Information: Polish Journal of Surgery. Volume 84, Issue 10, Pages 521–525, ISSN (Online) , ISSN (Print) 0032-373X, DOI: 10.2478/v10035-012-0087-z, December 2012
- Published Online:
The aim of the study
Nowadays, increasing attention has been focused on relation between increased D-dimer levels and cancer among patients without detectable thrombosis.
was to measure plasma D-dimer levels in portal and peripheral blood in pancreatic cancer patients with absence of venous thromboembolism.
Material and methods. Fifteen consecutive patients hospitalized in the Department of General and Transplant Surgery of Medical University in Łódź, from January to March 2012 who underwent surgery due to a pancreatic cancer were enrolled. At laparotomy, portal and peripheral blood were sampled concurrently. D-dimer and fibrinogen levels were measured. Moreover, to investigate overall coagulation function prothrombin time (PT), prothrombin index (PI), international normalized ratio (INR), thrombin time (TT), activated partial thromboplastin time (APTT), TT and APTT index were evaluated.
Results. Peripheral plasma D-dimmer levels above normal range were found in 10/15 patients (66,67%), whereas D-dimer above normal values were confirmed in all portal blood samples. Mean D-dimer values were higher in portal than in peripheral blood (3279.37 vs 824.64, by 297%, p=0,025). These discrepancies were accompanied by normal limits of portal and peripheral levels of fibrinogen and comparable coagulation function indexes.
Conclusion. Our preliminary study showed the close relation between activation of hemostasis, reflected by elevated D-dimers in portal blood and presence of pancreatic cancer. These data suggest that measurement of portal blood D-dimer levels may be a potentially useful technique for screening the pancreatic cancer.