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Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

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The application of circulating tumor cells detecting methods in veterinary oncology

12 / K. Łosiewicz2 / P. Socha3 / T. Męcik-Kronenberg4 / K. Wąsowicz2

1Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13 Bldg. 105J, 10-719 Olsztyn, Poland

2Department of Pathophysiology, Forensic Veterinary and Administration, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland

3Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland

4Department of Pathology in Zabrze, Medical University of Silesia, 3 Maja 13/15, 41-800 Zabrze, Poland

This content is open access.

Citation Information: Polish Journal of Veterinary Sciences. Volume 16, Issue 1, Pages 141–151, ISSN (Print) 1505-1773, DOI: 10.2478/pjvs-2013-0022, May 2013

Publication History

Published Online:
2013-05-21

Abstract

Cancers are one of the most common diseases affecting dogs. Many of them develop spontaneously and their biology and histopathology shows many similarities to human cancers. What more, it is proved that there are much more analogies in molecular mechanisms of cancer development between these two species. Human oncology is seeking more and more efficient methods for an early disease detection which results directly in the extended life expectancy of patients affected. One of the most modern trends in the diagnosis of cancer is to detect circulating tumor cells (CTC) in the blood of patients. It is known that these cells are responsible for the formation of metastases in distant organs what results in the patient death. Moreover, it’s confirmed that CTC are already present in patients’ bloodstream in the early stages of tumor development. There is no doubt that mechanism of metastasis development in dogs is identical and thus the CTC are also present in their bloodstream. Despite the intense researches there is still no optimal method of isolating cancer cells from the blood where they occur extremely rarely. The purpose of this study is to analyze the implications of the detection methods of tumor cells in the blood in veterinary oncology.

Keywords: circulating tumor cells; cancer; metastasis; dog

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