Jump to ContentJump to Main Navigation

Polish Psychological Bulletin

The Journal of Committee for Psychological Sciences of Polish Academy of Sciences

4 Issues per year

Open Access
VolumeIssuePage

Issues

Open Access

In vitro fertilization (IVF) and the risk of birth and developmental defects - facts and fictions

Barbara Dolinska1

Department of Psychology, Wroclaw University, Poland1

This content is open access.

Citation Information: Polish Psychological Bulletin. Volume 40, Issue 3, Pages 145–155, ISSN (Print) 0079-2993, DOI: 10.2478/s10059-009-0027-x, July 2010

Publication History

Published Online:
2010-07-29

In vitro fertilization (IVF) and the risk of birth and developmental defects - facts and fictions

Poland is being swept by a wave of discussions on various aspects of IVF application. Scientists of various disciplines are getting involved in these discussions as opponents to this form of procreation. Referring to research carried out all over the world, they demonstrate that children born thanks to the in vitro procedure are significantly more susceptible to all sorts of disease. The author, surveying available research data, shows that, in reality, the worse health of in vitro-conceived children deals with a narrow number of well-identified disorders and in most cases is of correlative, not causative nature. The main reason for the weaker health of these children is often connected with the advanced age of the parents who choose IVF and their health condition (mothers' in particular), as compared to those who become parents in a natural way.

Keywords: Birth; developmental defects; IVF

  • Amor, D. J. & Halliday, J. (2008) A review of known imprinting syndromes and their association with assised reproduction technologies. Human Reproduction, 23, 2826-2834. [CrossRef]

  • Anthony, S., Buitendijk, S. E., Dorrepaal, C. A., Lindner, K., Braat, D. D. M. & den Ouden, A. L. (2002) Congenital malformations in 4224 children conceived after IVF. Human Reproduction, 17, 2089-2095. [CrossRef]

  • Babuchowski, S. (2008) Niebezpieczne in vitro. Gość Niedzielny, 4.

  • Barnes, J., Sutcliffe, A. G., Kristoffersen, I., Loft, A., Wennerholm, U., Tarlatzis, B. C., Kantaris, X., Nekkebroeck, J., Hagberg, b.S., Madsen, S. V. & Bonduelle, M. (2004). The influence of assisted reproduction on family functioning and children's socio-emotional development: results from a European study. Human Reproduction, 19, 148-1487.

  • Belva, F., Henriet, S., Liebaers, I., Van Steirteghem, A., Celestin-Westreich, S., Bonduelle, M. (2007). Medical outcome of 8-year-old singleton ICSI children (born ≥32 weeks' gestation) and a spontaneously conceived comparison group. Human Reproducion, 22, 506-515.

  • Bergh, T., Ericson, A., Hillensjo, T., Nygren, K. G. & Wennerholm, U. B. (1999). Deliveries and children born after in-vitro fertilization in Sweden 1982-95: a retrospective cohort study. Lancet, 354,1579-1585.

  • Bielak, A., Hińcz, P., Brot, A., Wilczyński, J. (2003). Przebieg ciαzy i porodu po IVF-ET u pacjentek hospitalizowanych w klinice Medycyny Matczyno — Plodowej ICZMP w Lodzi w latach 1991-2000. Ginekologia Polska, 74, 1049-1054.

  • Bielańska-Osuchowska, Z. (2006). In vitro — zagrozenia. Tygodnik Powszechny, 36.

  • Biesaga, T. (2006). Europejska Konwencja Bioetyczna. Medycyna Praktyczna, 11, 24-28.

  • Bomba, D. A., Wielgoś, M. (1999). Wady wrodzone plodu w ciαzy powiklanej cukrzycα. Nowa Medycyna, 7, 7-8.

  • Bonduelle, M., Wennerholm, U.-B., Loft, A., Tarlatzis, B. C., Peters, C., Henriet, S., Mau, C., Victorin-Cederquist, A., Van Steirteghem, A., Balaska, A., Emberson, J. R. & Sutcliffe, A. G. (2005). A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Human Reproduction, 20, 413-419.

  • Boulet, S. L., Schieve, L. A., Nannini, A., Ferre, C., Devine, O., Cohen, B., Zhang, Z., Wright V. & Macaluso, M. (2008). Perinatal outcomes of twin births conceived using assisted reproduction technology: a population — based stuy, Human Reproduction, 23, 1941-1948. [CrossRef]

  • Bowdin, S., Brueton, L., Allen, C., Harrison, R., Kirby, G., Maher, E. R., Afnan, M., Kirkman-Brown, J., Barrat, C. & Reardon, W. (2007). A survey of assisted reproductive technology births and imprinting disorders. Human Reproduction, 22, 3237-3240. [CrossRef]

  • Budzyńska, J., Dudziak, U. (2003). Zaplodnienie «in vitro» w ocenie nauczycieli. Czestochowa: EDUCATOR.

  • Cebrat, S. (2008). Skrupuly biologa. Tygodnik Powszechny, 2.

  • Chang, A. S., Moley, K. H., Wangler, M., Feinberg, A. P. & DeBaun, M. R. (2005). Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertility and Sterility, 83, 349-354. [CrossRef]

  • Colpin, H. and Bossaert, G. (2008). Adolescents conceived by IVF: parental and psychosocial adjustment. Human Reproduction 23, 2724-2730. [CrossRef]

  • Cox, G. F., Burger, J., Lip, V., Mau, U. A., Sperling, K, Wu, B. L. & Horsthemke, B. (2002). Intacytoplasmic sperm injection may increase the risk of imprinting defects. American Journal of Human Genetics, 71, 162-164. [CrossRef]

  • De Sutter, P., Veldeman, L., Kok, P., Szymczak, N., Van der Elst & Dhont, M. (2005). Comparison of outcome of pregnancy after intra — uterine insemination (IUI) and IVF. Human Reproduction, 20, 1642-1646. [CrossRef]

  • DeBaun, M. R., Niemitz, E. L. & Feinberg, A. P. (2003). Association of In Vitro Fertilization with Beckwith-Wiedemann Syndrome and Epigenetic Alterations of LIT1 and H19. The American Journal of Human Genetics, 72, 156-160.

  • Dhont, M., De Sutter, P., Ruyssinck, G., Martens, G., Bekaert, A. (1999). Perinatal outcome of pregnancies after assisted reproduction: a case-control study. American Journal of Obstetrics and Gynecology, 181,688-695.

  • Doornbos, M., Maas, S. M., McDonnell, J., Vermeiden, J. P. W. & Hannekam, R. C. M. (2007). Infertility, assisted reproduction technologies and imprintning disturbances: a Dutch study. Human Reproduction, 22, 2476-2480. [CrossRef]

  • Draper, E. S., Kurinczuk, J. J., Abrams, K. R. & Clarke, M. (1999). Assessment of separate contributions to perinatal mortality of infrtility history and treatment: a case-control analysis. Lancet, 353,1746-1749.

  • Duszewska, A. M., Reklewski, Z. (2007). Uzyskiwanie zarodków zwierzαt gospodarskich in vitro. Medycyna Weterynaryjna, 63, 1522-1525.

  • Ericson, A., Kallen, B. (2001). Congenital malformations in infants born after IVF: A population-based study. Human Reproduction, 16, 504-509. [CrossRef]

  • ESHRE Capri Workshop Group (2005). Fertility and ageing. Human Reproduction Update, 11, 261-276. [CrossRef]

  • ESHRE Capri Workshop Group (2007). Intracytoplasmic sperm injection (ICSI) in 2006: Evidence and evolution. Human Reproduction Update, 13, 515-526.

  • FIVNAT (1995). Pregnancies and births resulting from in vitro fertilization: French National Registry, analysis of data 1986 to 1990. Fertility and Sterility, 64, 746-756.

  • Gicquel, C., Gaston, V., Mandelbaum, J, Le Bouc, Y. (2003). In Vitro Fertilization May Increase the Risk of Beckwith-Wiedemann Syndrome Related to the Abnormal Imprinting of the KCNQIOT Gene. American Journal of Human Genetics, 72, 1338-1341. [CrossRef] [PubMed]

  • Govaerts, I., Devreker, F., Koenig, I., Place, I. & Van den Bergh, M. (1998). Comparison of pregnancy outcome after intracytoplasmic sperm injection and in-vitro fertilization. Human Reproduction., 13, 1514-1518. [CrossRef]

  • Hansen, M., Kurinczuk, J. J., Bower, C. & Webb, S. (2002). The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertalization. New England Journal of Medicine, 346, 725-730.

  • Hansen, M., Bower, C., Milne, E., de Klerk, N. & Kurinczuk, J. J. (2005). Assisted reproductive technologies and the risk of birth defects — a systematic review. Human Reproduction, 20, 328-338.

  • Hvidjorn, D., Schieve, L., Schendel, D., Jacobsson, B., Svaerke, C. & Thorsen. P. (2009). Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception: A Systematic Review and Meta-analysis. Archives of Pediatrics & Adolescent Medicine. 163, 72-83. [CrossRef]

  • Hollier, L. M., Leveno, K. J., Kelly, M. A., MCIntrie, D. D., Cuningham, F. G. (2000). Maternal age and malformations in singleton births. Obstetric Gynecology, 96, 701-706. [CrossRef]

  • Katalinic, A., Rösch, C., Ludwig, M. (2004). Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertility and Sterility, 81, 1604-1616. [PubMed] [CrossRef]

  • Klemetti, R., Sevon, T., Gissler, M., Hamminki, E. (2006). Health of Children Born as a Result of In Vitro Fertilization. Pediatrics, 118, 1819-1827. [CrossRef] [PubMed]

  • Knoester, M., Helmerhorst, F. M., van der Westerlaken L. A. J., Walther, F. J. & Veen, S. (2007a). Matched follow-up study of 5-8-year-old ICSI singletons: child behaviour, parenting and child (health-related) quality of life. Human Reproduction, 22, 3098-3107. [CrossRef]

  • Knoester, M., Vandenbroucke, J. P., Helmerhorst, F. M., Van der Westerlaken, L. A., Walther, F. J., Veen, S. (2007b). Matched follow-up study of 5-8 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons. Human Reproduction, 22, 1638-1646.

  • Klip, H., Burger, C. W., de Kraker, J. and van Leeuwen, F. E. (2001). Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Human Reproduction, 16, 2451-2458.

  • Klonoff-Cohen, H. S., Natarajan, L. (2004). The effect of advancing paternal age on pregnancyrates and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer. American Journal of Obstetrics and Gynecology, 191, 507-514.

  • Kuchmister, K. (2009). Percepcja spoleczna problemu nieplodności w relacjach partnerskich. Praca magisterska niepublikowana. [Unpublished master thesis] Wroclaw: SWPS.

  • Kurinczuk, J. J. (2003). Safety issues in assisted reproduction technology — From theory to reality — just what are the data telling us about ICSI offspring health and future fertility and should we be concerned? Human Reproduction, 18, 925-931. [CrossRef]

  • Lambert, R. D. (2003). Safety issues in assisted reproductive technology: Aetiology of health problems in singleton ART babies. Human Reproduction, 18, 1987-1991. [CrossRef]

  • Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebauers, I. & Ponjaert-Kristoffersen, I. (2006). Cognitive and motor development of 8-year-old children after ICSI compered to spontaneously conceived children. Human Reproduction, 21, 2922-2929. [CrossRef]

  • Lidegaard, O., Pinborg, A., Andersen, A. N. (2005). Imprinting diseases and IVF. Danish National IVF Cohort Study. Human Reproduction, 20, 950-954.

  • Lie, R. T., Lyngstadaas, A., Orstavik, K. H., Bakketeig, L. S., Jacobsen, G. & Tanbo, T. (2005). birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a metaanalysis. International Journal of Epidemiology, 34, 696-701.

  • Lucifero, D., Chaillet, J. R. & Trasler, J. M. (2004). Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology. Human Reproduction Update, 10, 3-18. [CrossRef] [PubMed]

  • Ludwig, M., Katalinic, A., Gros, S., Sutclife, A., Varon, R., Horsthemke, B. (2005). Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. Journal of Medical Genetics, 42, 289-291. [PubMed] [CrossRef]

  • Maher, E. R., Afnan, M. & Barrat, C. L. (2003). Epigenetic risks related to assisted reproductive technologies: Epigenetics, imprinting, ART and icebergs? Human Reproduction, 18, 2508-2511. [CrossRef]

  • Manning, M., Lissens, W., Bonduelle, M., Camus, M., De Rijcke, M., Liebaers, I. & Van Steirteghem, A. (2000). Study of DNA-methylation patterns at chromosome 15q11-q13 in children born after ICSI reveals no imprinting defects. Molecular Human Reproduction, 6, 1049-1053. [CrossRef]

  • Nekkerbroeck, J., Bonduelle, M., Desmyttere, S., Van den Broeck, W. & Ponjaert-Kristoffersen, I. (2008a). Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening. Human Reproduction, 23, 1560-1566. [CrossRef]

  • Nekkerbroeck, J., Bonduelle, M., Desmyttere, S., Van den Broeck, W. & Ponjaert-Kristoffersen, I. (2008b). Socio-emotional and language development of 2-year-old children born after PGd/PGS, and parental well-being. Human Reproduction, 23, 1849-1857. [CrossRef]

  • Orstavik, K. H., Eiklid, K., van der Hagen, C. B., Spetalen, S., Kierulf, K., Skjeldal, O. & Buiting, K. (2003). Another case of imprinting defect in a girl with angelman syndrome who was conceived by introcytopasmic semen injection. American Journal of Human Genetics, 72, 218-219. [CrossRef]

  • Papaligoura, Z., Panopoulou-Maratou, O., Solman, M., Arvaniti, K., Sarafidou, J. (2004). Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Human Reproduction, 19, 1488-1493. [CrossRef]

  • Pelwecka, A. (2007). Postawy religijne w konfrontacji z leczeniem nieplodności technikami rozrodu wspomaganego. Praca magisterska niepublikowana. [Unpublished master thesis] Wroclaw: SWPS.

  • Pinborg, A., Loft, A., Schmidt, L. & Andersen, A. N. (2003). Morbidity in a Danish National cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Human Reproduction, 18, 1234-1243.

  • Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., Nekkebroeck, J., Loft, A., Wennerholm, U.-B., Tarlatzis, B. C., Peters, B., Hagberg, B. S., Berner, A. & Sutcliffe, A. G. (2005). International Collaborative Study of Intracytoplasmatic Sperm Injection-Conceived, In Vitro Fertilization-Concieved, and Naturally Conceived 5-Year Old Child Outcomes: Cognitive and Motor Assessments. Pediatrics, 115, 283-289. [CrossRef]

  • Reefhuis, J., Honein, M. A. (2004). Maternal age and non-chromosomal birth defects, Atlanta — 1968-2000: Teenager or thirty-smomething, who is at risk? Clinical and Molecular Teratology, 70, 572-579.

  • Reefhuis, J., Honein, M. A., Schieve, L. A., Correa, A., Hobbs, C. A. & Rasmussen, S. A. (2009). Assisted reproductive technologu and major structural birth defects in the United States. Human Reproduction, 24,360-366. [CrossRef]

  • Sadowska, L. (2008). Bezduszna technika i biznes. Nasz Dziennik, 19.

  • Schieve, L. A., Meikle, S. F., Ferre, C., Peterson, H. B., Jeng, G. & Wilcox, L. S. (2002). Low and very low birth weight in infants conceived with use of assisted reproductive technology. New England Journal of Medicine, 346, 731-737.

  • Sheffer-Mimouni, G., Mashiach, S., Dor, J., Lavran, D. & Seidman, D. S. (2002). Factors influencing the obstetric and perinatal outcome after oocyte donation. Human Reproduction, 17, 2636-2640. [CrossRef]

  • Soderstrom-Anttila, V., Tiitinen, A, Foudila, T. & Hovatta, O. (1998). Obstetric and perinatal outcome after oocyte donation: comparison with in-vitro pregnancies. Human Reproduction. 13, 483-490. [CrossRef]

  • Sun, Y., Vestergaard, M., Christensen, J., Zhu, J. L., Bech, B. H. & Olsen, J. (2007). Epilepsy and febrile seizures in children of treated and untreated subfertile couples. Human Reproduction, 22, 215-220.

  • Sutcliffe, A. G., D'Souza, S. W., Cadman, J., Richards, B., McKinlay, I. A. & Lieberman, B. A. (1995). Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Human Reproduction., 10, 3332-3337.

  • Śliwa, L. (2008). Wplyw leczenia nieplodności technikα rozrodu wspomaganego na zdrowotność populacji ludzkiej. Nowa Medycyna, 1, 11-14.

  • Wagenaar, K., van Weissenbruch, M. M., Knol, D. L., Cohen-Kettenis, P. T., Delemarre-van de Waal, H. A. & Huisman, J. (2009). Information processing, attention and visual-motor function of adolescents born after in vitro fertilization compared with spontaneous conception. Human Reproduction, 24, 913-921.

  • Westergaard, H. B., Tranberg Johansen, A. M., Erb, K. & Andersen, A. N. (1999). Danish national in-vitro fertilization registry 1994 and 1995: a controlled study of births, malformations and cytogenetic findings. Human Reproduction, 14, 1896-1902.

  • Zhu, J. L., Basso, O., Obel, C., Bille, C. & Olsen, J. (2006). Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ doi: 10.1136/bmj.38919.495718.AE.

  • Zhu, J. L., Basso, O., Bech, B. H., Nohr, E. A., Shrestha, A. & Olsen, J. (2009). Parental infertlity and sexual maturation in children. Human Reproduction, 24, 445-450. [CrossRef]

Comments (0)

Please log in or register to comment.