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Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Her2 Expression and Response of Breast Cancer to Adjuvant Chemotherapy

Alinta Hegmane1 / Uldis Vikmanis1

Latvian Oncology Centre, Rīga Eastern University Hospital, Hipokrāta iela 4, Rīga, LV-1079, LATVIA1

Faculty of Medicine, University of Latvia, Šarlotes iela 1a, Rīga, LATVIA2

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Citation Information: Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.. Volume 62, Issue 3, Pages 129–132, ISSN (Print) 1407-009X, DOI: 10.2478/v10046-008-0023-0, November 2008

Publication History

Published Online:
2008-11-29

Her2 Expression and Response of Breast Cancer to Adjuvant Chemotherapy

Expression of the human epidermal growth factor receptor type 2 (HER2) in breast cancer patients may predict response to anthracycline or non anthracycline-based adjuvant chemotherapy. A total of 192 breast cancer patients diagnosed at the Latvian Oncology Centre from January 2002 to August 2005 were included in the study. Patients had histopathologically confirmed breast cancer, had undergone radical surgery and received at least four courses of adjuvant chemotherapy. HER2 expression was evaluated by immunohystochemical analysis. Median follow-up time was 32.1 months. In HER2 negative patients, the mean time to recurrence was 26.9 months (SD 1.465; 95%CI 23.9-29.4) for patients received antracycline-based chemotherapy and 33.2 months (SD 1.308; 95%CI 30.6-35.8) in the CMF chemotherapy group (P < 0.05). These HER2 negative patients could be treated with a less toxic regimen of CMF. In HER2 overexpressed patients receiving anthracycline based chemotherapy, mean time to recurrence was 30 months (SD 2.170; 95%CI 25.7-34.4) compared with 29.2 months (SD 1.965; 95%CI 25.4-33.1) in patients who received CMF, but the difference was not significant (P > 0.05).

Her2 Ekspresijas Loma Krūts Vēža Adjuvantās Ķīmijterapijas Izvēlē

Cilvēka epidermālā augšanas faktora receptora 2 (HER2) ekspresijai var būt nozīme, lai izvēlētos adjuvantu ķīmijterapiju ar vai bez antraciklīniem pacientēm ar krūts vēzi. Pētījumā tika iekļautas 192 pacientes, kurām Latvijas Onkologijas centrā laika posmā no 2002. gada janvāra līdz 2005. gada augustam tika diagnosticēts krūts vēzis. Galvenie iekļaušanas kritēriji bija morfologiski verificēta krūts vēža diagnoze un imūnhistoķīmiski noteikts HER2. Pacientēm bija izdarīta radikāla operācija un vismaz četri adjuvantas ķīmijterapijas kursi. Vidējais novērošanas laiks bija 32,1 mēnesis. Pacientēm, kurām nebija novērota HER2 receptora pārmērīga ekspresija un kuras sañēma ķīmijterapiju ar antraciklīniem, vidējais laiks līdz recidīvam bija 26,9 mēneši (SD 1.465; 95%CI 23,9-29,4), CMF grupā 33,2 mēneši (SD 1,308; 95%CI 30,6-35,8), atšķirība ir būtiska (P < 0,05), šīm pacientēm var rekomendēt mazāk toksisku CMF ķīmijterapiju. Pacientēm ar HER2 receptora pārmērīgu ekspresiju, kuras sañēma ķīmijterapiju ar antraciklīniem, vidējais laiks līdz recidīvam bija 30 mēneši (SD 2.170; 95%CI 25,7-34,4) salīdzinājumā ar 29,2 mēnešiem (SD 1.965; 95%CI 25,4-33,1) CMF ķīmijterapijas grupā, atšķirība nav būtiska (P > 0,05).

Keywords: breast cancer; HER2; adjuvant chemotherapy

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