Reviews on Environmental Health
Editor-in-Chief: Carpenter, David O. / Sly, Peter
Editorial Board Member: Brugge, Doug / Diaz-Barriga, Fernando / Edwards, John W. / Field, R.William / Hales, Simon / Horowitz, Michal / Maibach, H.I. / Shaw, Susan / Stein, Renato / Tao, Shu / Tchounwou, Paul B.
SCImago Journal Rank (SJR) 2015: 0.776
Source Normalized Impact per Paper (SNIP) 2015: 0.676
Impact per Publication (IPP) 2015: 1.795
Genotoxicity of metal nanoparticles
1Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME, USA
2Maine Center for Toxicology and Environmental Health and Department of Applied Medical Sciences, University of Southern Maine, Portland, ME, USA
3Department of Chemical and Biological Engineering and the Institute for Molecular Biophysics, University of Maine, Orono, ME, USA
Citation Information: Reviews on Environmental Health. Volume 26, Issue 4, Pages 251–268, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: 10.1515/REVEH.2011.033, December 2011
Nanotechnology is currently used in industry, medicine, and military applications, as well as in more than 300 commercial products. Yet, the same properties that make these particles exciting for technology also make them daunting public health concerns because their toxicity is unknown and relatively unexplored. Increased attention is being placed on the study of metal particle genotoxicity; however, a lot of unknowns remain about their effects and the mechanisms. In this article, we highlight some metal and metal oxide nanoparticles of interest and discuss the current in vivo and in vitro studies of genotoxic effects. Many metal nanoparticles were found to cause chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. Inconsistencies are found in the literature, however, thus drawing conclusions is difficult due to a variety of factors. Therefore, the areas requiring further attention are highlighted and recommendations to improve our understanding of the genotoxic potential are addressed.
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