Jump to ContentJump to Main Navigation

Reviews on Environmental Health

Editor-in-Chief: Carpenter, David O. / Sly, Peter

Editorial Board Member: Brugge, Doug / Diaz-Barriga, Fernando / Edwards, John W. / Field, R.William / Hales, Simon / Horowitz, Michal / Maibach, H.I. / Shaw, Susan / Stein, Renato / Tao, Shu / Tchounwou, Paul B.

4 Issues per year

SCImago Journal Rank (SJR) 2014: 0.702
Source Normalized Impact per Paper (SNIP) 2014: 0.619
Impact per Publication (IPP) 2014: 1.900



Genotoxicity of metal nanoparticles

Hong Xie1, 2 / Michael M. Mason2, 3 / 1, 2

1Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME, USA

2Maine Center for Toxicology and Environmental Health and Department of Applied Medical Sciences, University of Southern Maine, Portland, ME, USA

3Department of Chemical and Biological Engineering and the Institute for Molecular Biophysics, University of Maine, Orono, ME, USA

Corresponding author: Dr. John Pierce Wise Sr., University of Southern Maine, P.O. Box 4000, 96 Falmouth Street, Portland, ME 04104, USA Phone: +1-207-228-8050, Fax: +1-207-228-8057

Citation Information: Reviews on Environmental Health. Volume 26, Issue 4, Pages 251–268, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: 10.1515/REVEH.2011.033, December 2011

Publication History



Nanotechnology is currently used in industry, medicine, and military applications, as well as in more than 300 commercial products. Yet, the same properties that make these particles exciting for technology also make them daunting public health concerns because their toxicity is unknown and relatively unexplored. Increased attention is being placed on the study of metal particle genotoxicity; however, a lot of unknowns remain about their effects and the mechanisms. In this article, we highlight some metal and metal oxide nanoparticles of interest and discuss the current in vivo and in vitro studies of genotoxic effects. Many metal nanoparticles were found to cause chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. Inconsistencies are found in the literature, however, thus drawing conclusions is difficult due to a variety of factors. Therefore, the areas requiring further attention are highlighted and recommendations to improve our understanding of the genotoxic potential are addressed.

Keywords: chromosome aberration; DNA damage; metal nanoparticle; mutation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jie Kai Tee, Choon Nam Ong, Boon Huat Bay, Han Kiat Ho, and David Tai Leong
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015, Page n/a
Nazanin Golbamaki, Bakhtiyor Rasulev, Antonio Cassano, Richard L. Marchese Robinson, Emilio Benfenati, Jerzy Leszczynski, and Mark T. D. Cronin
Nanoscale, 2015, Volume 7, Number 6, Page 2154
Vaiyapuri S. Periasamy, Jegan Athinarayanan, Mohammad Alhazmi, Khalid A Alatiah, and Ali A. Alshatwi
Environmental Toxicology, 2014, Page n/a
Francine C. Cadoná, Maria F. Manica-Cattani, Alencar K. Machado, Raul M. Oliveira, Eliza Ribas da Silveira Flôres, Charles Assmann, Thais D. Algarve, and Ivana B. M. da Cruz
Anal. Methods, 2014, Volume 6, Number 21, Page 8559
Amruta Manke, Liying Wang, and Yon Rojanasakul
BioMed Research International, 2013, Volume 2013, Page 1
L. Fan, Y. Niu, S. Zhang, L. Shi, H. Guo, Y. Liu, and R. Zhang
Mutagenesis, 2013, Volume 28, Number 5, Page 515
Zuzana Magdolenova, Andrew Collins, Ashutosh Kumar, Alok Dhawan, Vicki Stone, and Maria Dusinska
Nanotoxicology, 2014, Volume 8, Number 3, Page 233
Jose L. Luque-Garcia, Raquel Sanchez-Díaz, Isabel Lopez-Heras, Carmen Camara, and Pilar Martin
TrAC Trends in Analytical Chemistry, 2013, Volume 43, Page 254
Magdiel Inggrid Setyawati, Wanru Fang, Sing Ling Chia, and David Tai Leong
Asia-Pacific Journal of Chemical Engineering, 2013, Volume 8, Number 2, Page 205

Comments (0)

Please log in or register to comment.