Reviews on Environmental Health
Editor-in-Chief: Carpenter, David O. / Sly, Peter
Editorial Board Member: Brugge, Doug / Diaz-Barriga, Fernando / Edwards, John W. / Field, R.William / Hales, Simon / Horowitz, Michal / Maibach, H.I. / Shaw, Susan / Stein, Renato / Tao, Shu / Tchounwou, Paul B.
4 Issues per year
SCImago Journal Rank (SJR): 0.566
Source Normalized Impact per Paper (SNIP): 0.545
Volume 30 (2015)
Volume 29 (2014)
Volume 28 (2013)
Volume 27 (2012)
Volume 26 (2011)
Volume 25 (2010)
Volume 24 (2009)
Volume 23 (2008)
Volume 22 (2007)
Volume 21 (2006)
Volume 20 (2005)
Volume 18 (2003)
Volume 17 (2002)
Volume 16 (2001)
Volume 15 (2000)
Volume 14 (1999)
Volume 12 (1997)
Volume 11 (1996)
Volume 10 (1994)
Volume 9 (1991)
Volume 6 (1986)
Most Downloaded Articles
- Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations by Webb, Ellen/ Bushkin-Bedient, Sheila/ Cheng, Amanda/ Kassotis, Christopher D./ Balise, Victoria and Nagel, Susan C.
- Understanding exposure from natural gas drilling puts current air standards to the test by Brown, David/ Weinberger, Beth/ Lewis, Celia and Bonaparte, Heather
- Human exposures to bisphenol A: mismatches between data and assumptions by Vandenberg, Laura N./ Hunt, Patricia A./ Myers, John Peterson and vom Saal, Frederick S.
- Human disease resulting from exposure to electromagnetic fields1) by Carpenter, David O.
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation
1Environmental Toxicology Research Laboratory, NIH-RCMI Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA
Citation Information: . Volume 27, Issue 2-3, Pages 103–116, ISSN (Online) 2191-0308, ISSN (Print) 0048-7554, DOI: 10.1515/reveh-2012-0026, October 2012
- Published Online:
Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans.
Keywords: aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors; biologic rhythmicity; carcinogenicity; climate change; seasonal-circadian rhythms; skin disorders