Jump to ContentJump to Main Navigation

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

6 Issues per year


IMPACT FACTOR increased in 2014: 3.330
5-year IMPACT FACTOR: 3.358
Rank 97 out of 252 in category Neurosciences in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.488
Source Normalized Impact per Paper (SNIP) 2014: 0.885
Impact per Publication (IPP) 2014: 3.675

VolumeIssuePage

Issues

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

1 / Jorge Valero1

1Institut de Neurociències, Departament Bioquímica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain

Corresponding author

Citation Information: Reviews in the Neurosciences. Volume 22, Issue 2, Pages 153–169, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: 10.1515/rns.2011.018, April 2011

Publication History

Published Online:
2011-04-12

Abstract

Gene expression changes in the brain affect cognition during normal and pathological aging. Progress in understanding the cellular processes regulating gene expression networks in cognition is relevant to develop therapeutic interventions for age-related cognitive disorders. Synaptic efficacy mediating memory storage requires the activation of specific gene expression programs regulated, among others, by the transcription factor cAMP-response element binding protein (CREB). CREB signaling is essential for long-lasting changes in synaptic plasticity that mediates the conversion of short-term memory to long-term memory. CREB signaling has been recently involved in several brain pathological conditions including cognitive and neurodegenerative disorders. The β-amyloid (Aβ) peptide, which plays a crucial role in the pathogenesis of Alzheimer’s disease, alters hippocampal-dependent synaptic plasticity and memory and mediates synapse loss through the CREB signaling pathway. The fact that altered CREB signaling has been implicated in other cognitive disorders including Huntington’s disease and Rubinstein-Taybi and Coffin-Lowry syndromes suggests a crucial role of CREB signaling in cognitive dysfunction. In this review paper, we summarize recent findings indicating a role of CREB and its coactivators CREB binding protein and CREB-regulated transcription coactivator in cognition during normal and pathological aging. We also discuss the development of novel therapeutic strategies based on CREB targeting to ameliorate cognitive decline in aging and cognitive disorders.

Keywords: aging; Alzheimer’s disease; amyloid; cAMP-response element binding protein (CREB); CREB-regulated transcription coactivator (CRTC); dementia; gene expression; Huntington’s disease; neurodegeneration

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Carlos A. Saura, Arnaldo Parra-Damas, and Lilian Enriquez-Barreto
Frontiers in Cellular Neuroscience, 2015, Volume 9
[2]
Yohan D’Souza, Ahmed Elharram, Raquel Soon-Shiong, R David Andrew, and Brian M Bennett
Molecular Brain, 2015, Volume 8, Number 1
[4]
Eva Bollen and Jos Prickaerts
IUBMB Life, 2012, Volume 64, Number 12, Page 965
[5]
Chinmay Y. Majmudar, Jonas W. Højfeldt, Carl J. Arevang, William C. Pomerantz, Jessica K. Gagnon, Pamela J. Schultz, Laura C. Cesa, Conor H. Doss, Steven P. Rowe, Victor Vásquez, Giselle Tamayo-Castillo, Tomasz Cierpicki, Charles L. Brooks, David H. Sherman, and Anna K. Mapp
Angewandte Chemie, 2012, Volume 124, Number 45, Page 11420
[6]
Zhihui Qin, Jia Luo, Lawren VandeVrede, Ehsan Tavassoli, Mauro Fa’, Andrew F. Teich, Ottavio Arancio, and Gregory R. J. Thatcher
Journal of Medicinal Chemistry, 2012, Volume 55, Number 15, Page 6784
[7]
De-shan Liu, Xiao-dong Pan, Jing Zhang, Hui Shen, Nicole C Collins, Arron M Cole, Kevin P Koster, Manel Ben Aissa, Xiao-man Dai, Meng Zhou, Leon M Tai, Yuan-gui Zhu, Mary Jo LaDu, and Xiao-chun Chen
Molecular Neurodegeneration, 2015, Volume 10, Number 1
[8]
Cota Navin Gupta, Jiayu Chen, Jingyu Liu, Eswar Damaraju, Carrie Wright, Nora I. Perrone-Bizzozero, Godfrey Pearlson, Li Luo, Andrew M. Michael, Jessica A. Turner, and Vince D. Calhoun
Frontiers in Human Neuroscience, 2015, Volume 9
[9]
Zhe Shi, Lingling Chen, Sidi Li, Shanguang Chen, Xiuping Sun, Lihua Sun, Yinghui Li, Jianguo Zeng, Yiran He, and Xinmin Liu
Psychopharmacology, 2013, Volume 230, Number 2, Page 245
[11]
Alessio Menga, Vito Iacobazzi, Vittoria Infantino, Maria Laura Avantaggiati, and Ferdinando Palmieri
The International Journal of Biochemistry & Cell Biology, 2015, Volume 60, Page 157
[12]
Qin Zhihui
Future Medicinal Chemistry, 2013, Volume 5, Number 12, Page 1451
[13]
Simon Chiu, Nigel Gericke, Michel Farina-Woodbury, Vladimir Badmaev, Hana Raheb, Kristen Terpstra, Joalex Antongiorgi, Yves Bureau, Zack Cernovsky, Jirui Hou, Veronica Sanchez, Marissa Williams, John Copen, Mariwan Husni, and Liz Goble
Evidence-Based Complementary and Alternative Medicine, 2014, Volume 2014, Page 1
[14]
Mi-Ran Choi, Min Young Lee, Ji Eun Hong, Jeong Eun Kim, Jae-Yong Lee, Tae Hwan Kim, Jang Woo Chun, Hyun Kyung Shin, and Eun Ji Kim
Journal of Medicinal Food, 2014, Volume 17, Number 10, Page 1049
[15]
Jin Bae Weon, Bo-Ra Yun, Jiwoo Lee, Min Rye Eom, Hyun-Jeong Ko, Hyeon Yong Lee, Dong-Sik Park, Hee-Chul Chung, Jae Youn Chung, and Choong Je Ma
Evidence-Based Complementary and Alternative Medicine, 2014, Volume 2014, Page 1
[16]
Biao Wang, Jiuhan Zhao, Meng Yu, Xin Meng, Xin Cui, Yan Zhao, Yuyan Zhu, Wei Xing, and Yifu Guan
Neurotoxicity Research, 2014, Volume 26, Number 1, Page 52
[17]
Matthew P. Parsons and Lynn A. Raymond
Neuron, 2014, Volume 82, Number 2, Page 279
[18]
Yoelvis García-Mesa, Helios Pareja-Galeano, Vicent Bonet-Costa, Susana Revilla, M. Carmen Gómez-Cabrera, Juan Gambini, Lydia Giménez-Llort, Rosa Cristòfol, José Viña, and Coral Sanfeliu
Psychoneuroendocrinology, 2014, Volume 45, Page 154
[19]
Jose Vicente Sanchez-Mut, Ester Aso, Holger Heyn, Tadashi Matsuda, Christoph Bock, Isidre Ferrer, and Manel Esteller
Hippocampus, 2014, Volume 24, Number 4, Page 363
[20]
Wei-Lun Hsu, Yun-Li Ma, Ding-You Hsieh, Yen-Chen Liu, and Eminy HY Lee
Neuropsychopharmacology, 2014, Volume 39, Number 3, Page 746
[21]
Jan Pláteník, Zdeněk Fišar, Richard Buchal, Roman Jirák, Eva Kitzlerová, Martina Zvěřová, and Jiří Raboch
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014, Volume 50, Page 83
[22]
J. V. Sanchez-Mut, E. Aso, N. Panayotis, I. Lott, M. Dierssen, A. Rabano, R. G. Urdinguio, A. F. Fernandez, A. Astudillo, J. I. Martin-Subero, B. Balint, M. F. Fraga, A. Gomez, C. Gurnot, J.-C. Roux, J. Avila, T. K. Hensch, I. Ferrer, and M. Esteller
Brain, 2013, Volume 136, Number 10, Page 3018
[23]
N. Jin, W. Qian, X. Yin, L. Zhang, K. Iqbal, I. Grundke-Iqbal, C.-X. Gong, and F. Liu
Nucleic Acids Research, 2013, Volume 41, Number 5, Page 3240
[24]
A. Bilkei-Gorzo
Philosophical Transactions of the Royal Society B: Biological Sciences, 2012, Volume 367, Number 1607, Page 3326
[25]
Ki Yong Lee, Eun Ju Jeong, Jungmoo Huh, Namki Cho, Tae Bum Kim, Byung Ju Jeon, Seung Hyun Kim, Hong Pyo Kim, and Sang Hyun Sung
Phytomedicine, 2012, Volume 19, Number 14, Page 1315
[26]
Hui Wang, Andrea Megill, Kaiwen He, Alfredo Kirkwood, and Hey-Kyoung Lee
Neural Plasticity, 2012, Volume 2012, Page 1
[27]
Carlos A. Saura
Neurodegenerative Diseases, 2012, Volume 10, Number 1-4, Page 250
[28]
Antero Salminen and Kai Kaarniranta
Ageing Research Reviews, 2012, Volume 11, Number 2, Page 230
[30]
Angel Barco and Hélène Marie
Molecular Neurobiology, 2011, Volume 44, Number 3, Page 330
[31]
Sa Rang Oh, Eun-Mi Ahn, and Ji Wook Jung
Oriental Pharmacy and Experimental Medicine, 2011, Volume 11, Number 3, Page 199
[32]
Susanne Muller, Panagis Filippakopoulos, and Stefan Knapp
Expert Reviews in Molecular Medicine, 2011, Volume 13
[33]
M. Muller, C. Cardenas, L. Mei, K.-H. Cheung, and J. K. Foskett
Proceedings of the National Academy of Sciences, 2011, Volume 108, Number 32, Page 13293

Comments (0)

Please log in or register to comment.