Jump to ContentJump to Main Navigation

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

6 Issues per year


IMPACT FACTOR increased in 2014: 3.330
5-year IMPACT FACTOR: 3.358
Rank 97 out of 252 in category Neurosciences in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.488
Source Normalized Impact per Paper (SNIP) 2014: 0.885
Impact per Publication (IPP) 2014: 3.675

VolumeIssuePage

Issues

Inducible pluripotent stem cells for the treatment of ischemic stroke: current status and problems

Yu Zhu1 / Shu Wan1 / 1

1Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China

Corresponding author: Ren-ya Zhan, Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China

Citation Information: . Volume 23, Issue 4, Pages 393–402, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: 10.1515/revneuro-2012-0042, June 2012

Publication History

Received:
2012-04-02
Accepted:
2012-05-04
Published Online:
2012-06-24

Abstract

Despite dramatic advancements in medical and surgical care, effective clinical therapies for ischemic stroke are limited. Stem-cell transplantation has emerged as a potential therapeutic approach for cell replacement in ischemic brain injuries. Inducible pluripotent stem cells (iPSCs) have become an alternative cell source for transplantation. They possess efficient capacities for neural differentiation without ethical and immune-rejection concerns. Substantial function of iPSCs in pre-clinical models of ischemic brain injury has been observed. However, several problems remain regarding the treatment of ischemic stroke with iPSCs: tumorigenicity, poor iPSC derivation methods, and undefined delivery variables. With the development of iPSC research, safer and more effective strategies will be achieved for highly effective and tumor-free cell treatment of ischemic stroke.

Keywords: inducible pluripotent stem cell; ischemic stroke; neural differentiation; stem cell transplantation; tumorigenicity

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Janna C. Nawroth and Kevin Kit Parker
Biotechnology Advances, 2013, Volume 31, Number 5, Page 632

Comments (0)

Please log in or register to comment.