Jump to ContentJump to Main Navigation

Reviews in the Neurosciences

Editor-in-Chief: Huston, Joseph P.

Editorial Board Member: Topic, Bianca / Adeli, Hojjat / Buzsaki, Gyorgy / Crawley, Jacqueline / Crow, Tim / Eichenbaum, Howard / Gold, Paul / Holsboer, Florian / Korth, Carsten / Lubec, Gert / McEwen, Bruce / Pan, Weihong / Pletnikov, Mikhail / Robbins, Trevor / Schnitzler, Alfons / Stevens, Charles / Steward, Oswald / Trojanowski, John

6 Issues per year


IMPACT FACTOR increased in 2014: 3.330
5-year IMPACT FACTOR: 3.358
Rank 97 out of 252 in category Neurosciences in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.488
Source Normalized Impact per Paper (SNIP) 2014: 0.885
Impact per Publication (IPP) 2014: 3.675

VolumeIssuePage

Issues

Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative

1Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico

Corresponding author: Alfredo Meneses, Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico, e-mail:

Citation Information: Reviews in the Neurosciences. Volume 25, Issue 3, Pages 325–356, ISSN (Online) 2191-0200, ISSN (Print) 0334-1763, DOI: 10.1515/revneuro-2014-0001, April 2014

Publication History

Received:
2013-12-03
Accepted:
2014-01-27
Published Online:
2014-04-03

Abstract

Agonists and antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) or receptor7 (5-HT7) might improve memory and/or reverse amnesia, although the mechanisms involved are poorly understood. Hence, the current work summarizes recent reviews and findings involving these receptors. Evidence indicates that diverse 5-HT6 receptor antagonists produce promnesic and/or antiamnesic effect in conditions, such as memory formation, age-related cognitive impairments and memory deficit in preclinical studies, as well as in diseases such as schizophrenia, Parkinson’s, and Alzheimer’s disease (AD). Memory, aging, and AD modify 5-HT6 receptors and signaling cascades; likewise, the modulation of 5-HT6 drugs on memory seems to be accompanied with neural changes. Moreover, 5-HT7 receptors are localized in brain areas mediating memory, including the cortex, hippocampus (e.g., Zola-Morgan and Squire, 1993) and raphe nuclei; however, the role of these receptors on memory has yet to be fully explored. Hence, findings and reviews are summarized in this work. Evidence suggests that both 5-HT7 receptor agonists and antagonists might have promnesic and anti-amnesic effects. These effects seem to be dependent on the basal level of performance, i.e., normal or impaired. Available evidence suggests that a potential utility of 5-HT6 and 5-HT7 receptor in mild-to-moderate AD patients and other memory dysfunctions as therapeutic targets.

Keywords: drugs; memory; 5-HT receptors

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Agata Antonina Rita Impellizzeri, Matteo Pappalardo, Livia Basile, Ornella Manfra, Kjetil Wessel Andressen, Kurt Allen Krobert, Angela Messina, Finn Olav Levy, and Salvatore Guccione
Frontiers in Behavioral Neuroscience, 2015, Volume 9
[2]
Megan Elizabeth Rich and Heather Kingsley Caldwell
Frontiers in Endocrinology, 2015, Volume 6
[3]
Bianca De Filippis, Valentina Chiodi, Walter Adriani, Enza Lacivita, Cinzia Mallozzi, Marcello Leopoldo, Maria Rosaria Domenici, Andrea Fuso, and Giovanni Laviola
Frontiers in Behavioral Neuroscience, 2015, Volume 9
[4]
Anthoula Tsolaki, Vasiliki Kosmidou, Leontios Hadjileontiadis, Ioannis (Yiannis) Kompatsiaris, and Magda Tsolaki
Brain Research, 2015, Volume 1603, Page 32

Comments (0)

Please log in or register to comment.