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Statistical Applications in Genetics and Molecular Biology

Editor-in-Chief: Stumpf, Michael P.H.

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Pre-validation and inference in microarrays

Robert J. Tibshirani1 / Brad Efron2

1Stanford University

2Stanford University

Citation Information: Statistical Applications in Genetics and Molecular Biology. Volume 1, Issue 1, ISSN (Online) 1544-6115, DOI: 10.2202/1544-6115.1000, August 2002

Publication History

Published Online:
2002-08-22

In microarray studies, an important problem is to compare a predictor of disease outcome derived from gene expression levels to standard clinical predictors. Comparing them on the same dataset that was used to derive the microarray predictor can lead to results strongly biased in favor of the microarray predictor. We propose a new technique called ``pre-validation'' for making a fairer comparison between the two sets of predictors. We study the method analytically and explore its application in a recent study on breast cancer.

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