In candidate gene association studies, usually several elementary hypotheses are tested simultaneously using one particular set of data. The data normally consist of partly correlated SNP information. Every SNP can be tested for association with the disease, e.g., using the Cochran-Armitage test for trend. To account for the multiplicity of the test situation, different types of multiple testing procedures have been proposed. The question arises whether procedures taking into account the discreteness of the situation show a benefit especially in case of correlated data. We empirically evaluate several different multiple testing procedures via simulation studies using simulated correlated SNP data. We analyze FDR and FWER controlling procedures, special procedures for discrete situations, and the minP-resampling-based procedure. Within the simulation study, we examine a broad range of different gene data scenarios. We show that the main difference in the varying performance of the procedures is due to sample size. In small sample size scenarios, the minP-resampling procedure though controlling the stricter FWER even had more power than the classical FDR controlling procedures. In contrast, FDR controlling procedures led to more rejections in higher sample size scenarios.

Editor-in-Chief: Stumpf, Michael P.H.
Editorial Board Member: Beaumont, Mark / Binder, Harald / Gupta, Mayetri / Hubbard, Alan E. / Husmeier, Dirk / Ji, Hongkai / Keles, Sunduz / Kerr, Kathleen / Lazzeroni, Laura / Lin, Shili / Ma, Ping / Marjoram, Paul / Mertens, Bart / Nerman, Olle / G. Petretto, Enrico / Plagnol, Vincent / Purdom, Elizabeth / Robin, Stéphane / Rzhetsky, Andrey / Sanguinetti, Guido / van der Laan, Mark J. / von Haeseler, Arndt / Weeks, Daniel E. / Wiuf, Carsten / Zhao, Hongyu
1 Issue per year
IMPACT FACTOR 2011: 1.517
5-year IMPACT FACTOR: 1.704
Rank 27 out of 116 in category Statistics & Probability in the 2011 Thomson Reuters Journal Citation Report/Science Edition
Issues
Volume 12 (2013)
Volume 11 (2012)
Volume 10 (2011)
Volume 9 (2010)
Volume 8 (2009)
Volume 7 (2008)
Volume 6 (2007)
Volume 5 (2006)
Volume 4 (2005)
Volume 3 (2004)
Volume 2 (2003)
Volume 1 (2002)
Most Downloaded Articles
- A General Framework for Weighted Gene Co-Expression Network Analysis by Zhang, Bin and Horvath, Steve
- Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments by Smyth, Gordon K
- Detecting Differential Expression in RNA-sequence Data Using Quasi-likelihood with Shrunken Dispersion Estimates by Lund, Steven P./ Nettleton, Dan/ McCarthy, Davis J. and Smyth, Gordon K.
- Adjusting for Spurious Gene-by-Environment Interaction Using Case-Parent Triads by Shin, Ji-Hyung/ Infante-Rivard, Claire/ Graham, Jinko and McNeney, Brad
- A Shrinkage Approach to Large-Scale Covariance Matrix Estimation and Implications for Functional Genomics by Schäfer, Juliane and Strimmer, Korbinian
Multiple Testing in Candidate Gene Situations: A Comparison of Classical, Discrete, and Resampling-Based Procedures
1University Medical Center of Johannes Gutenberg University Mainz
1Merck KGaA Germany
1University Medical Center of Johannes Gutenberg University Mainz
Citation Information: Statistical Applications in Genetics and Molecular Biology. Volume 10, Issue 1, Pages 1–21, ISSN (Online) 1544-6115, DOI: 10.2202/1544-6115.1729, November 2011
- Published Online:
- 2011-11-02
Keywords: resampling; minP; Cochran-Armitage trend test; SNP; Bonferroni; discrete test statistics; candidate gene


















Comments (0)