Most Downloaded Articles
- Joint Spatio-Temporal Modeling of Mycobacterium bovis Infections in Badgers and Cattle – Results from the Irish Four Area Project by Kelly, Gabrielle E.
- Estimating Trends in Incidence, Time-to-Diagnosis and Undiagnosed Prevalence using a CD4-based Bayesian Back-calculation by Birrell, Paul J./ Chadborn, Tim R./ Gill, O. Noel/ Delpech, Valerie C. and De Angelis, Daniela
- Using HIV Diagnostic Data to Estimate HIV Incidence: Method and Simulation by Yan, Ping/ Zhang, Fan and Wand, Handan
- Maximum a Posteriori Estimation in Dynamical Models of Primary HIV Infection by Drylewicz, Julia/ Commenges, Daniel and Thiebaut, Rodolphe
- Infectious Disease Modeling: Creating a Community to Respond to Biological Threats by Kaufman, James/ Edlund, Stefan and Douglas, Judith
Using HIV Diagnostic Data to Estimate HIV Incidence: Method and Simulation
1Public Health Agency of Canada
2Public Health Agency of Canada
3National Centre in HIV Epidemiology and Clinical Research
Citation Information: Statistical Communications in Infectious Diseases. Volume 3, Issue 1, ISSN (Online) 1948-4690, DOI: 10.2202/1948-4690.1011, October 2011
- Published Online:
We propose a new approach to estimate the number of new infections with the human immunodeficiency virus (HIV), by integrating the back-calculation method based on HIV diagnostic data with proportions of recent infections among newly diagnosed individuals. This is done by establishing an explicit link between the distribution of time-since-infection given being tested and the distribution of time-to-testing given being infected. The trend in the proportions of recent infections identifies the time-to-testing distribution, which would have not been identifiable based on HIV surveillance data alone, and makes back-calculation possible. The integration of the proportions of recent infections among newly diagnosed HIV into the model allows a probabilistic interpretation of the estimated proportions of recent infections based on the results of laboratory tests, in terms of the estimated distribution of the time-since-infection given being tested.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.