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Serbian Journal of Dermatology and Venereology

The Journal of Serbian Association of Dermatovenereologists (SAD)

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Myofibroblastic Dermatofibroma: An Unusual Variant / Miofibroblastni Dermatofibrom: Neuobičajena Varijacija

Cynthia Okoduwa1 / Robyn D. Siperstein1 / Wen Chen1 / Rajit Malliah1 / Valerie Fitzhugh1 / W. Clark Lambert1 / 1

1Dermatology and Pathology, New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103

This content is open access.
(CC BY-NC-ND 4.0)

Citation Information: Serbian Journal of Dermatology and Venerology. Volume 1, Issue 1, Pages 34–37, ISSN (Print) 1821-0902, DOI: 10.2478/v10249-011-0099-4, February 2013

Publication History:
Published Online:
2013-02-12

Abstract

Myofibroblastic dermatofibroma (MFD) is an unusual neoplasm characterized by a predominance of myofibroblastic differentiation. It is extremely rare and it is not well described. Expressions of smooth muscle actin, CD34, S-100, desmin, CD31, and Factor XIIIa were evaluated along with hematoxylin-eosin and trichrome staining of fixed tissue specimens from a fibrohistiocytic neoplasm. The neoplasm demonstrated a storiform pattern characteristic of fibrohistiocytic origin. It was strongly and diffusely positive for smooth muscle actin and vimentin, and negative for all other stains performed. A trichrome stain showed the entire tumor to be blue, demonstrating the collagenous and fibrous tissue to a marked degree. MFD is a distinct variant of dermatofibroma characterized by a predominance of myofibroblastic differentiation.

Sažetak

Uvod: Miofbroblastni dermatofbrom (MFD) neobičan je tumor karakterističan po tome što kod njega preovladava miofbroblastna diferencijacija. Veoma je redak i nedovoljno opisan u literaturi.

Metode: Ispitivanje je obuhvatilo ekspresiju aktina glatkih mišića, CD34, S-100, dezmin, CD31 i faktor XIIIa, kao i histopatološke analize hematoksilin-eozin i trihromnim bojenjem fksiranih uzoraka tkiva fbro-histiocitnih tumora.

Rezultati: Histopatološki, tumor se sastojao od vretenastih ćelija, karakterističnih za fbrohistiocitno poreklo. Imunohemijskom analizom dobijena je pozi-tivna reakcija na aktin i vimentin glatkih mišića, dok je na ostala bojenja reakcija bila negativna. Trihrom-nim bojenjem dobijena je potpuna obojenost tumora plavom bojom, što je do određene granice demonstri-ralo i kolagenozno i fbrozno tkivo.

Zaključak: MFD je posebna varijanta dermatofbroma sa karakterističnim prisustvom miofbroblastne diferen-cijacije.

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