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Turkish Journal of Pathology

The Journal of Federation of Turkish Pathology Societies 

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Histopathologic Analysis of Female Genital Tuberculosis: A Fifteen-Year Retrospective Study of 110 Cases in Eastern India / Kadın Genital Sistem Tüberkülozu: Hindistan’da 110 Olgunun Retrospektif Histopatolojik Analizi

1Department of Pathology, Medical College, KOLKATA, INDIA

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(CC BY-NC-ND 4.0)

Citation Information: Turkish Journal of Pathology. Volume 29, Issue 1, Pages 41–45, ISSN (Online) 1309-5730, DOI: 10.5146/tjpath.2013.01146, March 2013

Publication History:
Published Online:
2013-03-30

Abstract

Objective: Tuberculosis remains a global health problem and is an important cause of morbidity and mortality. Female genital tuberculosis is rare in the western world, but relevant in developing countries like India. Th e aim of this study was to determine histologic findings of diff erent parts of the female genital tract aff ected by tuberculosis and to correlate it with other features.

Material and Method: A total number of 110 cases of female genital tuberculosis from 92 patients were included over a period of 15 years. Th e age range of the patients was 17 to 45 years with a mean of 26.3. Th e diagnostic procedures used were curettage biopsy, hysterectomy, histologic examination, culture, Mycobacterium Tuberculosispolymerase chain reaction, laparoscopy, hysterosalpingography and ultrasonography.

Results: Patients with female genital tuberculosis presented with infertility (65-70%), pelvic/ abdominal pain (50-55%) and menstrual disturbances (20-25%). Female genital tuberculosis involved the vulva (2), vagina (1), cervix (5), endometrium (66), fallopian tube (24) and ovaries (12). Out of 66 endometrial tuberculosis cases, proliferative, secretory endometrium and atrophic endometrium were seen in 53, 9, and 4 cases, respectively. HIV co-infection was found only in 5 cases and acid-fast bacilli in tissue sections were detected in 7 cases.

Conclusion: Female genital tuberculosis is not uncommon in developing countries and is an important cause of infertility. Th ough the fallopian tube was the most common site in many studies, the endometrium was the commonest site in this study.

ÖZ

Amaç: Tuberkuloz evrensel bir sağlık sorunudur ve onemli mortalite ve morbidite nedenidir. Batı dunyasında nadir olmakla birlikte kadın genital sistemi tuberkulozu Hindistan gibi gelişmekte olan ulkelerde gundemdedir. Bu calışmada, kadın genital sistemi tuberkulozunun histolojik ozellikleri ve diğer bulgular ile ilişkisi araştırılmaktadır.

Gereç ve Yöntem: Onbeş yıllık donemde tanı konan toplam 92 olguda 110 kadın genital sistemi tuberkulozu calışmaya alınmıştır. Olguların yaşları 17-45 arasında değişmekteydi ve ortalama yaş 26,3 olarak gozlendi. Tanıda kuretaj biyopsi, histerektomi, histolojik inceleme, kultur, Mycobacterium tuberculosis - Polimeraz Zincir Reaksiyonu, laparoskopi, histerosalpingografive ultrasonografikullanılmıştı.

Bulgular: Kadın genital sistemi tuberkulozu olguları infertilite (%65- 70), pelvik/ abdominal ağrı (%50-55) ve menstrual yakınmalarla (%20-25) başvurmuşlardı. Kadın genital sistemi tuberkulozu vulva (2), vajina (1), serviks (5), endometrium (66), tuba (24) ve ovaryumları (12) tutmuştu. Olguların 66’sında endometrium tuberkulozu yanısıra proliferatif, sekretuvar ve atrofik endometrium gozlendi (sırasıyla 53, 9, 4 olgu). Sadece 5 olguda HIV ko-enfeksiyonu gozlendi. Olguların 7’sinde doku kesitlerinde asit fast basil saptandı.

Sonuç: Kadın genital sistemi tuberkulozu gelişmekte olan ulkelerde nadir değildir ve infertilitenin onemli bir nedenidir. Coğu calışmada tubular en sık tutulan organ olmasına karşılık, calışmamızda endometrium en sık tutulan organ olarak dikkati cekmektedir

Keywords : Tuberculosis; Female genital; Histopathology; HIV

Anahtar Sözcükler : Tuberkuloz; Kadın genital; Histopatoloji; HIV

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