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Translational Neuroscience

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Malignant transformation of grade II ganglioglioma to glioblastoma: A case report

1University Hospital Sestre milosrdnice, Zagreb, Croatia

© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Translational Neuroscience. Volume 3, Issue 2, Pages 213–216, ISSN (Online) 2081-6936, ISSN (Print) 2081-3856, DOI: 10.2478/s13380-012-0017-x, June 2012

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Gangliogliomas are well differentiated and slowly growing neuroepithelial tumors composed of neoplastic ganglion cells and neoplastic glial cells corresponding mostly to the World Health Organization grade I tumors. However, some of these tumors disclose histologically more malignant glial component and correspond to grade II or grade III tumors. We report a case of left temporal lobe tumor in a 42-year-old woman fulfilling the diagnostic criteria for atypical (grade II) ganglioglioma with high Ki-67 proliferation index and p53 immunoreactive tumor cells. In spite of gross total removal of the tumor, it recurred eight months after surgery. Histopathological examination of the recurrent tumor revealed that it had undergone malignant transformation into a glioblastoma. This case indicates that gangliogliomas with high Ki-67 proliferating index and p53 immunoreactivity should be carefully monitored for recurrence and malignant progression regardless of their morphological grading and seemingly total surgical removal.

Keywords: Ganglioglioma; Malignant transformation; Glioblastoma

  • [1] Kleihues P., Cavenee W.K., Pathology and genetics of tumours of the nervous system, IARC Press, Lyon, 2007

  • [2] Majores M., von Leche M., Fassunke J., Schramm J., Becker J.A., Simon M., Tumor recurrence and malignant progression of gangliogliomas, Cancer, 2008, 113, 3355–3363 [CrossRef]

  • [3] Luyken C., Blumcke I., Fimmers R., Urbach H., Wiestler O.D., Schramm J., Supratentorial gangliogliomas: histopathological grading and tumor recurrence in 184 patients with median follow-up of 8 years, Cancer, 2004, 101, 146–155

  • [4] Castillo M., Gangliogliomas: ubiquitous or not?, Am. J. Neuroradiol., 1998, 19, 807–809

  • [5] Wolf H.K., Muller M.B., Spanle M., Zenther J., Scheramm J., Weistler O.D., Ganglioglioma: a detailed histopathological and immunohistochemical study, Acta Neuropathol. (Berl.), 1994, 88, 166–173 [CrossRef]

  • [6] Blumcke I., Weistler O.D., Gangliogliomas: an intriguing tumor entity associated with focal epilepsies, J. Neuropathol. Exp. Neurol., 2002, 61, 575–584

  • [7] Rumana C.S., Valadka A.B., Radiation therapy and malignant degeenration of benign supratentorial gangliogliomas, Neurosurgery, 1998, 42, 1038–1043 [CrossRef]

  • [8] Hayashi Y., Iwato M., Hasegawa M., Tachibana O., von Deimling A., Yamashita J., Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report., J. Neurosurg., 2001, 95, 138–142 [CrossRef]

  • [9] Jay A., Squire J., Becker L.E., Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Report of a case with flow cytometric and cytogenetic analysis., Cancer, 1994, 73, 2862–2868<2862::AID-CNCR2820731133>3.0.CO;2-5 [CrossRef]

  • [10] Kalyan-Raman U.P., Olivero W.C., Ganglioglioma: a correlative clinicopathological and radiological study often surgically treated cases with follow-up, Neurosurgery, 1987, 20, 428–433 [CrossRef]

  • [11] Kim N.R., Wang K.-C., Bang J.-S., Choe G., Park Y., Kim S.-K., et al., Glioblastomaotus transformation of ganglioglioma: case report with reference to molecular genetic and flow cytometric analysis, Pathol. Int., 2003, 53, 874–882 [CrossRef]

  • [12] Pandita A., Balasubramaniam A., Perrin R., Shannon P., Guha A., Malignant and benign ganglioglioma: a pathological and molecular study, Neuro Oncol., 2007, 9, 124–134 [CrossRef]

  • [13] Hirose T., Kannuki S., Nishida K., Matsumoto K., Sano T. and Hizawa K., Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells, Acta Neuropathol. (Berl.), 1992, 83, 365–370 [CrossRef]

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