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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

12 Issues per year


IMPACT FACTOR 2014: 0.744

SCImago Journal Rank (SJR) 2013: 0.306
Source Normalized Impact per Paper (SNIP) 2013: 0.506

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BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity

Frank Postleb1 / Danuta Stefanik2 / Harald Seifert2 / 1

1Universität zu Köln, Department für Chemie, Greinstr. 4, 50939 Köln, Germany

2Universität zu Köln, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Goldenfelsstr. 19 – 21, 50935 Köln, Germany

Citation Information: Zeitschrift für Naturforschung B. Volume 68, Issue 10, Pages 1123–1128, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: 10.5560/znb.2013-3150, June 2014

Publication History

Received:
2013-06-07
Published Online:
2014-06-02

We have synthesized twelve new ionic liquids composed of an imidazolium-based cation in combination with an anion that shows antiobiotic or analgesic activity. These “BIOnic Liquids” have been tested towards their antibiotic activity in a standardized microbiological assay. A surprizingly large number of compounds shows high activity towards a set of bacteria which cannot be explained as simple cumulative effects. The general concept opens up completely new possibilities for the future development of pharmaceutically active compounds.

Graphical Abstract

BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity

Keywords: Ionic Liquids; Active Pharmaceutical Ingredients (API); Imidazolium Salts; Antibiotics; Antimicrobials; Analgesics

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[1]
A. Reinhardt, M. Horn, J. Pieper gen. Schmauck, A. Bröhl, R. Giernoth, C. Oelkrug, A. Schubert, and I. Neundorf
Bioconjugate Chemistry, 2014, Volume 25, Number 12, Page 2166

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