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Publication Date:
November 2013
ISBN:
978-83-7656-056-4

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eBook (PDF)
Open Access
Hardcover
RRP
€ [D] 189.95
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US$ 266.00 *
*Prices subject to change. Shipping costs will be added if applicable.

Stark, Holger

Histamine H4 receptor

a Novel Drug Target For Immunoregulation and Inflammation

DE GRUYTER OPEN

    Open Access

    G protein coupled receptors, Histamine H4R ligands, Inflammation and Autoimmune Disorders

    Aims and Scope

    H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer.
    Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

    Supplementary Information

    368 pages
    DE GRUYTER OPEN
    Language:
    English
    Type of Publication:
    Monograph
    Keywords:
    G protein coupled receptors, H4R ligands, Inflammation, Autoimmune Disorders, Pruritus, Asthma, Allergy, Cancer, Drug Development, Drug Target, Clinical Candidates, Biogenic Amin

    MARC record

    MARC record for eBook

    Holger Stark, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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