Skip to content
Should you have
institutional access?
Here's how to get it ...
€ EUR - Euro
£ GBP - Pound
$ USD - Dollar
EN
English
Deutsch
0
Subjects
Skip section
Browse Publications By Subject
Architecture and Design
Arts
Asian and Pacific Studies
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Islamic and Middle Eastern Studies
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
For Authors
Skip section
For Journal Authors
Publish your article
The role of authors
Promoting your article
Abstracting & indexing
Publishing Ethics
For Book Authors
Why publish with De Gruyter
How to publish with De Gruyter
Our book series
Our subject areas
For Database Authors
Your digital product at De Gruyter
Contribute to our reference works
Services
Skip section
For Librarians
Product information
Tools & resources
FAQs
Contacts
For Book Sellers & Library Suppliers
Product Information
Promotional Materials
Orders and Inquiries
FAQ for Library Suppliers and Book Sellers
Rights & Permissions
Repository Policy
Free access policy
Publications
Skip section
Open Access
Books
Articles
Open Access agreements
Publication types
Books
Journals
Databases
Database portals
Subjects we publish
Architecture and Design
Arts
Asian and Pacific Studies
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Islamic and Middle Eastern Studies
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
About
Skip section
Contact
For Authors
Customer service
People + Culture
Press
Sales
Journal Management
Partner Publishers
Open Access
Advertising
Review Copies
Inspection Copies
Legal
Career
How to join us
Vacancies
Working at De Gruyter
About De Gruyter
Mission & Vision
Imprints
History
De Gruyter Foundation
De Gruyter Ebound
Locations
Our Responsibility
Partnerships
Partner publishers
Press
FAQs
0
SUBJECTS
Browse Publications By Subject
Architecture and Design
Arts
Asian and Pacific Studies
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Islamic and Middle Eastern Studies
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
FOR AUTHORS
For Journal Authors
Publish your article
The role of authors
Promoting your article
Abstracting & indexing
Publishing Ethics
For Book Authors
Why publish with De Gruyter
How to publish with De Gruyter
Our book series
Our subject areas
For Database Authors
Your digital product at De Gruyter
Contribute to our reference works
SERVICES
For Librarians
Product information
Tools & resources
FAQs
Contacts
For Book Sellers & Library Suppliers
Product Information
Promotional Materials
Orders and Inquiries
FAQ for Library Suppliers and Book Sellers
Rights & Permissions
Repository Policy
Free access policy
PUBLICATIONS
Open Access
Books
Articles
Open Access agreements
Publication types
Books
Journals
Databases
Database portals
Subjects we publish
Architecture and Design
Arts
Asian and Pacific Studies
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Islamic and Middle Eastern Studies
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
ABOUT
Contact
For Authors
Customer service
People + Culture
Press
Sales
Journal Management
Career
How to join us
Vacancies
Working at De Gruyter
About De Gruyter
Mission & Vision
Imprints
History
De Gruyter Foundation
De Gruyter Ebound
Locations
Our Responsibility
Partnerships
Partner publishers
Press
FAQs
Change language
English
Deutsch
Change currency
€ EUR
£ GBP
$ USD
Your purchase has been completed. Your documents are now available to view.
Licensed
Unlicensed
Requires Authentication
Published by
De Gruyter
Volume 26 Issue 3
Issue of
Neuroforum
Contents
Journal Overview
Contents
Unable to retrieve citations for this document
Retrieving citations for document...
Publicly Available
September 21, 2020
Frontmatter
Page range: i-iii
Cite this
Download PDF
Editorial
Unable to retrieve citations for this document
Retrieving citations for document...
Publicly Available
September 21, 2020
Editorial
Onur Güntürkün
Page range: 131-132
Cite this
Download PDF
Review articles
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
August 3, 2020
Stress modulation of fear and extinction in psychopathology and treatment
Shira Meir Drexler, Christian J. Merz, Valerie L. Jentsch, Oliver T. Wolf
Page range: 133-141
More
Cite this
Download PDF
Abstract
The glucocorticoid cortisol, a major player in the development of stress-related psychopathology, can also be used for the augmentation of extinction-based psychotherapies (e.g., exposure therapy). Substantial evidence supports its beneficial effects in the treatment of post-traumatic stress disorder and specific phobias. In this review, we first present the role of stress and cortisol in the development of maladaptive emotional memories. Then, we describe the mechanisms that may account for the cortisol-induced augmentation of exposure, namely, the enhancement of extinction memory consolidation and the reduction of the contextual dependency of the extinction memory. Finally, we discuss several considerations and limitations for the use of cortisol in psychotherapy, focusing on the possible adverse effects of cortisol in a reconsolidation-based (as opposed to extinction-based) intervention.
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
August 6, 2020
Clinical implications of fear extinction in anxiety disorders
Armin Zlomuzica, Silvia Schneider, Carolin Konrad, Christian J. Merz, Oliver T. Wolf, Friederike Raeder, Jürgen Margraf
Page range: 143-149
More
Cite this
Download PDF
Abstract
Anxiety disorders (ADs) are characterized by increased chronicity and comorbidity with other ADs. Although exposure is the most effective therapy option for ADs, some patients show poor treatment response and a heightened vulnerability for relapse after treatment completion. Hence, significant research effort needs to be devoted to improve the long-term effectiveness of exposure effects. Recent attempts to increase exposure therapy efficacy use strategies aimed at promoting the acquisition and retrieval of extinction memories. The present review illustrates the value and limitations of such extinction-based therapy approaches. We present and discuss recent findings from translational studies using cortisol and self-efficacy enhancement as an add-on to exposure therapy. We illustrate how the integration of findings from experimental research on fear extinction learning and self-efficacy could advance the development of more optimized treatments for ADs.
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
August 12, 2020
From gut feelings to memories of visceral pain
Sigrid Elsenbruch, Sven Benson, Laura Ricarda Koenen, Franziska Labrenz, Adriane Icenhour
Page range: 171-177
More
Cite this
Download PDF
Abstract
The role of pain-related fear learning and memory processes, conceptually embedded within the fear-avoidance model of chronic pain, is increasingly recognized. The unique biological salience of interoceptive, visceral pain with its cognitive, emotional, and motivational facets fosters associative learning. Conditioned fear is in principle adaptive but may turn maladaptive and contribute to hypervigilance and hyperalgesia in chronic pain. This review summarizes current knowledge on the formation, extinction, and return of pain-related memories with a focus on visceral pain. It provides a conceptual background, describes experimental approaches, and summarizes findings on behavioral and neural mechanisms in healthy humans and patients with chronic pain. Future directions underscore the potential of refining knowledge on the role of associative learning in the pathophysiology and treatment of chronic visceral pain in disorders of gut–brain interactions such as irritable bowel syndrome.
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
August 17, 2020
Principles of extinction learning of nonaversive experience
Metin Uengoer, Silke Lissek, Martin Tegenthoff, Denise Manahan-Vaughan, Harald Lachnit
Page range: 151-159
More
Cite this
Download PDF
Abstract
This review outlines behavioral and neurobiological aspects of extinction learning, with a focus on nonaversive experience. The extinction of acquired behavior is crucial for readaptation to our environment and plays a central role in therapeutic interventions. However, behavior that has been extinguished can reappear owing to context changes. In the first part of the article, we examine experimental strategies aimed at reducing behavioral recovery after extinction of nonaversive experience, focusing on extinction learning in multiple contexts, reminder cues, and the informational value of contexts. In the second part, we report findings from human imaging studies and studies with rodents on the neural correlates of extinction and response recovery in nonaversive learning, with a focus on ventromedial prefrontal cortex, hippocampus, and neurotransmitter systems.
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
July 31, 2020
Beyond the classic extinction network: a wider, comparative view
Onur Güntürkün, Maik C. Stüttgen, Sarah Starosta, Roland Pusch, Meng Gao, Michael Nitsche, Thomas M. Ernst, Mark E. Ladd, Harald H. Quick, Dagmar Timmann
Page range: 161-169
More
Cite this
Download PDF
Abstract
Extinction learning modifies the dynamics of brain circuits such that a previously learned conditioned response is no longer generated. The majority of extinction studies use fear conditioning in rodents and identified the prefrontal cortex, the hippocampus, and the amygdala as core regions of the extinction circuit. We sought to find answers to two questions: First, do we find a similar functional brain circuit in birds, which underwent a 300-million-year separate evolution from mammals? Second, do we have to incorporate the cerebellum as a key component of the central extinction circuit? We indeed show that the avian extinction pathways are not identical but highly similar to those of mammals. In addition, we reveal that the human cerebellum processes prediction errors, a key element driving extinction of learned fear responses, and contributes to context-related effects of extinction.
Unable to retrieve citations for this document
Retrieving citations for document...
Open Access
August 31, 2020
How learning shapes immunity
Martin Hadamitzky, Laura Lückemann, Manfred Schedlowski, Harald Engler
Page range: 179-184
More
Cite this
Download PDF
Abstract
Experimental studies in rodents and humans have convincingly demonstrated that immune functions can be modulated by associative learning processes. We have established a conditioned taste avoidance (CTA) paradigm in rats by pairing a novel taste (conditioned stimulus, CS) with an injection of the immunosuppressive drug cyclosporine A (CsA; unconditioned stimulus, US). Re-exposure to the CS results in a pronounced CTA and, more importantly, in a selective suppression of specific T-cell functions, mimicking the drugs’ effects. To provide a basis for using learned immunosuppressive strategies in clinical situations, we are currently investigating the neurobiological mechanisms underlying the extinction of conditioned immunosuppressive responses and the generalizability of our findings to other immunomodulatory drugs.
Presentation of scientific institutions
Unable to retrieve citations for this document
Retrieving citations for document...
Publicly Available
September 21, 2020
Forschungskolleg “NeurodegX”
Kristina Endres, Simone Eggert
Page range: 185-186
Cite this
Download PDF
Nachrichten aus der Gesellschaft
Unable to retrieve citations for this document
Retrieving citations for document...
Publicly Available
September 1, 2020
Nachrichten aus der Gesellschaft
Page range: 187-191
Cite this
Download PDF
Journal Overview
About this journal
This journal has ceased publication. Neuroforum was published from 1995 till 2022. It was the official journal of the German Neuroscience Society (GNS) / Neurowissenschaftliche Gesellschaft e.V. (NWG).
The main scientific articles of Neuroforum will appear in solely electronic form on the web portal dasGehirn.info (
https://www.dasgehirn.info/
) starting in 2023.
This issue
All issues
Downloaded on 28.3.2024 from https://www.degruyter.com/journal/key/nf/26/3/html