Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter July 5, 2005

Comparison of iodine contents in gastric cancer and surrounding normal tissues

  • Mine Gulaboglu , Leyla Yildiz , Fehmi Celebi , Mustafa Gul and Kemal Peker

Abstract

It has been suggested that iodine plays an important role in gastric cancer. Gastric cancer ranks first among the cancers in the north-eastern Anatolia region, Turkey, where iodine deficiency is common. In this study, iodine levels were determined in gastric cancer and surrounding normal tissues in 19 patients with gastric cancer. Tissue iodine levels were determined by the Foss method based on the Sandell-Kolt-hoff reaction. Tissue iodine levels were lower in gastric cancer tissue (17.8±3.4ngI/mg protein, mean±SEM) compared with surrounding normal tissue (41.7±8.0ngI/mg protein) (p<0.001). There was positive correlation between the iodine levels in gastric cancer tissue and surrounding normal tissue (r=0.845, p<0.001). There was no significant difference in iodine levels in cancer and surrounding normal tissue between male and female subjects. The iodine deficiency in our region may be one of the factors for increased gastric cancer prevalence. Our results support the hypothesis that iodine plays an important role in gastric cancer development.


Corresponding author: Mine Gulaboglu, PhD, Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey Phone: +90-442-2360961, Fax: +90-442-2360962,

References

1 Biber FZ, Unak P, Yurt F. Stability of iodine content in iodized salt. In: Presentations at the Eurasia Conference on Nuclear Science and its Application, vol. 1, 2000:1073–7. Search in Google Scholar

2 Venturi S, Donati FM, Venturi M, Venturi A, Grossi L, Guidi A. Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach. Adv Clin Pathol 2000; 4: 11–7. Search in Google Scholar

3 Venturi S, Venturi A, Cimimi D, Arduini C, Venturi M, Guidi A. A new hypothesis: iodine and gastric cancer. Eur J Cancer Prev 1993; 2: 17–23. 10.1097/00008469-199301000-00004Search in Google Scholar

4 Kupper FC, Schweigert N, Gall E, Legendre JM, Vilter H, Kloareg B. Iodine uptake in Laminariales involves extra-cellular haloperoxidase-mediated oxidation of iodide. Planta 1998; 207: 163–71. 10.1007/s004250050469Search in Google Scholar

5 Venturi S, Venturi M. Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant? Eur J Endocrinol 1999; 140: 371–2. 10.1530/eje.0.1400371Search in Google Scholar

6 Elstner EF, Adamczyk R, Kromer R, Furch A. The uptake of potassium iodide and its effects as an antioxidant in isolated rabbit eyes. Ophthalmologica 1985; 191: 122–6. 10.1159/000309572Search in Google Scholar

7 Stocks P. Cancer and goitre. Biometrica 1924; 16: 364–401. 10.1093/biomet/16.3-4.364Search in Google Scholar

8 Spencer JG. The influence of the thyroid gland in malignant disease. Br J Cancer 1954; 8: 393–411. 10.1038/bjc.1954.41Search in Google Scholar

9 Eskin BA. Iodine metabolism and breast cancer. Ann NY Acad Sci 1970; 32: 911–47. Search in Google Scholar

10 Eskin BA. Dietary iodine and cancer risk. Lancet 1976; 8: 807–8. 10.1016/S0140-6736(76)90646-2Search in Google Scholar

11 Venturi S, Marani L, Magni MA. Syndrome thyro-gastric. Study on the relation between elementary iodine deficiency and gastric cancer. In: Ghironzi G, Jackson CE, Schuman BM, editors. Epidemiology prevention and early detection of gastric cancer. Rome: CIC, 1987:279–81. Search in Google Scholar

12 Scriba PC, Beckers C, Bürgi H, Escobar DR, Gembicki M, Koutras DA, et al. Goitre and iodine deficiency in Europe. Lancet 1985; 325: 1289–93. Search in Google Scholar

13 Akarsu E. Iodine deficiency and goiter prevalence in adults living in Erzurum [in Turkish]. Thesis. Ataturk University, 2000. Search in Google Scholar

14 WHO-UNICEF-ICCIIDD. Indicators for assessing iodine deficiency disorders and their control through salt iodination. Document WHO/NUT/1994. Search in Google Scholar

15 Bakan E, Taysi S, Polat MF, Dalga S, Umudum Z, Bakan N, et al. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 2002; 32: 162–6. 10.1093/jjco/hyf035Search in Google Scholar

16 Gulaboglu M. The comparison of blood, urine and gastric tissue iodine levels in patients with gastric cancer [in Turkish]. PhD Thesis. Ataturk University, 2004. Search in Google Scholar

17 Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EW, O'Higgins NJ, et al. Tissue iodine content and serum-mediated I 125 uptake – blocking activity in breast cancer. J Clin Endocrinol Metab 2000; 85: 1245–50. Search in Google Scholar

18 Lauber K. Iodine determination in biological material, kinetic measurement of the catalytic activity of iodide. Anal Chem 1975; 47: 769–71. 10.1021/ac60354a023Search in Google Scholar

19 Foss OP, Hankes LV, Slyke DV. A study of the alkaline ashing method for determination of protein-bound iodine in serum. Clin Chim Acta 1960; 5: 301–26. 10.1016/0009-8981(60)90135-2Search in Google Scholar

20 Official methods of analysis, 14th ed. Washington, DC: Association of Official Analytical Chemists, 1990. Search in Google Scholar

21 Lampertico P. Pathology of the thyroid gland in Italy: final remarks. Pathologica 1982; 74: 400–19. Search in Google Scholar

22 Venturi S, Gross L, Marra GA, Venturi A, Venturi M. Iodine, Helicobacter pylori, stomach cancer, evolution. European Epi-Marker 2003; 7: 1–7. Search in Google Scholar

23 ISPEL. Mortalita per professioni in Italia negli anni 80 [in Italian]. Rome: Istituta Poligrafico dello Stato, 1995. Search in Google Scholar

24 Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, et al. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004; 96: 1577–84. 10.1093/jnci/djh296Search in Google Scholar

25 Bjelakovic G, Nikolova D, Simonetti G, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004; 364: 1219–28. 10.1016/S0140-6736(04)17138-9Search in Google Scholar

26 Gursan N, Albayrak A, Gursan MS, Keles M. Gastric carcinomas in Erzurum region. Turk J Gastroenterol 2001; 4: 294–8. Search in Google Scholar

27 Spitzweg C, Joba W, Eisenmenger W, Heufelder AE. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland and gastric mucosa. J Clin Endocrinol Metab 1998; 83: 1746–51. 10.1210/jcem.83.5.4839Search in Google Scholar PubMed

28 Spitzweg C, Morris JC. The sodium iodine symporter: its pathophysiological and therapeutic implications. Clin Endocrinol 2002; 57: 559–81. 10.1046/j.1365-2265.2002.01640.xSearch in Google Scholar PubMed

29 Venturi S, Venturi M. Does iodine in the gastric mucosa have an ancient antioxidant role? IDD Newsl 1998; 14: 61–2. Search in Google Scholar

30 Cocchi M, Venturi S. Iodide, antioxidant function and omega-6 and omega-3 fatty acids: a new hypothesis of a biochemical cooperation? Prog Nutr 2000; 2: 15–9. Search in Google Scholar

31 Banerjee RK, Bose AK, Chakraborty TK, De SK, Datta AG. Peroxidase-catalysed iodotyrosine formation in dispersed cells of mouse extrathyroidal tissue. J Endocrinol 1985; 106: 159–65. 10.1677/joe.0.1060159Search in Google Scholar PubMed

32 Weetman AP, McGregor AM, Campbell H, Lazarus JH, Ibbertson HK, Hall R. Iodide enhances Ig-G synthesis by human peripheral blood lymphocytes in vitro. Acta Endocrinol (Copenh) 1983; 103: 210–5. 10.1530/acta.0.1030210Search in Google Scholar PubMed

33 Trafford D. How to prevent and how to survive breast cancer. http://www.Trafford.com/4.dcgi/robots/01.0286.html (accessed21 February 2003). Search in Google Scholar

34 Ingbar SH, Woeber KA. The thyroid gland. In: Williams R, editor. Textbook of endocrinology, 6th ed. New York: Wiley, 1980:118–23. Search in Google Scholar

35 Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y. “Endemic coast goiter” in Hokkaido, Japan. Acta Endocrinol 1965; 50: 161–70. 10.1530/acta.0.0500161Search in Google Scholar

36 Ma T, Yu ZH, Lu TZ, Wang SY, Dong CF, Hu XY, et al. High-iodide endemic goitre. Chin Med J 1982; 95: 692–6. Search in Google Scholar

Received: 2005-1-11
Accepted: 2005-4-1
Published Online: 2005-7-5
Published in Print: 2005-6-1

© Walter de Gruyter Berlin New York

Downloaded on 28.3.2024 from https://www.degruyter.com/document/doi/10.1515/CCLM.2005.101/html
Scroll to top button