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Licensed Unlicensed Requires Authentication Published by De Gruyter December 20, 2014

Adenosine deaminase, dipeptidyl peptidase-IV activities and lipid peroxidation are increased in the saliva of obese young adult

  • Eduardo Ottobelli Chielle , Gabriela Bonfanti , Karine Santos De Bona , Rafael Noal Moresco and Maria Beatriz Moretto EMAIL logo

Abstract

Background: Obesity is the hallmark of the metabolic syndrome representing a major global health problem. It is considered a state of chronic inflammation with minimal exploration of salivary biomarkers. Thus, the intent of the present study was to assess the activities of salivary dipeptidyl peptidase IV (DPP-IV), adenosine deaminase (ADA) and lipid peroxidation in obese young and overweight young subjects.

Methods: ADA, DPP-IV activities and lipid peroxidation were investigated in saliva, as well as insulin, glucose, HbA1c, HOMA and anthropometric measurements in 149 young adults, including 54 with normal weight, 27 overweight and 68 obese subjects.

Results: Salivary ADA and DPP-IV activities as well as lipid peroxidation were higher in patients with obesity compared to the normal weight group. Correlations between ADA/DPP-IV activities, lipid peroxidation/ADA activity, ADA activity/hip circumference and BMI/weight were observed.

Conclusions: Our results indicate that the increase in the salivary ADA and DPP-IV activities as well as in the lipid peroxidation could be related of the regulation to various aspects of adipose tissue function and inflammatory obesity. It is suggested that these salivary biomarkers may be used as biochemical test in clinical abnormalities present in obesity, in the absence of oral inflammatory diseases.


Corresponding author: Maria Beatriz Moretto, Postgraduate Program in Pharmaceutical Sciences, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900 Santa Maria, RS, Brazil, Fax: +55 3220 8018, E-mail:

Acknowledgments

The authors wish to thank the Federal University of Santa Maria (UFSM), and University of West of Santa Catarina (UNOESC), SC, Brazil, for support in this study. Also, we thank all the volunteers who participated in this study.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Financial support: The work had the financial support of the Brazilian National Research Council (CNPq), Universal no 477029/2011-6.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2014-11-5
Accepted: 2014-11-20
Published Online: 2014-12-20
Published in Print: 2015-6-1

©2015 by De Gruyter

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