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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Cytotoxic Abietane Diterpenes from Hyptis martiusii Benth.

  • Edigênia Cavalcante da Cruz Araújo , Mary Anne S. Lima , Raquel C. Montenegro , Marcelle Nogueira , Letícia V. Costa-Lotufo EMAIL logo , Cláudia Pessoa , Manoel Odorico de Moraes and Edilberto R. Silveira

From roots of Hyptis martiusii Benth. two tanshinone diterpenes were isolated, the new 7β-hydroxy-11,14-dioxoabieta-8,12-diene (1) in addition to the known 7α-acetoxy-12-hydroxy- 11,14-dioxoabieta-8,12-diene (7α-acetoxyroyleanone) (2). Structures of 1 and 2 were established by spectroscopic means. The cytotoxic activity against five cancer cell lines was evaluated. Compounds 1 and 2 displayed considerable cytotoxic activity against several cancer cell lines with IC50 values in the range of 3.1 to 11.5 μg/ml and 0.9 to 7.6 μg/ml, respectively. The cytotoxic activity seemed to be related to inhibition of DNA synthesis, as revealed by the reduction of 5-bromo-2′-deoxyuridine incorporation and induction of apoptosis, as indicated by the acridine orange/ethidium bromide assay and morphological changes after 24 h of incubation in leukemic cells.

Received: 2005-11-10
Published Online: 2014-6-2
Published in Print: 2006-4-1

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