Biotin interference in immunoassays mimicking subclinical Graves’ disease and hyperestrogenism: a case series

Marcelo C. Batista 1 , Carlos E.S. Ferreira 1 , 2 , Adriana C.L. Faulhaber 1 , Jairo T. Hidal 3 , Simão A. Lottenberg 1 ,  and Cristóvão L.P. Mangueira 1
  • 1 Clinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil
  • 2 Department of Laboratory Medicine, Universidade Federal de São Paulo – UNIFESP, São Paulo, Brazil
  • 3 Department of Endocrinology, Hospital Israelita Albert Einstein, São Paulo, Brazil
Marcelo C. Batista, Carlos E.S. Ferreira, Adriana C.L. Faulhaber, Jairo T. Hidal, Simão A. Lottenberg and Cristóvão L.P. Mangueira

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  • 1.

    Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128–38.

    • Crossref
    • PubMed
    • Export Citation
  • 2.

    European Commission, Scientific Committee on Food (ECSCF). 2001. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Biotin. European Commission, SCF/CS/NUT/UPPLEV/55 Final Report. Brussels. Available at: http://ec.europa.eu/food/fs/sc/scf/out106_en.pdf.

  • 3.

    Barbesino G. Misdiagnosis of Graves’ Disease with apparent severe hyperthyroidism in a patient taking biotin megadoses. Thyroid 2016;26:860–3.

    • Crossref
    • Export Citation
  • 4.

    Elston MS, Sehgal S, Du Toit S, Yarndley T, Conaglen JV. Factitious Graves’ disease due to biotin immunoassay interference – a case and review of the literature. J Clin Endocrinol Metab 2016;101:3251–5.

    • Crossref
    • PubMed
    • Export Citation
  • 5.

    Kummer S, Hermsen D, Distelmaier F. Biotin treatment mimicking Graves’ disease. N Engl J Med 2016;375:704–6.

    • Crossref
    • PubMed
    • Export Citation
  • 6.

    Diamandis EP, Christopoulos TK. The biotin-(strept)avidin system: principles and applications in biotechnology. Clin Chem 1991;37:625–36.

    • Crossref
    • PubMed
    • Export Citation
  • 7.

    Wijeratne NG, Doery JC, Lu ZX. Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study. Pathology 2012;44:674–5.

    • PubMed
    • Export Citation
  • 8.

    Kwok JS, Chan IH, Chan MH. Biotin interference on TSH and free thyroid hormone measurement. Pathology 2012; 44:278–80.

    • PubMed
    • Export Citation
  • 9.

    Meany DL, Jan de Beur SM, Bill MJ, Sokoll LJ. A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. Clin Chem 2009;55:1737–41.

    • Crossref
    • PubMed
    • Export Citation
  • 10.

    Waghray A, Milas M, Nyalakonda K, Siperstein AE. Falsely low parathyroid hormone secondary to biotin interference: a case series. Endocr Pract 2013;19:451–5.

    • Crossref
    • PubMed
    • Export Citation
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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.

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