Antidepressant use limits serotonin as a marker for neuroendocrine tumor disease activity by lowering of circulating serotonin concentrations

Huub H. van Rossum 1 , Jocelyn Spruit 2 , Catharina M. Korse 3 , Froukje E. de Vries 2 , and Margot E.T. Tesselaar 4
  • 1 Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • 2 Department of Psychiatry and the Center for Quality of Life, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • 3 Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • 4 Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Huub H. van Rossum
  • Corresponding author
  • Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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, Jocelyn Spruit
  • Department of Psychiatry and the Center for Quality of Life, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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, Catharina M. Korse
  • Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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, Froukje E. de Vries
  • Department of Psychiatry and the Center for Quality of Life, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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and Margot E.T. Tesselaar
  • Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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  • degruyter.comGoogle Scholar

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  • 1.

    Verbeek WH, Korse CM, Tesselaar ME. Gep-nets update: secreting gastro-enteropancreatic neuroendocrine tumours and biomarkers. Eur J Endocrinol 2016;174:R1–7.

    • Crossref
    • PubMed
    • Export Citation
  • 2.

    Kema IP, de Vries EG, Muskiet FA. Clinical chemistry of serotonin and metabolites. J Chromatogr B Biomed Sci Appl 2000;747: 33–48.

    • Crossref
    • PubMed
    • Export Citation
  • 3.

    Korse CM, Buning-Kager J, Linders TC, Heijboer AC, van den Broek D, Tesselaar ME, et al. A serum and platelet-rich plasma serotonin assay using liquid chromatography tandem mass spectrometry for monitoring of neuroendocrine tumor patients. Clin Chim Acta 2017;469:130–5.

    • Crossref
    • PubMed
    • Export Citation
  • 4.

    Peters MA, van Faassen M, de Jong WH, Bouma G, Meijer C, Walenkamp AM, et al. Use of selective serotonin reuptake inhibitors is associated with very low plasma free serotonin concentrations in humans. Ann Clin Biochem 2019; doi: . [Epub ahead of print].

    • Crossref
    • PubMed
    • Export Citation
  • 5.

    Abdelmalik N, Ruhe RG, Barwari K, van den Dool EJ, Meijers JC, Middeldorp S, et al. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. J Throm Haemost 2008;6:2168–74.

    • Crossref
    • Export Citation
  • 6.

    Linden W, Vodermaier A, Mackenzie R, Greig D. Anxiety and depression after cancer diagnosis: prevalence rates by cancer type, gender, and age. J Affect Disord 2012;141:343–51.

    • Crossref
    • PubMed
    • Export Citation
  • 7.

    van Faassen M, Bouma G, de Hosson LD, Peters MA, Kats-Ugurlu G, de Vries EG, et al. Quantitative profiling of platelet-rich plasma indole markers by direct-matrix derivatization combined with LC-MS/MS in patients with neuroendocrine tumors. Clin Chem 2019;65:1388–96.

    • Crossref
    • PubMed
    • Export Citation
  • 8.

    Kema IP, Schellings AM, Meiborg G, Hoppenbrouwers CJ, Muskiet FA. Influence of a serotonin- and dopamine-rich diet on platelet serotonin content and urinary excretion of biogenic amines and their metabolites. Clin Chem 1992;38:1730–6.

    • Crossref
    • PubMed
    • Export Citation
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