Investigating the preventive effect of vitamins C and E on preeclampsia in nulliparous pregnant women

  • 1 Gynecology Department, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • 2 Faculty of Dentistry, Biruni University, Istanbul, Turkey
  • 3 Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Nahid LorzadehORCID iD: https://orcid.org/0000-0003-1492-8582, Yasaman Kazemirad and Nastran Kazemirad

Abstract

Objectives

Preeclampsia is a hypertensive disorder associated with pregnancy and is the leading cause of both maternal and neonatal morbidity and mortality. Recent reports suggest that free radical-induced endothelial cell injury might be an etiologic factor in the pathogenesis of preeclampsia. The aim of this study was to determine the protective effects of vitamins C and E for the prevention of preeclampsia.

Methods

This clinical trial was conducted in the year 2018 in the clinical centers of Lorestan University of Medical Sciences. One hundred and sixty nulliparous women aged 18–38 years without any risk factors for preeclampsia were divided into two groups. The first group received a 400-IU/day dose of vitamin E orally and a 1000-mg/day dose of vitamin C with iron tablets during 20–24 weeks of pregnancy, while the control group received only iron tablets. Finally, the data were analyzed using descriptive statistics and frequency distribution tables.

Results

The incidence of preeclampsia in the control group was 17.5% and in the intervention group was 5%, which was significantly different. The mean systolic pressures before and after intervention were 99.43 ± 7.8 and 12.44 ± 19.1, respectively, in the control group, and 99.3 ± 8.3 and 106.12 ± 13.25, respectively, in the intervention group (P < 0.001). The mean diastolic pressures before and after intervention in the control group were 62.7 ± 13.6 and 62.7 ± 4.7 (P < 0.001), respectively.

Conclusion

The results of this study show that vitamins C and E have protective effects against preeclampsia by alleviating the overall blood pressure.

  • 1.

    Gibbs RS, Karlan BY, Haney AF, Nygaard IE. Danforth’s obstetrics and gynecology. Philadelphia, PA: Lippincott Williams & Wilkins; 2008.

  • 2.

    Baldwin NE, Chesler EJ, Kirov S, Langston MA, Snoddy JR, Williams RW, et al. Computational, integrative, and comparative methods for the elucidation of genetic coexpression networks. J Biomed Biotechnol 2005;2005:172–80.

    • Crossref
    • PubMed
    • Export Citation
  • 3.

    Lorzadeh N, Kazemirad S, Lorzadeh M, Najafi S. Comparison of the effect of oral and intravenous fluid therapy on women with oligohydramnios. Res J Obstet Gynecol 2008;1:25–9.

    • Crossref
    • Export Citation
  • 4.

    Lorzadeh N, Samimi S, Birjandi M. Association of fetal gender with maternal serum β-hCG and testosterone in normotensive and preeclamptic pregnancies. Iran J Obstet Gynecol Infertil 2010;13:13–9.

  • 5.

    Mannaerts D, Faes E, Cos P, Briede JJ, Gyselaers W, Cornette J, et al. Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PloS One 2018;13:e0202919.

    • Crossref
    • PubMed
    • Export Citation
  • 6.

    Lorzadeh N, Kazemirad S, Lorzadrh M, Dehnori A. A comparison of human chorionic gonadotropin with magnesium sulphate in inhibition of preterm labor. J Med Sci 2007;7:640–4.

    • Crossref
    • Export Citation
  • 7.

    Hall JE. Guyton and Hall textbook of medical physiology. Amsterdam, Netherlands: Saunders, an imprint of Elsevier Inc.; 2011.

  • 8.

    Lorzadeh N, Kazemirad S, Lorzadeh M. Urinary retention following the gynecologic surgeries and effect of Foley catheter clamping on its prophylaxis. J Med Sci 2007;7:1358e61.

  • 9.

    Palan PR, Mikhail MS, Romney SL. Placental and serum levels of carotenoids in preeclampsia. Obstet Gynecol 2001;98:459–62.

    • PubMed
    • Export Citation
  • 10.

    Nasrollahi S, Ali Mohammadi S, Zamani M. Effect of antioxidants (vitamins E and C) in reducing the incidence of pre-eclampsia in primiparous women. J Gorgan Univ Med Sc 2007;8:17–21.

  • 11.

    Yimcharoen M, Kittikunnathum S, Suknikorn C, Nak-On W, Yeethong P, Anthony TG, et al. Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise. J Int Soc Sports Nutr 2019;16:2.

    • Crossref
    • PubMed
    • Export Citation
  • 12.

    Mescic Macan A, Gazivoda Kraljevic T, Raic-Malic S. Therapeutic perspective of vitamin C and its derivatives. Antioxidants (Basel, Switzerland) 2019;8:247.

  • 13.

    Tantavisut S, Tanavalee A, Honsawek S, Suantawee T, Ngarmukos S, Adisakwatana S, et al. Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study. BMC Musculoskelet Disord 2017;18:281.

    • Crossref
    • PubMed
    • Export Citation
  • 14.

    Shennan AH, Duckworth S. Use of vitamin C and E to prevent preeclampsia. Obstet Med 2010;3:121–2.

    • Crossref
    • Export Citation
  • 15.

    Kalpdev A, Saha SC, Dhawan V. Vitamin C and E supplementation does not reduce the risk of superimposed PE in pregnancy. Hypertens Pregnancy 2011;30:447–56.

    • Crossref
    • Export Citation
  • 16.

    Ellis J, Wennerholm UB, Bengtsson A, Lilja H, Pettersson A, Sultan B, et al. Levels of dimethylarginines and cytokines in mild and severe preeclampsia. Acta Obstet Gynecol Scand 2001;80:602–8.

    • Crossref
    • PubMed
    • Export Citation
  • 17.

    Safari M, Yazdanpanah B. Prevalence of preeclampsia and its maternal and fetal complication in women referred to Emam Sajjad Hospital of Yasooj. J Sharkord Univ Med Sci 2001;5:47–53 [in Persian].

  • 18.

    Nikpour S, Atarodi Kashani Z, Mokhtarshahi S, Parsay S, Nooritajer M, Haghani H. Study of the correlation of the consumption of vitamin C-rich foods with preeclampsia and eclampsia in women referred to Shahid Akbar Abadi Hospital in Tehran, 2004. Razi J Med Sci 2007;14:179–92.

  • 19.

    Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810–6.

    • Crossref
    • Export Citation
  • 20.

    Chappell LC, Seed PT, Kelly FJ, Briley A, Hunt BJ, Charnock-Jones DS, et al. Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. Am J Obstet Gynecol 2002;187:777–84.

    • Crossref
    • Export Citation
  • 21.

    Mostajeran F, Taj AS. Determination the effect of supplemental antioxidant vitamin E, C on the prevention of preeclamcia in high risk pregnant women in Isfahan in 2006. Iran J Obstet Gynecol Infertil 2007;10:37–40.

  • 22.

    Taghriri A, Danesh A. Effects of vitamins E and C in reduction of preeclampsia blood pressure incidence in primigravids. J Shahrekord Univ Med Sci 2007;9:50–4.

  • 23.

    Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 2006;354: 1796–806.

    • Crossref
    • Export Citation
  • 24.

    Polyzos NP, Mauri D, Tsappi M, Tzioras S, Kamposioras K, Cortinovis I, et al. Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review. Obstet Gynecol Surv 2007;62:202–6.

    • Crossref
    • Export Citation
  • 25.

    Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ, et al. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med 2010;362:1282–91.

    • Crossref
    • Export Citation
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