Investigation of ischemia modified albumin and coenzyme Q10 levels in obese children with metabolic syndrome

Sabahattin Muhtaroğlu 1 , Selda Özkan Koçak 2 , İhsan Çetin 3 , Didem Barlak Keti 1  and Mustafa Kendirci 4
  • 1 Erciyes Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Bölümü, Kayseri, Turkey
  • 2 Erciyes Üniversitesi Tıp Fakültesi, Metabolizma Laboratuvarı, Kayseri, Turkey
  • 3 Batman Üniversitesi Sağlık Yüksek Okulu, Beslenme ve Diyetetik Bölümü, Batman, Turkey
  • 4 Erciyes Üniversitesi Tıp Fakültesi, Pediatrik Endokrinoloji Bölümü, Kayseri, Turkey
Sabahattin Muhtaroğlu, Selda Özkan Koçak, İhsan Çetin, Didem Barlak Keti and Mustafa Kendirci

Abstract

Introduction:

The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS).

Methods:

Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6–18 years were included in the study. Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC. Serum glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and insulin were analyzed.

Results:

IMA levels were found to be significantly higher (p<0.001) while the CoQ10 levels were significantly lower (p<0.001) in obese children with and without MS compared to controls. IMA and CoQ10 significantly correlated with each other and metabolic parameters. Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose, insulin levels and HOMA were significantly higher (p<0.001) in obese children with MS than obese without MS and controls.

Conclusions:

Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid peroxidation and cardiometabolic risk.

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Turkish Journal of Biochemistry (TJB), official journal of Turkish Biochemical Society, is issued electronically every 2 months. The main aim of the journal is to support the research and publishing culture by ensuring that every published manuscript has an added value and thus providing international acceptance of the “readability” of the manuscripts published in the journal.

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