The independent relationship between hemoglobin A1c and homeostasis model assessment of insulin resistance in non-diabetic subjects

Hulya Yalcin 1 , Burak Toprak 2  and Ayfer Colak 1
  • 1 Tepecik Teaching and Research Hospital, Department of Clinical Biochemistry, Izmir, Turkey
  • 2 Silopi State Hospital, Department of Clinical Biochemistry, Sirnak, Turkey
Hulya Yalcin, Burak Toprak and Ayfer Colak

Abstract

Introduction:

Determining the factors affecting hemoglobin A1c (HbA1c) levels may help better interpretation of HbA1c values. In this study, we investigated if insulin resistance is a significant parameter contributing to the variability of HbA1c values.

Methods:

We retrospectively analyzed serum fasting glucose, fasting insulin, 2 h glucose and HbA1c records of 18–85 years aged outpatients who underwent a 75 g oral glucose tolerance test (OGTT) in our hospital during the period January 2010–May 2014. Homeostasis model assessment of insulin resistance (HOMA-IR) ≥2.5 was defined as insulin resistant.

Results:

Insulin resistant subjects with normal glucose tolerance had significantly higher HbA1c and fasting glucose levels compared to insulin sensitive subjects with normal glucose tolerance (p=0.002, p<0.001, respectively). Similarly, insulin resistant subjects with pre-diabetes had significantly higher HbA1c and 2-h glucose levels compared to insulin sensitive subjects with pre-diabetes (p=0.016, p=0.013, respectively). Regression analysis showed that HOMA-IR(log) is associated with HbA1c levels independent of fasting and 2h glucose concentrations (p<0.001). Age was the variable with highest standardized β coefficient in regression model.

Conclusion:

Our data showed that HOMA-IR is associated with glycated hemoglobin values independent of glycemic status and the effect of age on HbA1c values should not be ignored in non-diabetic subjects.

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Turkish Journal of Biochemistry (TJB), official journal of Turkish Biochemical Society, is issued electronically every 2 months. The main aim of the journal is to support the research and publishing culture by ensuring that every published manuscript has an added value and thus providing international acceptance of the “readability” of the manuscripts published in the journal.

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