NT-proBNP levels in β-thalassemia major patients without cardiac hemosiderosis

Ayşegül Uğur Kurtoğlu 1 , 2 , Volkan Karakuş 3 , Erdal Kurtoğlu 4 ,  und Selen Bozkurt 5
  • 1 Antalya Education and Research Hospital, Department of Biochemistry, Antalya 07050, Turkey
  • 2 Varlık Mah. Antalya Eğitim ve Araştırma Hastanesi Merkez Laboratuvarı, Turkey
  • 3 Education and Research Hospital, Department of Hematology, Sıtkı Koçman University, Muğla, Turkey
  • 4 Antalya Education and Research Hospital, Department of Hematology, Antalya, Turkey
  • 5 Faculty of Medicine, Department of Biostatistics Medical Informatics, Akdeniz University, Antalya, Turkey
Ayşegül Uğur Kurtoğlu, Volkan Karakuş, Erdal Kurtoğlu und Selen Bozkurt

Abstract

Introduction:

Heart failure due to hemosiderosis is frequent in beta-thalassemia major (β-TM) patients. Magnetic resonance imaging (MRI) is used in the early detection of heart failure. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a very sensitive marker in the diagnosis of heart failure. In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2*>20 msn), in early identification of cardiac failure.

Methods:

NT-proBNP levels of 31 patients, who have T2*>20 ms, and of 25 healthy population were measured by chemoluminescence method.

Results:

NT-proBNP levels were not different in thalassemic patients [median: 33 (IQR: 28–94) pg/mL] compared to control group [median: 41 (IQR: 28–59) pg/mL]. We found that NT-proBNP level was above cut-off value in six patients.

Conclusion:

NT-proBNP is a cheaper, reachable, and noninvasive method compared to MRI technique, it can be easily used in monthly controls. Detection of high NT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NT-pro-BNP is a more sensitive marker in early detection of cardiac failure.

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Turkish Journal of Biochemistry (TJB), official journal of Turkish Biochemical Society, is issued electronically every 2 months. The main aim of the journal is to support the research and publishing culture by ensuring that every published manuscript has an added value and thus providing international acceptance of the “readability” of the manuscripts published in the journal.

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