Comparative studies of the biological activities of selected herbal extracts and phenolic compounds isolated from Rosa gallica

Atsumi Shimada
  • Corresponding author
  • Division of Food and Nutrition, Nakamura Gakuen University Junior College, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan
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, Hiroshi Ueno
  • Department of Medical Technology, Kawasaki University of Medical Welfare, Okayama, 701-0193, Japan
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, Masanori Inagaki
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yasuda Women’s University, Hiroshima, 731-0153, Japan
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and Hitoshi Yoshimitsu
  • Department of Pharmaceutical Sciences, Faculty of Pharmacy, Sojo University, Kumamoto, 860-0082, Japan
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This study aimed to compare the biological activities of 35 herbal hydroethanolic extracts and select high potential extract, which showed antioxidative activity and inhibitory activities of α-glucosidase, lipase, and hyaluronidase, and to investigate the isolation, structural elucidation, and biological activities of five phenolic compounds from the selected extracts of Rosa gallica. On the basis of one-dimensional nuclear magnetic resonance together with the comparison with the literature values, the phenolic compounds were identified as methyl gallate (1), kaempferol-3-O-arabinofuranoside (2), multinoside A acetate (3), kaempferol (4), and quercetin (5), respectively. The results suggest that the extracts from R. gallica show the strongest biological activities in 35 herbal extracts and that 1, 4, and 5 among the five isolated compounds from rose extracts are effective in promoting antioxidative and enzymatic inhibitory activities.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.