Acute toxicity of Potentilla anserina L. extract in mice

Dul Dram 1 , Cui-Zhu Zhao 2 , Qin-Ge Ma 2 , Jun-Wei He 2 , Jia-Jie Duo 1 , Zhen Dan 1  and Rong-Rui Wei 2
  • 1 Tibetan Medicine Department, University of Tibetan Medicine, Lasa 850000, PR China
  • 2 Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China
Dul Dram
  • Corresponding author
  • Tibetan Medicine Department, University of Tibetan Medicine, Lasa 850000, PR China
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, Cui-Zhu Zhao
  • Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China
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, Qin-Ge Ma
  • Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China
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, Jun-Wei He
  • Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China
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, Jia-Jie Duo
  • Tibetan Medicine Department, University of Tibetan Medicine, Lasa 850000, PR China
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, Zhen Dan
  • Tibetan Medicine Department, University of Tibetan Medicine, Lasa 850000, PR China
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and Rong-Rui Wei
  • Corresponding author
  • Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China
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Abstract

Potentilla anserina L. is not only a medicinal plant, but also a traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Forty Kunming mice were randomly divided into two groups: control group and P. anserina L. extract group. Using the maximum dosage method, the P. anserina L. extract group was given the maximum dose within 12 h, equivalent to 345.6 g/kg crude drug. The control group was given distilled water. After administration, toxicity symptoms of mice were observed, body weight and food intake were recorded. After 14 days, blood was collected to measure biochemical parameters, autopsy was carried out to observe the changes of organs, and the vital organs were separated, weighed, and preserved for histopathological examination. The results showed that P. anserina L. extract group had no toxic symptoms. The activity, weight, and diet of mice were normal, and no abnormality was found in organ index, renal function, liver function, anatomical observation, and histopathological examination. Therefore, the maximum oral dosage (345.6 g/kg) of P. anserina L. was good safety. This study indicated that P. anserina L. had a large safety range and the clinical application was safe.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.

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