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for my three energetic boys, Ethan, Gavin, and Jacob, whose early deter- mination to make the world a better place makes me a very proud father. David A. Ansell. I am grateful for the love and support of my wife, Dr. Paula Grabler, my two children, Jonah and Leah Ansell, their spouses, and my grandson, Rafael. I am also grateful for my many friends and col- leagues at Rush University Medical Center and across the United States who have provided me guidance and insight. As a group, we are humbled by the creativity and sophistication of the authors of the

consumers from inevitable drug risks such as addiction. True, protections were almost always insufficient— this is why white markets were in crisis for so much of the past 150 years. But the crises also provoked political creativity, leading reformers to build stronger and more effective regulations. Flawed as they were, these white market reforms were the closest approximations of successful drug policy that America has ever seen. Given the disastrous track record of the nation’s drug wars, they are models that merit serious attention. The mixed track record of

to this book. Kevin Gotkin and Aaron Shapiro helped me as I was just diving into the work; Rachel Stone- cipher, Sun- Ha Hong, and Yoel Roth saw it through to its completion with creativity, diligence, and brilliance. They thought of much that I would not have, and know much that I do not, and they shared their ideas and their expertise tirelessly and generously. They, along with Piotr Szpunar, Tara Liss- Mariño, Brooke Duff y, Steven Schrag, Jonathan Pace, and Megan Genovese, have listened extensively and patiently, helping me work out and improve my

many. Contemporary Mining as Context of iThemba’s Work Today, mining continues to dominate the chemical industry in South Af- rica. In this context, chemists in all fi elds are aware of the mining industry as a possible career option. For those trained in the area of organic syn- thesis, this can make the mining industry seem like a site of a sector brain drain. For many, mining work is an undesirable option, failing to exploit In the Shadows of the Dynamite Factory / 55 their creativity and specialized skills. Synthetic chemists in South Africa can choose

Pages 58–61 Stephanson, The Yard of Wit: Male Creativity and Sexuality, 1650– 1750 (Philadelphia: University of Pennsylvania Press, 2004), 207– 10, 250n103. 35. Anon., Roxburghe Ballads (London, 1774), 1 : 28– 29; Lisa Jardine, Still Harping on Daugh- ters: Women and Drama in the Age of Shakespeare (Brighton: Harvester Press, 1983), 123; Fletcher, Gender, Sex and Subordination, 5– 11; Kenneth A. Lockridge, On the Sources of Patriarchal Rage: The Commonplace Books of William Byrd and Thomas Jefferson and the Gendering of Power in the Eighteenth Century (New York

, 2017. https:// www .mmv .org/ newsroom/ press - releases/ uct - h3d - mmv - and - international - partners - identify - second - potent - antimalarial. Mika, Marissa. “Fifty Years of Creativity, Crisis, and Cancer in Uganda.” Canadian Journal of African Studies / Revue canadienne des études africaines 50, no. 3 (2016): 395– 413. Milne, Richard. “Pharmaceutical Prospects: Biopharming and the Geography of Techno- logical Expectations.” Social Studies of Science 42, no. 2 (2012): 290– 306. Milner, Katie M., and Nancy Baym. “The Selfi e of the Year of the Selfi e

more burdensome, spawning both political critique and individual creativity.19 In the case of tuberculosis, laboratories, X- ray machines, technicians, and clinics were all necessary to create and en- hance the biological effi cacy of antibiotics. In the case of HIV, labora- tories, rapid test kits, clinics, and CD4 machines (notoriously prone to breakdowns) are all needed to transform the politics of access to ARVs into the extension of life. With cancer, the situation grows ever more complex. In other words, Batswana are learning rapidly about the power of

to oversee the never- ending creativity of pharmaceutical marketing. In the case of Dilaudid, for example, the FBN continued to monitor advertisements for years, demanding line- by- line and even word- by- word revisions when errant claims crept in, as they seemed to do with some regularity.36 The Bureau also performed a sort of ad hoc form of postmarketing surveillance— another regulatory innovation— by keeping close tabs on sales and instructing district chiefs to look for and compile cases of addiction to Dilaudid along with several other “unusual drugs

decadents from Baudelaire to Huysmans perversely embraced impotence as a metaphor for both sensitivity and cultural exhaustion. Neurasthenia itself was not always Neurasthenia, Decadence, and Nineteenth-Century Manhood 119 viewed completely negatively; some saw it as a price paid for creativity and refi nement. Impotence likewise came to be viewed ambivalently. In the last decades of the nineteenth century the themes of real and metaphorical im- potence, along with nervousness and irritability were intertwined by the masters of decadent art. In England and America

. Lack of reliable availability of electricity is a signifi cant barrier to pharmaceutical manufacture in Nigeria, for example, as described by Kristin Peterson, Speculative Markets: Drug Circuits and Derivative Life in Nigeria (Durham, NC: Duke University Press, 2014), 123. 8. Marissa Mika, “Fifty Years of Creativity, Crisis, and Cancer in Uganda,” Canadian Journal of African Studies / Revue canadienne des études africaines 50, no. 3 (2016): 397. 9. Ann Laura Stoler, “‘The Rot Remains’: From Ruins to Ruination,” in Imperial Debris: On Ruins and Ruination, ed. Ann