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Editor-in-Chief – Bernhard Brüne

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Prof. Dr. rer. nat. Bernhard Brüne

Prof. Dr. rer. nat. Bernhard Brüne

Vita & Research interests

Bernhard Brüne studied Biochemistry at the University of Tübingen, Germany and earned his PhD at the University of Konstanz, Germany. Two Postdoc periods, one at Burroughs Wellcome, Division of Cell Biology, Research Triangle Park, NC, USA, and a second one at the Karolinska Institute, Department of Toxicology, Stockholm, Sweden followed. In 1995 he became Professor of Experimental Medicine and Head of a Clinical Research Group, University of Erlangen-Nürnberg, Germany and moved to the University of Kaiserslautern in 2001 to serve as Head of Department of Cell Biology. In 2004 he took up the position as Head of Department of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Germany. Following job offers to Sweden, Norway, Denmark and Australia were declined. At the Goethe-University he is speaker of the Collaborative Research Center 815 ‘Redox-Regulation’ and was elected Dean of curriculum in 2013. Since 2012 he acts as Editor-in-Chief for Biological Chemistry.

Research interests:

  • Hypoxia and the role of HIF’s during inflammation and tumor development
  • Lipid-signaling during the onset and resolution of inflammation
  • Polarization of macrophages in pathologies such as cancer or psoriasis
  • Gene regulatory control mechanism during stress

Personal perspective on Biological Chemistry:

It is a pleasure and honor of serving a biomedical-orientated journal founded in 1877 as the ‘Journal of Physiological Chemistry’ that published landmark papers in the field of Physiological Chemistry.

Keeping with the tradition, while at the same time developing a journal into new areas of the reader’s interests, guaranteeing a fair and timely review process and helping to position a journal scientifically and administratively towards the demands of the researchers is challenging and rewarding.

The close interaction with the Executive Editors, the Editorial Board members and the Editorial Office is fruitful and we are looking forward to seeing good papers being submitted, follow their improvement during the review process with the helpful comments of our referees, and finally have these manuscripts being published in Biological Chemistry.



Many excellent papers need consideration and deserve to be mentioned. Thus, the choice is a very personal one, reflecting my scientific interests:

Mapping the non-standardized biases of ribosome profiling

Alexander Bartholomäus / Cristian Del Campo / Zoya Ignatova
DOI: 10.1515/hsz-2015-0197

“This review addresses an emerging methodological aspect of massively parallel amplification of ribosome protected fragments and next-generation sequencing to monitor translation in vivo with codon resolution. For new techniques it is fundamental to know differences between experimental set-ups, current protocols, and potential pitfalls. This work provides an excellent overview, helping to make proper use of these emerging technologies.”

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

Noemí Esteras / Albena T. Dinkova-Kostova / Andrey Y. Abramov
DOI: 10.1515/hsz-2015-0295

“This work highlights the recently recognized ability of Nrf2 to regulate intermediary metabolism and mitochondrial function. These aspects are important to increase our understanding towards neurodegenerative conditions and chronic inflammation, expanding our knowledge on an important cytoprotective activity of this transcription factor.“

Regulation of necroptosis signaling and cell death by reactive oxygen species

Simone Fulda
DOI: 10.1515/hsz-2016-0102

“This paper explores roles of oxygen species in affecting necroptosis, a regulated form of necrotic cell death. The identification of new targets suggests mechanisms how redox-signaling works at the molecular level, i.e. the necrosome complex. This may open new perspectives to interfere with this from of programmed cell death under pathophysiological conditions.“

Annexin A1: shifting the balance towards resolution and repair

Giovanna Leoni / Asma Nusrat
DOI: 10.1515/hsz-2016-0180

“Knowing annexins for a long time there is now accumulating evidence supporting an important role of annexin A1 in facilitating resolution of inflammation and wound repair. Of particular interest is the role of annexin A1 in monocyte/macrophage migration, recruitment, efferocytosis, and polarization.”

IL-1 family cytokines in cancer immunity – a matter of life and death

Javier Mora / Andreas Weigert
DOI: 10.1515/hsz-2016-0215

“IL-1 family members, especially new members such as IL-38, are known to modulate the tumor microenvironment. We learn that apoptotic cell-dependent immune regulation requires IL-38 processing and secretion, which might be relevant during resolution of inflammation, autoimmunity, and cancer.”