Open Medicine: Topical Issue on Ophthalmology
Qian Liu, Tianjin Medical University General Hospital, China
Ocular trauma is a serious problem for our health system and economy. Many mechanical, physical and chemical factors can direct effect on the eye, damage to the structure and function of the eye, causing visual impairment even blindness.
In general, some injuries such as the more serious types of ocular trauma—ruptured globes and corneal lacerations requiring surgical reconstruction—are less frequently seen by most ophthalmologists. While some injuries lead to complications such as traumatic glaucoma, traumatic cataract, retinal degeneration, loss and damage of the various retinal cell types, etc., lead to impaired vision present a major medical and public health problem.
Traumatic optic nerve injury and glaucoma are among the leading causes of incurable vision loss across the world. After injury, retinal ganglion cell (RGC) axons usually fail to regrow and die, leading to disrupt the normal transmission of nerve signals and irreversible loss of vision. Various kinds of cells and factors possess the ability to support the process of axon regeneration for RGCs.
New approach involving cell transplantation, including use of stem cells, to restore RGC that irreversible injured, are very promising. However, the therapeutic technology is still challenging.
Here, we invite surgeons with extensive experience discuss their approaches to managing these kinds of trauma. Also all aspects of ocular trauma, clinical surgeries and therapies including regeneration, the stem cell treatments are encouraged.