Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 381, Issue 9-10


Selenium in Biology: Facts and Medical Perspectives

Josef Köhrle / Regina Brigelius-Flohé / August Böck / Roland Gärtner / Ortwin Meyer / Leopold Flohé
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/BC.2000.107


Several decades after the discovery of selenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21st proteinogenic amino acid, selenocysteine, have been identified, partially characterized or cloned from several species. Many of these proteins are involved in redox reactions with selenocysteine acting as an essential component of the catalytic cycle. Enzyme activities have been assigned to the glutathione peroxidase family, to the thioredoxin reductases, which were recently identified as selenoproteins, to the iodothyronine deiodinases, which metabolize thyroid hormones, and to the selenophosphate synthetase 2, which is involved in selenoprotein biosynthesis. Prokaryotic selenoproteins catalyze redox reactions and formation of selenoethers in (stress-induced) metabolism and energy production of E. coli, of the clostridial cluster XI and of other prokaryotes. Apart from the specific and complex biosynthesis of selenocysteine, selenium also reversibly binds to proteins, is incorporated into selenomethionine in bacteria, yeast and higher plants, or posttranslationally modifies a catalytically essential cysteine residue of CO dehydrogenase. Expression of individual eukaryotic selenoproteins exhibits high tissue specificity, depends on selenium availability, in some cases is regulated by hormones, and if impaired contributes to several pathological conditions. Disturbance of selenoprotein expression or function is associated with deficiency syndromes (Keshan and Kashin-Beck disease), might contribute to tumorigenesis and atherosclerosis, is altered in several bacterial and viral infections, and leads to infertility in male rodents.

About the article

Published Online: 2005-07-05

Published in Print: 2000-09-13

Citation Information: Biological Chemistry, Volume 381, Issue 9-10, Pages 849–864, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2000.107.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Apramita Chand and Himansu S. Biswal
Journal of the Indian Institute of Science, 2019
N. Iu. Beliaeva, A. I. Ashenbrenner, Iu. A. Chekunkova, and Iu. A. Khaperskiy
Bulletin of NSAU (Novosibirsk State Agrarian University), 2019, Number 3, Page 74
SJ Hendriks and RA Laven
New Zealand Veterinary Journal, 2019, Page 1
Mahmoud A. O. Dawood, Shunsuke Koshio, Amr I. Zaineldin, Hien Van Doan, Hamada A. Ahmed, Mabrouk Elsabagh, and Mohamed M. Abdel-Daim
Environmental Science and Pollution Research, 2019
M. M. Stenchuk, L. B. Chaban, and M. V. Gonchar
Biopolymers and Cell, 2006, Volume 22, Number 1, Page 3
Nicholas V.C. Ralston, J. John Kaneko, and Laura J. Raymond
Journal of Trace Elements in Medicine and Biology, 2019, Volume 55, Page 50
Ruslan Rafikov, Joel James, Nolan McClain, Stevan P. Tofovic, and Olga Rafikova
Antioxidants, 2019, Volume 8, Number 5, Page 135
S. Salman, A. Khol-Parisini, H. Schafft, M. Lahrssen-Wiederholt, H. W. Hulan, D. Dinse, and J. Zentek
Animal Health Research Reviews, 2009, Volume 10, Number 1, Page 21
Roberto Negro, Gabriele Greco, Tiziana Mangieri, Antonio Pezzarossa, Davide Dazzi, and Haslinda Hassan
The Journal of Clinical Endocrinology & Metabolism, 2007, Volume 92, Number 4, Page 1263
J. Köhrle, F. Jakob, B. Contempré, and J. E. Dumont
Endocrine Reviews, 2005, Volume 26, Number 7, Page 944
Нгуен Тхи Минь Кхань, Nguyen Thi Minh Khanh, Нгуен Тхи Чанг, Nguyen Thi Trang, Ле Дык Мань, Le Duc Manh, Ле Хонг Куанг, and Le Hong Quang
Food Processing: Techniques and Technology, 2019, Volume 48, Number 4, Page 114
Bernd Moosmann and Christian Behl
Trends in Cardiovascular Medicine, 2004, Volume 14, Number 7, Page 273
World's Poultry Science Journal, 2017, Volume 73, Number 1, Page 175
Ioannis Kyrgios, Styliani Giza, Eleni P. Kotanidou, Angeliki Kleisarchaki, Vasiliki Rengina Tsinopoulou, Anastasia Papadopoulou, Anthi-Marina Markantonatou, Eleni Kanellidou, Anastasia Giannakou, and Assimina Galli-Tsinopoulou
Journal of Clinical Pharmacy and Therapeutics, 2018
Nicholas VC Ralston
Free Radical Biology and Medicine, 2018
Sadegh Saffari, Saeed Keyvanshokooh, Mohammad Zakeri, Seyed Ali Johari, Hossein Pasha-Zanoosi, and Mansour Torfi Mozanzadeh
Fish Physiology and Biochemistry, 2018
Kifayat Ullah KHAN, Amina ZUBERI, Samina NAZIR, João Batista Kochenborger FERNANDES, Zeenat JAMIL, and Huda SARWAR
TURKISH JOURNAL OF ZOOLOGY, 2016, Volume 40, Page 704
Ulrich Schweizer, Lutz Schomburg, and Nicolai E. Savaskan
The Journal of Nutrition, 2004, Volume 134, Number 4, Page 707
Kifayat Ullah Khan, Amina Zuberi, João Batista Kochenborger Fernandes, Imdad Ullah, and Huda Sarwar
Fish Physiology and Biochemistry, 2017
Gary E. Olson, Virginia P. Winfrey, Subir K. NagDas, Kristina E. Hill, and Raymond F. Burk
Journal of Biological Chemistry, 2007, Volume 282, Number 16, Page 12290
Stephan Gromer and Jürgen H. Gross
Journal of Biological Chemistry, 2002, Volume 277, Number 12, Page 9701
伟 刘
Open Journal of Nature Science, 2017, Volume 05, Number 02, Page 126
Mahdi Naderi, Saeed Keyvanshokooh, Amir Parviz Salati, and Alireza Ghaedi
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2017, Volume 22, Page 10
Katherine R. S. Connelly, Calum Stevenson, Holger Kneuper, and Frank Sargent
Microbiology, 2016, Volume 162, Number 12, Page 2136
Ilham Ilham, Muhammad Abu Bakar Siddik, and Ravi Fotedar
Biological Trace Element Research, 2016, Volume 174, Number 2, Page 436
Hanaa H. Ahmed, Mohamed Diaa Abd El-Maksoud, Ahmed E. Abdel Moneim, and Hadeer A. Aglan
Biological Trace Element Research, 2017, Volume 177, Number 2, Page 267
Claudia Swart and Norbert Jakubowski
J. Anal. At. Spectrom., 2016, Volume 31, Number 9, Page 1756
H Khalili, A Soudbakhsh, M Hajiabdolbaghi, S Dashti-Khavidaki, A Poorzare, AA Saeedi, and R Sharififar
BMC Infectious Diseases, 2008, Volume 8, Number 1
R Safaralizadeh, GA Kardar, Z Pourpak, M Moin, A Zare, and S Teimourian
Nutrition Journal, 2005, Volume 4, Number 1
Hans J. Reich and Robert J. Hondal
ACS Chemical Biology, 2016, Volume 11, Number 4, Page 821
Charlotte Daun, Thomas Lundh, Gunilla Önning, and Björn Åkesson
J. Anal. At. Spectrom., 2004, Volume 19, Number 1, Page 129
V. Díaz Huerta, J. Szpunar, R. Lobinski, M. L. Fernández Sánchez, and A. Sanz-Medel
J. Anal. At. Spectrom., 2003, Volume 18, Number 12, Page 1471
Marc Birringer, Sandra Pilawa, and Leopold Flohé
Nat. Prod. Rep., 2002, Volume 19, Number 6, Page 693
Regina Brigelius-Flohé and Antje Banning
Free Radical Research, 2006, Volume 40, Number 8, Page 775
X Liu, J Piao, M Li, Y Zhang, C Yun, C Yang, and X Yang
European Journal of Clinical Nutrition, 2016, Volume 70, Number 3, Page 405
K.M. Gowdy, F.W. Edens, and K.Z. Mahmoud
International Journal of Poultry Science, 2015, Volume 14, Number 7, Page 376
Akira Andoh, Masaki Hirashima, Hiroaki Maeda, Kazunori Hata, Osamu Inatomi, Tomoyuki Tsujikawa, Masaya Sasaki, Kazuhiko Takahashi, and Yoshihide Fujiyama
Nutrition, 2005, Volume 21, Number 5, Page 574
T. Klapec, M.L. Mandić, J. Grgić, Lj. Primorac, A. Perl, and V. Krstanović
Food Chemistry, 2004, Volume 85, Number 3, Page 445
A. Pfohl-Leszkowicz, K. Hadjeba-Medjdoub, N. Ballet, J. Schrickx, and J. Fink-Gremmels
Food Additives & Contaminants: Part A, 2015, Volume 32, Number 4, Page 604
I. Placha, J. Takacova, M. Ryzner, K. Cobanova, A. Laukova, V. Strompfova, K. Venglovska, and S. Faix
British Poultry Science, 2014, Volume 55, Number 1, Page 105
V. F H Brauer, U. Schweizer, J. Kohrle, and R. Paschke
European Journal of Endocrinology, 2006, Volume 155, Number 6, Page 807
Umesh Kapil, Ajeet Singh Bhadoria, and Neha Sareen
Biological Trace Element Research, 2013, Volume 154, Number 2, Page 167
Mehul Jariwala, S. Suvarna, G. Kiran Kumar, Alpa Amin, and A. C. Udas
Indian Journal of Clinical Biochemistry, 2014, Volume 29, Number 2, Page 181
B. Navia, R. M. Ortega, J. M. Perea, A. Aparicio, A. M. López-Sobaler, and E. Rodríguez-Rodríguez
Journal of Human Nutrition and Dietetics, 2014, Volume 27, Page 239
Qian Wang, Chunxiang Zhang, Youshe Ren, Wenbin Yue, Liguang Shi, and Fulin Lei
Journal of Animal and Veterinary Advances, 2012, Volume 11, Number 16, Page 2898
K Y Wang, C Z Peng, J L Huang, Y D Huang, M C Jin, and Y Geng
Journal of Fish Diseases, 2013, Volume 36, Number 7, Page 609
Masoud Mehrpour, Anahita Kyani, Mohsen Tafazzoli, Fariba Fathi, and Mohammad-Taghi Joghataie
Magnetic Resonance in Chemistry, 2012, Page n/a
Beatrice Cobucci-Ponzano, Mosè Rossi, and Marco Moracci
Extremophiles, 2012, Volume 16, Number 6, Page 793
Mahima ., Amit Kumar Verma, Amit Kumar, Anu Rahal, Vinod Kumar, and Debashis Roy
Pakistan Journal of Biological Sciences, 2012, Volume 15, Number 9, Page 418
So Hee Nam, Seung Eun Jung, Yoen Kyung Lee, Ji Eun Kim, Eon Pil Lee, Hae Wook Choi, Hong Sung Kim, Jae Ho Lee, Young Jin Jung, Chung Yeol Lee, Hong Ju Son, Hyun Woong Lee, Jung Sik Cho, Byeong-Cheol Kang, and Dae Youn Hwang
Laboratory Animal Research, 2010, Volume 26, Number 1, Page 37
Sheldon R. Pinnell
Journal of the American Academy of Dermatology, 2003, Volume 48, Number 1, Page 1
Shelli R. Mellegaard-Waetzig, Chao Wang, and Jon A. Tunge
Tetrahedron, 2006, Volume 62, Number 30, Page 7191
Huijuan Liu, Li Yin, Philip G. Board, Xiao Han, Zhenlin Fan, Jingqi Fang, Zeyuan Lu, Yini Zhang, and Jingyan Wei
Protein Expression and Purification, 2012, Volume 84, Number 1, Page 59
Jose G. Dorea
Journal of Trace Elements in Medicine and Biology, 2002, Volume 16, Number 4, Page 207
A.C. Pappas, E. Zoidis, P.F. Surai, and G. Zervas
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008, Volume 151, Number 4, Page 361
Yu Chen and Wolfgang Maret
European Journal of Biochemistry, 2001, Volume 268, Number 11, Page 3346
XiuAn Zhan, Min Wang, RuQian Zhao, WeiFeng Li, and ZiRong Xu
Animal Feed Science and Technology, 2007, Volume 132, Number 3-4, Page 202
K.W. Riley, D.H. French, N.A. Lambropoulos, O.P. Farrell, R.A. Wood, and F.E. Huggins
International Journal of Coal Geology, 2007, Volume 72, Number 2, Page 72
Eleftherios Ferentinos, Alexandros B. Tsoupras, Maria Roulia, Spyros D. Chatziefthimiou, Constantinos A. Demopoulos, and Panayotis Kyritsis
Inorganica Chimica Acta, 2011, Volume 378, Number 1, Page 102
Yao Zhu, Yongjun Chen, Yongjian Liu, Huijun Yang, Guiying Liang, and Lixia Tian
Aquaculture Research, 2012, Volume 43, Number 11, Page 1660
YongXia Wang, XiuAn Zhan, XiWen Zhang, RuJuan Wu, and Dong Yuan
Biological Trace Element Research, 2011, Volume 143, Number 1, Page 261
Yan Ge, Zhenhui Qi, Ying Wang, Xiaoman Liu, Jing Li, Jiayun Xu, Junqiu Liu, and Jiacong Shen
The International Journal of Biochemistry & Cell Biology, 2009, Volume 41, Number 4, Page 900
Claudia Swart, Olaf Rienitz, and Detlef Schiel
Talanta, 2011, Volume 83, Number 5, Page 1544
Zhihua Jiang, Elias S.J. Arnér, Ying Mu, Linda Johansson, Jinming Shi, Siqi Zhao, Shujun Liu, Ruiying Wang, Tianzhu Zhang, Ganglin Yan, Junqiu Liu, Jiacong Shen, and Guimin Luo
Biochemical and Biophysical Research Communications, 2004, Volume 321, Number 1, Page 94
Gil Hardy and Ines Hardy
Nutrition, 2004, Volume 20, Number 6, Page 590
Gil Hardy, Ana Maria Menendez, and William Manzanares
Nutrition, 2009, Volume 25, Number 11-12, Page 1073
Antonella Roveri, Maria Pia Vitale, Elena Serain, Mattia Zaccarin, Pierluigi Mauri, Dario Di Silvestre, Antonella De Palma, Massimo Gion, Stefano Toppo, Matilde Maiorino, and Fulvio Ursini
Journal of Chromatography B, 2008, Volume 865, Number 1-2, Page 63
Nicholas V.C. Ralston, Carla R. Ralston, J. Lloyd Blackwell, and Laura J. Raymond
NeuroToxicology, 2008, Volume 29, Number 5, Page 802
Tilmann Stock and Michael Rother
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, Volume 1790, Number 11, Page 1520
Nicholas V.C. Ralston and Laura J. Raymond
Toxicology, 2010, Volume 278, Number 1, Page 112
Qin Liu, Xiaoyong Wang, Xiaoliang Yang, Xiao Liang, and Zijian Guo
Journal of Inorganic Biochemistry, 2010, Volume 104, Number 11, Page 1178
Roger C. Prince, Jürgen Gailer, Diane E. Gunson, Raymond J. Turner, Graham N. George, and Ingrid J. Pickering
Journal of Inorganic Biochemistry, 2007, Volume 101, Number 11-12, Page 1891
Christine A. Zuberbuehler, Ruth E. Messikommer, Myrtha M. Arnold, Rhea S. Forrer, and Caspar Wenk
Physiology & Behavior, 2006, Volume 87, Number 2, Page 430
Molouk Hadjibabaie, Masoud Iravani, Ahmad Reza Shamshiri, Zahra Zaker, Asadollah Mousavi, Kamran Alimoghaddam, Babak Bahar, Ebrahim Kalantar, and Ardeshir Ghavamzadeh
Nutrition and Cancer, 2008, Volume 60, Number 6, Page 837
Josef Köhrle and Roland Gärtner
Best Practice & Research Clinical Endocrinology & Metabolism, 2009, Volume 23, Number 6, Page 815
Elwira Przybylik-Mazurek, Paweł Zagrodzki, Sylwia Kuźniarz-Rymarz, and Alicja Hubalewska-Dydejczyk
Biological Trace Element Research, 2011, Volume 141, Number 1-3, Page 65
Ulrich Schweizer, Anja U Bräuer, Josef Köhrle, Robert Nitsch, and Nicolai E Savaskan
Brain Research Reviews, 2004, Volume 45, Number 3, Page 164
Jean Nève
Current Opinion in Clinical Nutrition and Metabolic Care, 2002, Volume 5, Number 6, Page 659
Josef Köhrle
Thyroid, 2005, Volume 15, Number 8, Page 841
Susan J. Fairweather-Tait, Yongping Bao, Martin R. Broadley, Rachel Collings, Dianne Ford, John E. Hesketh, and Rachel Hurst
Antioxidants & Redox Signaling, 2011, Volume 14, Number 7, Page 1337
Georgios Karanikas, Matthias Schuetz, Sylvester Kontur, Heying Duan, Spyridoula Kommata, Robert Schoen, Anna Antoni, Kurt Kletter, Robert Dudczak, and Martin Willheim
Thyroid, 2008, Volume 18, Number 1, Page 7
Regina Brigelius-Flohé, Antje Banning, and Kerstin Schnurr
Antioxidants & Redox Signaling, 2003, Volume 5, Number 2, Page 205
Christian Murr, Heribert Talasz, Erika Artner-Dworzak, Katharina Schroecksnadel, Michael Fiegl, Dietmar Fuchs, and Hubert A. Denz
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 9
John E. Hesketh and Stéphane Villette
Proceedings of the Nutrition Society, 2002, Volume 61, Number 04, Page 405
Lutz Schomburg, Cornelia Riese, Kostja Renko, and Ulrich Schweizer
Biological Chemistry, 2007, Volume 388, Number 10
Dana Kotyzová, Pavla Černá, Ladislav Lešetický, and Vladislav Eybl
Biological Trace Element Research, 2010, Volume 136, Number 3, Page 287
Holger Blessing, Silke Kraus, Philipp Heindl, Wojciech Bal, and Andrea Hartwig
European Journal of Biochemistry, 2004, Volume 271, Number 15, Page 3190
Elżbieta Lipiec, Grzegorz Siara, Katarzyna Bierla, Laurent Ouerdane, and Joanna Szpunar
Analytical and Bioanalytical Chemistry, 2010, Volume 397, Number 2, Page 731
Young-Jae Kim, Oyunbileg Galindev, Jun Han Sei, Su-Mi Bae, Hosub Im, Lanying Wen, Young Rok Seo, and Woong Shick Ahn
Biological Trace Element Research, 2009, Volume 131, Number 2, Page 103
Matthias WA Angstwurm and Roland Gaertner
Current Opinion in Clinical Nutrition and Metabolic Care, 2006, Volume 9, Number 3, Page 233
Jose G. Dorea
British Journal of Nutrition, 2002, Volume 88, Number 05, Page 443
John H. Beattie and In-Sook Kwun
British Journal of Nutrition, 2004, Volume 91, Number 02, Page 177
Zoyne Pedrero, Yolanda Madrid, Carmen Cámara, Edward Schram, Joop B. Luten, Ingo Feldmann, Larissa Waentig, Heiko Hayen, and Norbert Jakubowski
Journal of Analytical Atomic Spectrometry, 2009, Volume 24, Number 6, Page 775
Nicholas V. C. Ralston
EcoHealth, 2008, Volume 5, Number 4, Page 442
Alejandro Fernández-Martínez and Laurent Charlet
Reviews in Environmental Science and Bio/Technology, 2009, Volume 8, Number 1, Page 81
G.A. Milias, T. Nomikos, E. Fragopoulou, S. Athanasopoulos, and S. Antonopoulou
BioFactors, 2006, Volume 26, Number 3, Page 161
Reza Safaralizadeh, Mahshid Sirjani, Zahra Pourpak, Gholamali Kardar, Shahram Teimourian, Sedigheh Shams, Zahra Namdar, Anoushiravan Kazemnejad, and Mostafa Moin
BioFactors, 2007, Volume 31, Number 2, Page 127
Roland Gärtner and Barbara C. H. Gasnier
BioFactors, 2003, Volume 19, Number 3-4, Page 165
J. P. Schreckenbach and H.-L. Graf
Journal of Materials Science: Materials in Medicine, 2008, Volume 19, Number 1, Page 233
G A Jacobson, Y C Tong, A T Townsend, A M Featherstone, M Ball, I K Robertson, and G M Peterson
European Journal of Clinical Nutrition, 2007, Volume 61, Number 9, Page 1057
Daeyoun Hwang, Sujin Seo, Yongkyu Kim, Chuelkyu Kim, Sunbo Shim, Seungwan Jee, Suhae Lee, Mikyong Jang, Minsun Kim, Suyoun Yim, Sang-Koo Lee, Byeongcheol Kang, Insurk Jang, and Jungsik Cho
Journal of Biosciences, 2007, Volume 32, Number 4, Page 723
Óscar Muñiz-Naveiro, Raquel Domínguez-González, Adela Bermejo-Barrera, Pilar Bermejo-Barrera, José A. Cocho, and José M. Fraga
Analytical and Bioanalytical Chemistry, 2006, Volume 385, Number 1, Page 189
Melenie Alonis, Sheldon Pinnell, and William T. Self
Photodermatology, Photoimmunology & Photomedicine, 2006, Volume 22, Number 6, Page 315
Sonya Vasto, Eugenio Mocchegiani, Giuseppina Candore, Florinda Listì, Giuseppina Colonna-Romano, Domenico Lio, Marco Malavolta, Robertina Giacconi, Catia Cipriano, and Calogero Caruso
Biogerontology, 2006, Volume 7, Number 5-6, Page 315
Hyun Ju Chung, Sun Il Yoon, Sun Hye Shin, Yeon A. Koh, Su-Jae Lee, Yun-Sil Lee, and Sangwoo Bae
Journal of Cellular Physiology, 2006, Volume 209, Number 1, Page 131
Qichang Shen, Lin Fan, and Peter E. Newburger
Journal of Cellular Physiology, 2006, Volume 207, Number 3, Page 775
M. Malbe, M. Attila, and F. Atroshi
Journal of Animal Physiology and Animal Nutrition, 2006, Volume 90, Number 3-4, Page 159
Ju Hee Lee, Kee Yang Chung, Dongsik Bang, and Kwang Hoon Lee
PROTEOMICS, 2006, Volume 6, Number 4, Page 1351
Nils E. Magnusson, Agnete Larsen, Jørgen Rungby, Mogens Kruhøffer, Torben F. Ørntoft, and Meredin Stoltenberg
Cell and Tissue Research, 2005, Volume 321, Number 2, Page 195
The Journal of Eukaryotic Microbiology, 2002, Volume 49, Number 2, Page 99
Prasad P. Phadnis and G. Mugesh
Organic & Biomolecular Chemistry, 2005, Volume 3, Number 13, Page 2476
Luis Moroder
Journal of Peptide Science, 2005, Volume 11, Number 4, Page 187
�scar Mu�iz-Naveiro, Raquel Dom�nguez-Gonz�lez, Adela Bermejo-Barrera, Jos� A. Cocho, Jos� M. Fraga, and Pilar Bermejo-Barrera
Analytical and Bioanalytical Chemistry, 2005, Volume 381, Number 6, Page 1145
Nisha Gupta and Todd D. Porter
Journal of Biochemical and Molecular Toxicology, 2002, Volume 16, Number 1, Page 18

Comments (0)

Please log in or register to comment.
Log in