Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 383, Issue 3-4


Nitric Oxide and Cell Signaling Pathways in Mitochondrial-Dependent Apoptosis

C.S. Boyd / E. Cadenas
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.045


Nitric oxide, generated by endogenous nitric oxide synthases or nitric oxide donors, can promote or prevent apoptosis induced by diverse proapoptotic stimuli in cell culture models. Both mitochondrialdependent and independent apoptotic signaling pathways mediate this dichotomous cellular response to nitric oxide. The molecular mechanisms behind these effects are complex and involve a number of nitrogen oxiderelated species that are more reactive than nitric oxide itself. The local cellular environment plays a dynamic role in determining the nature and concentration of these species. Important components of the microenvironment include: the cellular redox state, glutathione, transition metals and the presence of other oxygen and nitrogencentered radicals. In particular, redoxsensitive nitrosating species are favorably generated under physiological conditions and capable of modifying multiple cell signaling pathways through reversible Snitrosation reactions. Cytochrome c release from mitochondria is an important mechanism for the activation of caspase-3 and the initiation of cell death in response to intrinsic proapoptotic stimuli, including oxidative and nitrosative stress. In turn, caspases and mitogen associated protein kinases may modulate cytochrome c release through their effects on the Bcl-2 family of proteins. This review will focus on (i) the importance of the cellular environment in determining the fate of nitric oxide and (ii) the ability of Snitrosation to regulate mitochondrialdependent apoptosis at the level of mitochondrial bioenergetics, cytochrome c release, caspases, mitogen associated protein kinases, and the Bcl-2 family of proteins.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 411–423, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.045.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Patrick B. Ampomah and Lina H. K. Lim
Apoptosis, 2019
Bo Wu, Hua Yue, Guang Hai Zhou, Yuan Yuan Zhu, Tian Hua Wu, Jin Fu Wen, Kyung Woo Cho, and Song Nan Jin
European Journal of Pharmacology, 2019, Page 172717
Yao Li, Qian Yang, Zhi-hui Shi, Min Zhou, Li Yan, Hua Li, Yan-hua Xie, and Si-wang Wang
Evidence-Based Complementary and Alternative Medicine, 2019, Volume 2019, Page 1
Mei Rao, Dongfeng Chen, Peng Zhan, and Jianqing Jiang
Biology Direct, 2019, Volume 14, Number 1
Mohsin H.K. Roshan, Amos Tambo, and Nikolai P. Pace
The Open Neurology Journal, 2016, Volume 10, Number 1, Page 42
T Gotoh, K Terada, S Oyadomari, and M Mori
Cell Death & Differentiation, 2004, Volume 11, Number 4, Page 390
Haotian Ren, Hongxu Yang, Mianjiao Xie, Yi Wen, Qian Liu, Xiaomei Li, Jun Liu, Haokun Xu, Weizhong Tang, and Meiqing Wang
Archives of Oral Biology, 2019, Volume 101, Page 108
Yin Shi, Boli Zhang, Xiaolan Feng, Fei Qu, Shuang Wang, Lijie Wu, Xiaobing Wang, Quanhong Liu, Pan Wang, and Kun Zhang
Photodiagnosis and Photodynamic Therapy, 2018
Esther M. Leise, S. C. Kempf, N. R. Durham, and D. J. Gifondorwa
Acta Biologica Hungarica, 2004, Volume 55, Number 1-4, Page 293
Andreas Leonidou, Panagiotis Lepetsos, Michalis Mintzas, Eustathios Kenanidis, George Macheras, Maria Tzetis, Michael Potoupnis, and Eleftherios Tsiridis
Expert Opinion on Therapeutic Targets, 2018, Page 1
Letícia S. Ferraz, Carolina M. Watashi, Carina Colturato-Kido, Milena T. Pelegrino, Edgar J. Paredes-Gamero, Richard B. Weller, Amedea B. Seabra, and Tiago Rodrigues
Molecular Pharmaceutics, 2018
Zhao Zhong Chong, Jing-Qiong Kang, and Kenneth Maiese
Journal of Cerebral Blood Flow & Metabolism, 2003, Volume 23, Number 3, Page 320
Ursula Rauen, Tongju Li, Iosif Ioannidis, and Herbert de Groot
American Journal of Physiology-Cell Physiology, 2007, Volume 292, Number 4, Page C1440
Rebecca Hutcheson, Russell Terry, Brenda Hutcheson, Rashmi Jadhav, Jennifer Chaplin, Erika Smith, Robert Barrington, Spencer D. Proctor, and Petra Rocic
American Journal of Physiology-Heart and Circulatory Physiology, 2015, Volume 308, Number 11, Page H1323
Xinhua Yan, Robert L. Price, Masaharu Nakayama, Kenta Ito, Adam J. T. Schuldt, Warren J. Manning, Atsushi Sanbe, Thomas K. Borg, Jeffrey Robbins, and Beverly H. Lorell
American Journal of Physiology-Heart and Circulatory Physiology, 2003, Volume 285, Number 5, Page H2179
Colin Selman and Christiaan Leeuwenburgh
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003, Volume 284, Number 2, Page R538
Bernhard Brüne
Cell Death & Differentiation, 2003, Volume 10, Number 8, Page 864
Collins Otieno Asweto, Jing Wu, Mohamed Ali Alzain, Hejing Hu, Sebastian Andrea, Lin Feng, Xiaozhe Yang, Junchao Duan, and Zhiwei Sun
Environmental Toxicology and Pharmacology, 2017
Silvina S. Bombicino, Darío E. Iglesias, Ivana A. Rukavina-Mikusic, Bruno Buchholz, Ricardo J. Gelpi, Alberto Boveris, and Laura B. Valdez
Free Radical Biology and Medicine, 2017, Volume 112, Page 267
Kimberly W. Raines, Guan-Liang Cao, Supatra Porsuphatana, Pei Tsai, Gerald M. Rosen, and Paul Shapiro
Journal of Biological Chemistry, 2004, Volume 279, Number 6, Page 3933
Swati Basu, Natalia A. Azarova, Michael D. Font, S. Bruce King, Neil Hogg, Mark T. Gladwin, Sruti Shiva, and Daniel B. Kim-Shapiro
Journal of Biological Chemistry, 2008, Volume 283, Number 47, Page 32590
Geoffrey A. Walford, Rose-Laure Moussignac, Anne W. Scribner, Joseph Loscalzo, and Jane A. Leopold
Journal of Biological Chemistry, 2004, Volume 279, Number 6, Page 4425
So-Young Lim, Jung-Hee Jang, Hye-Kyung Na, Shelly C. Lu, Irfan Rahman, and Young-Joon Surh
Journal of Biological Chemistry, 2004, Volume 279, Number 44, Page 46263
Zhangjian Huang, Junjie Fu, and Yihua Zhang
Journal of Medicinal Chemistry, 2017
Chi-Hsiao Yeh, Yu-Min Lin, Yi-Cheng Wu, Yao-Chang Wang, and Pyng Jing Lin
The Journal of Thoracic and Cardiovascular Surgery, 2004, Volume 128, Number 2, Page 180
Panagiotis Lepetsos and Athanasios G. Papavassiliou
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016, Volume 1862, Number 4, Page 576
L. Tao, E. Gao, N. S. Bryan, Y. Qu, H.-R. Liu, A. Hu, T. A. Christopher, B. L. Lopez, J. Yodoi, W. J. Koch, M. Feelisch, and X. L. Ma
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 31, Page 11471
Bogdan Calenic, Kazuhiko Okamura, Ken Yaegaki, Serban Tovaru, Tomoko Tanaka, and Toshio Imai
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2014, Volume 26, Number 2, Page 221
Emanuele Marzetti, Riccardo Calvani, Matteo Cesari, Thomas W. Buford, Maria Lorenzi, Bradley J. Behnke, and Christiaan Leeuwenburgh
The International Journal of Biochemistry & Cell Biology, 2013, Volume 45, Number 10, Page 2288
Alexis D. Ostrowski, Brian F. Lin, Matthew V. Tirrell, and Peter C. Ford
Molecular Pharmaceutics, 2012, Volume 9, Number 10, Page 2950
Yuan Gao, Li Li, Jianjun Zhang, Feng Su, Zhenhua Gong, Yisheng Lai, and Yihua Zhang
Archives of Pharmacal Research, 2012, Volume 35, Number 7, Page 1177
Fei Yin, Alberto Boveris, and Enrique Cadenas
Antioxidants & Redox Signaling, 2014, Volume 20, Number 2, Page 353
He-Ping Chen, Ming He, Zhu-Jun Mei, Qi-Ren Huang, and Min Huang
Canadian Journal of Physiology and Pharmacology, 2012, Volume 90, Number 7, Page 873
M.T Viscomi, F Florenzano, D Conversi, G Bernardi, and M Molinari
Neuroscience, 2004, Volume 123, Number 2, Page 393
Stefania Comes, Annamaria Locascio, Francesco Silvestre, Marco d'Ischia, Gian Luigi Russo, Elisabetta Tosti, Margherita Branno, and Anna Palumbo
Developmental Biology, 2007, Volume 306, Number 2, Page 772
P. Aguilar-Melero, G. Ferrín, and J. Muntané
Journal of Proteomics, 2012, Volume 75, Number 3, Page 740
Lei Lv, Shi-Sen Jiang, Jun Xu, Jian-Bin Gong, and Yan Cheng
Clinical and Experimental Pharmacology and Physiology, 2012, Volume 39, Number 1, Page 20
Elvira Brunelli, Ida Perrotta, Erminia Talarico, and Sandro Tripepi
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005, Volume 142, Number 2, Page 249
Michael J. Rose, Marilyn M. Olmstead, and Pradip K. Mascharak
Polyhedron, 2007, Volume 26, Number 16, Page 4713
Xiaozhong Hu, Decong Hu, and Ying Xu
Environmental Toxicology and Pharmacology, 2009, Volume 27, Number 3, Page 327
Agnieszka Janczyk, Agnieszka Wolnicka-Glubisz, Antonina Chmura, Martyna Elas, Zenon Matuszak, Grazyna Stochel, and Krystyna Urbanska
Nitric Oxide, 2004, Volume 10, Number 1, Page 42
Sergio Huerta, Guillermina Baay-Guzman, Cesar R. Gonzalez-Bonilla, Edward H. Livingston, Sara Huerta-Yepez, and Benjamin Bonavida
Nitric Oxide, 2009, Volume 20, Number 3, Page 182
Takuya Numata, Takeshi Saito, Kazuyo Maekawa, Yasumitsu Takahashi, Hiroshi Saitoh, Toshiyuki Hosokawa, Hiroyoshi Fujita, and Masaaki Kurasaki
Biochemical and Biophysical Research Communications, 2002, Volume 297, Number 3, Page 517
Fumiya Hongo, Hermes Garban, Sara Huerta-Yepez, Mario Vega, Ali R. Jazirehi, Yoichi Mizutani, Tsuneharu Miki, and Benjamin Bonavida
Biochemical and Biophysical Research Communications, 2005, Volume 336, Number 2, Page 692
Amy Bishop, Shaw-Fang Yet, Mu-En Lee, Mark A. Perrella, and Bruce Demple
Biochemical and Biophysical Research Communications, 2004, Volume 325, Number 1, Page 3
Frank Petrat, Tongju Li, Nathalie Dehne, Herbert de Groot, and Ursula Rauen
Life Sciences, 2006, Volume 79, Number 17, Page 1606
Enrique Cadenas
Molecular Aspects of Medicine, 2004, Volume 25, Number 1-2, Page 17
Laura B. Valdez, Tamara Zaobornyj, Silvia Alvarez, Juanita Bustamante, Lidia E. Costa, and Alberto Boveris
Molecular Aspects of Medicine, 2004, Volume 25, Number 1-2, Page 49
Jim C. Oates and Gary S. Gilkeson
Clinical Immunology, 2006, Volume 121, Number 3, Page 243
Robin J. Goody, Cristen C. Hoyt, and Kenneth L. Tyler
Experimental Neurology, 2005, Volume 195, Number 2, Page 379
Han-Ming Shen and Zheng-gang Liu
Free Radical Biology and Medicine, 2006, Volume 40, Number 6, Page 928
Michael J. Rose and Pradip K. Mascharak
Coordination Chemistry Reviews, 2008, Volume 252, Number 18-20, Page 2093
Aura A Eroy-Reveles and Pradip K Mascharak
Future Medicinal Chemistry, 2009, Volume 1, Number 8, Page 1497
Eric Solary, Ali Bettaieb, Laurence Dubrez-Daloz, and Laurent Corcos
Leukemia & Lymphoma, 2003, Volume 44, Number 4, Page 563
Bernhard Brüne
Antioxidants & Redox Signaling, 2005, Volume 7, Number 3-4, Page 497
Alberto Boveris, Gabriela D'Amico, Silvia Lores-Arnaiz, and Lidia E. Costa
Antioxidants & Redox Signaling, 2003, Volume 5, Number 6, Page 691
Alberto Boveris, Laura B. Valdez, Silvia Alvarez, Tamara Zaobornyj, Alejandro D. Boveris, and Ana Navarro
Antioxidants & Redox Signaling, 2003, Volume 5, Number 3, Page 265
Narasimham L. Parinandi, Ashish Sharma, Timothy D. Eubank, Bruce F. Kaufman, Vijay Kumar Kutala, Clay B. Marsh, Louis J. Ignarro, and Periannan Kuppusamy
Antioxidants & Redox Signaling, 2007, Volume 9, Number 11, Page 1837
N. Dehne, T. Li, F. Petrat, U. Rauen, and H. de Groot
Biological Chemistry, 2004, Volume 385, Number 3-4
L. A. Ridnour, D. D. Thomas, D. Mancardi, M. G. Espey, K. M. Miranda, N. Paolocci, M. Feelisch, J. Fukuto, and D. A. Wink
Biological Chemistry, 2004, Volume 385, Number 1, Page 1
Yang Wu, Zhong-yuan Xia, Qing-tao Meng, Jie Zhu, Shaoqing Lei, Jinjin Xu, and Juan Dou
Journal of Biomedicine and Biotechnology, 2011, Volume 2011, Page 1
Jue Tian, Zi Yan, Ye Wu, Su-li Zhang, Ke Wang, Xiu-rui Ma, Li Guo, Jin Wang, Lin Zuo, Jing-yi Liu, Lin Quan, and Hui-rong Liu
Acta Pharmacologica Sinica, 2010, Volume 31, Number 10, Page 1324
J. Pourova, M. Kottova, M. Voprsalova, and M. Pour
Acta Physiologica, 2010, Volume 198, Number 1, Page 15
Rocío Pérez-Rodríguez, Cesáreo Roncero, Ana María Oliván, María Pilar González, and María Jesús Oset-Gasque
Journal of Neurochemistry, 2009, Volume 108, Number 4, Page 1083
Thorsten Hagemann, Toby Lawrence, Iain McNeish, Kellie A. Charles, Hagen Kulbe, Richard G. Thompson, Stephen C. Robinson, and Frances R. Balkwill
The Journal of Experimental Medicine, 2008, Volume 205, Number 6, Page 1261
Jim C. Oates, Stephanie R. Shaftman, Sally E. Self, and Gary S. Gilkeson
Arthritis & Rheumatism, 2008, Volume 58, Number 1, Page 263
James C. Oates, Libby W. Farrelly, Ann F. Hofbauer, Wei Wang, and Gary S. Gilkeson
Arthritis & Rheumatism, 2007, Volume 56, Number 11, Page 3738
Aura A. Eroy-Reveles, C. Gianna Hoffman-Luca, and Pradip K. Mascharak
Dalton Transactions, 2007, Number 45, Page 5268
Carolyn Jack, Jack Antel, Wolfgang Brück, and Tanja Kuhlmann
Glia, 2007, Volume 55, Number 9, Page 926
G. Sorarù, L. Vergani, L. Fedrizzi, C. D?Ascenzo, A. Polo, B. Bernazzi, and C. Angelini
Neuropathology and Applied Neurobiology, 2007, Volume 33, Number 2, Page 204
Yinghui Huang, Casey Lee, Per Borgström, and Ruth A Gjerset
Molecular Therapy, 2007, Volume 15, Number 3, Page 524
Istvan Szundi, Michael J. Rose, Indranil Sen, Aura A. Eroy-Reveles, Pradip K. Mascharak, and Ólöf Einarsdóttir
Photochemistry and Photobiology, 2006, Volume 82, Number 5, Page 1377
Stanley Muravchick and Richard J. Levy
Anesthesiology, 2006, Volume 105, Number 4, Page 819
D.-Y. Li, L. Tao, H. Liu, T. A. Christopher, B. L. Lopez, and X. L. Ma
Apoptosis, 2006, Volume 11, Number 6, Page 923
J.L. Viñas, A. Sola, and G. Hotter
Kidney International, 2006, Volume 69, Number 8, Page 1403
Zheng-Guo Cui, Takashi Kondo, and Hideki Matsumoto
Journal of Cellular Physiology, 2006, Volume 206, Number 2, Page 468
Zhao Zhong Chong, Jing-Qiong Kang, and Kenneth Maiese
Journal of Cerebral Blood Flow & Metabolism, 2003, Page 320
Cory D. Bishop and Bruce P. Brandhorst
Evolution and Development, 2003, Volume 5, Number 5, Page 542
Rainer Wolber, Franz Stab, Heiner Max, Annegret Wehmeyer, Ina Hadshiew, Horst Wenck, Frank Rippke, and Klaus-Peter Wittern
Journal der Deutschen Dermatologischen Gesellschaft, 2004, Volume 2, Number 7, Page 580
Juergen Frank, Christine Lambert, Hans Konrad Biesalski, Oliver Thews, Peter Vaupel, and Debra K. Kelleher
International Journal of Cancer, 2003, Volume 107, Number 6, Page 941

Comments (0)

Please log in or register to comment.
Log in