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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 395, Issue 5

Issues

Tetracycline antibiotics and resistance mechanisms

Fabian Nguyen
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
  • Other articles by this author:
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/ Agata L. Starosta
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
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/ Stefan Arenz
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
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/ Daniel Sohmen
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
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/ Alexandra Dönhöfer
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
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/ Daniel N. Wilson
  • Corresponding author
  • Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
  • Center for Integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany
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Published Online: 2014-02-05 | DOI: https://doi.org/10.1515/hsz-2013-0292

Abstract

The ribosome and protein synthesis are major targets within the cell for inhibition by antibiotics, such as the tetracyclines. The tetracycline family of antibiotics represent a large and diverse group of compounds, ranging from the naturally produced chlortetracycline, introduced into medical usage in the 1940s, to second and third generation semi-synthetic derivatives of tetracycline, such as doxycycline, minocycline and more recently the glycylcycline tigecycline. Here we describe the mode of interaction of tetracyclines with the ribosome and mechanism of action of this class of antibiotics to inhibit translation. Additionally, we provide an overview of the diverse mechanisms by which bacteria obtain resistance to tetracyclines, ranging from efflux, drug modification, target mutation and the employment of specialized ribosome protection proteins.

Keywords: glycylcycline; resistance; ribosome; tetracycline; tigecycline; translation

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About the article

Corresponding author: Daniel N. Wilson, Gene Center and Department of Biochemistry, University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany; and Center for Integrated Protein Science Munich (CiPSM), University of Munich, Feodor-Lynenstr. 25, D-81377 Munich, Germany, e-mail:


Received: 2013-12-06

Accepted: 2014-01-30

Published Online: 2014-02-05

Published in Print: 2014-05-01


Citation Information: Biological Chemistry, Volume 395, Issue 5, Pages 559–575, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/hsz-2013-0292.

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