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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 49, Issue 7

Issues

No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population

Peter Bugert
  • Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany
  • P. Bugert and E. Elmas contributed equally to this work.
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/ Elif Elmas
  • 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
  • P. Bugert and E. Elmas contributed equally to this work.
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/ Ksenija Stach
  • 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
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/ Christel Weiss
  • Department of Medical Statistics, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
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/ Thorsten Kälsch
  • 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
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/ Dobromir Dobrev
  • 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
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/ Martin Borggrefe
  • 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
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Published Online: 2011-05-17 | DOI: https://doi.org/10.1515/CCLM.2011.190

Abstract

Background: In a recently published genome-wide association study (GWAS), three single nucleotide polymorphisms (SNPs) (rs2824292, rs1353342, rs12090554) were significantly associated with increased susceptibility for ventricular fibrillation (VF) during acute myocardial infarction (AMI). The association of rs2824292 could be confirmed in a second cohort. Both cohorts were from the Netherlands. We aimed to replicate this association in a German cohort of AMI patients with or without VF.

Methods: We included a German cohort of 90 individuals with AMI and VF (cases) and 167 AMI individuals without VF and used Taqman assays for SNP typing.

Results: None of the loci showed evidence for a statistically significant association with VF. The observed genotype frequencies of the three loci were in Hardy-Weinberg equilibrium, which essentially excludes genotyping errors.

Conclusions: In contrast to the data from the Netherlands, we could not detect a significant association of the rs2824292 locus and risk of VF during AMI in our German cohort. Differences in recruitment and clinical phenotypes between the Dutch and German cohorts may underlie different genotype associations.

Keywords: single nucleotide polymorphisms; sudden cardiac death; ventricular fibrillation

About the article

Corresponding author: Elif Elmas, Associate Professor, 1st Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany Phone: +49-621-383-2204, Fax: +49-621-383-3821


Received: 2011-01-04

Accepted: 2011-02-14

Published Online: 2011-05-17

Published in Print: 2011-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 49, Issue 7, Pages 1237–1239, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.190.

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