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Open Chemistry

formerly Central European Journal of Chemistry


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Volume 10, Issue 1

Issues

Volume 13 (2015)

Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method

Marcin Koba / Mariusz Belka / Tomasz Ciesielski / Tomasz Bączek
Published Online: 2011-11-24 | DOI: https://doi.org/10.2478/s11532-011-0131-6

Abstract

The lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log kw values (i.e., the retention factor log kw extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log kw) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log kw) and log P data calculated using some commonly available software, are discussed.

Keywords: Lipophilicity; Gradient reversed-phase high-performance liquid chromatography (RP-HPLC)

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About the article

Published Online: 2011-11-24

Published in Print: 2012-02-01


Citation Information: Open Chemistry, Volume 10, Issue 1, Pages 216–223, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-011-0131-6.

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© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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