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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

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Volume 27, Issue 7-8


Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents

Emel Torun
  • Corresponding author
  • Department of Pediatrics, Bezmialem Vakif University Hospital, Adnan Menderes Avenue, P.K.: 3409 Fatih, Istanbul
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/ Selim Gökçe
  • Department of Pediatric Gastroenterology, Bezmialem Vakif University Medical Faculty, Istanbul
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/ lker Tolga Ozgen
  • Department of Pediatric Endocrinology and Metabolism, Bezmialem Vakif University Medical Faculty, Istanbul
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/ Sinem Aydın / Yasar Cesur
  • Department of Pediatric Endocrinology and Metabolism, Bezmialem Vakif University Medical Faculty, Istanbul
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Published Online: 2014-03-29 | DOI: https://doi.org/10.1515/jpem-2013-0337


Objective: Oxidative stress has been reported to be involved in the pathogenesis of metabolic disorders related with obesity. The aim of the study was to investigate the association of oxidative stress and paraoxonase activities with non-alcoholic fatty liver disease (NAFLD) as well as metabolic syndrome.

Materials and methods: A total of 109 obese children and adolescents and 44 healthy and lean control subjects were enrolled in the study. According to their ultrasonographic steatosis scores, they were classified into four groups as follows: healthy children; obese, non-NAFLD; obese, grade I-NAFLD; and obese, grade II–III NAFLD. The biochemical parameters and insulin resistance (HOMA-IR) were evaluated from fasting samples. The plasma total antioxidant status (TAS), total oxidant status (TOS), and serum paraoxonase activities were measured and then oxidative stress index (OSI) was calculated as the indicator of degree of oxidative stress.

Results: As the steatosis increased, the alanine aminotransferase, C-reactive protein, HOMA-IR, total cholesterol, and LDL cholesterol increased, whereas HDL cholesterol decreased. The TAS measurements were higher in the obese NAFLD group compared with that of the healthy control group. The TOS and OSI measurements did not differ between the groups. Paraoxonase activities increased significantly as steatosis increased.

Conclusions: Among the children in this study, no relationship could be demonstrated between obesity with/without steatosis and oxidant/antioxidant status.

Keywords: hepatosteatosis; paraoxonase; total antioxidant stress; total oxidant stress


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About the article

Corresponding author: Emel Torun, MD, Department of Pediatrics, Bezmialem Vakif University Hospital, Adnan Menderes Avenue, P.K.: 3409 Fatih, Istanbul, Phone: +0090/212 453-1700, Fax: +0090/212 621-7580, E-mail:

Received: 2013-08-20

Accepted: 2014-02-18

Published Online: 2014-03-29

Published in Print: 2014-07-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 27, Issue 7-8, Pages 667–675, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0337.

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