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Publicly Available Published by De Gruyter January 18, 2011

Synthesis of mycalazol and mycalazal analogs with potent antiproliferating activities

Yasser M. A. Mohamed and Trond Vidar Hansen

Four 2,5-disubstituted pyrrole and two 2-disubstituted thiophene analogs of the natural products mycalazol 5 and mycalazal 2 have been prepared using the Stille coupling reaction. All four analogs displayed potent antiproliferating activity against several human cancer cell lines with IC50 values in the nanomolar range.


Conference

International Conference on Organic Synthesis (ICOS-18), International Conference on Organic Synthesis, ICOS, Organic Synthesis, 18th, Bergen, Norway, 2010-08-01–2010-08-06


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Online erschienen: 2011-1-18
Erschienen im Druck: 2011-1-18

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