Skip to content
Publicly Available Published by De Gruyter April 29, 2012

Bioactive cubitane diterpenoids from a Colombian gorgonian species of the genus Eunicea

  • Xiaomei Wei , Karinel Nieves and Abimael D. Rodríguez

Two new diterpenes having the rare cubitane skeleton were isolated from a southwestern Caribbean gorgonian coral of the genus Eunicea. The structures of the new metabolites, as well as those of three known cubitanes were elucidated by extensive spectroscopic analysis. One compound showed significant in vitro cytotoxic activity against a National Cancer Institute (NCI) panel of cancer cell lines, whereas the remaining metabolites were shown to exert mild antitubercular and antimalarial activities against the pathogenic microbes Mycobacterium tuberculosis and Plasmodium falciparum.


Conference

IUPAC Congress, IUPAC Congress, CONGRESS, IUPAC Congress, 43rd, San Juan, Puerto Rico, 2011-07-30–2011-08-07


References

1 10.1039/b821918b, F. Berrue, R. G. Kerr. Nat. Prod. Rep.26, 681 (2009).Search in Google Scholar

2 10.1016/0040-4020(95)00216-U, A. D. Rodríguez. Tetrahedron51, 4571 (1995).Search in Google Scholar

3 10.1016/j.tet.2004.09.108, X. Wei, A. D. Rodríguez, P. Baran, R. G. Raptis, J. A. Sánchez, E. Ortega-Barria, J. González. Tetrahedron60, 11813 (2004).Search in Google Scholar

4 10.1021/np100074r, X. Wei, A. D. Rodríguez, P. Baran, R. G. Raptis. J. Nat. Prod.73, 925 (2010).Search in Google Scholar PubMed PubMed Central

5 10.1021/ja00476a056, G. D. Prestwich, D. F. Weimer, J. Meinwald, J. Clardy. J. Am. Chem. Soc.100, 2560 (1978).Search in Google Scholar

6 10.1021/jo00182a019, S. A. Look, W. Fenical, Z. Qi-tai, J. Clardy. J. Org. Chem.49, 1417 (1984).Search in Google Scholar

7 10.1021/jo00003a053, J. Shin, W. Fenical. J. Org. Chem.56, 1227 (1991).Search in Google Scholar

8 K. I. Marville, W. F. Reynolds, R. L. Sealy, W. F. Tinto. Heterocycles63, 107 (2004).10.3987/COM-03-9902Search in Google Scholar

9 10.1021/ja00387a059, M. M. Bandurraga, W. Fenical, S. F. Donovan, J. Clardy. J. Am. Chem. Soc.104, 6463 (1982).Search in Google Scholar

10 10.1016/j.tet.2006.04.070, J. Marrero, C. A. Ospina, A. D. Rodríguez, P. Baran, H. Zhao, S. G. Franzblau, E. Ortega-Barria. Tetrahedron62, 6998 (2006).Search in Google Scholar

11 10.1111/j.1096-3642.2008.00515.x, J. A. Sánchez. Zool. J. Linn. Soc.157, 237 (2009).Search in Google Scholar

12 10.1039/c005001f, J. W. Blunt, B. R. Copp, M. H. G. Munro, P. T. Northcote, M. R. Prinsep. Nat. Prod. Rep.28, 196 (2011) and previous reports in this series.Search in Google Scholar PubMed

13 10.1021/ol902854t, E. Schöttner, M. Wiechoczek, P. G. Jones, T. Lindel. Org. Lett.12, 784 (2010).Search in Google Scholar PubMed

14 L. A. Collins, S. G. Franzblau. Antimicrob. Agents Chemother.41, 1004 (1997).Search in Google Scholar

15 Y. Corbett, L. Herrera, J. González, L. Cubilla, T. Capson, P. D. Colley, T. A. Kursar, L. I. Romero, E. Ortega-Barria. J. Trop. Med. Hyg.70, 119 (2004).Search in Google Scholar

Online erschienen: 2012-4-29
Erschienen im Druck: 2012-4-30

© 2013 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 9.6.2023 from https://www.degruyter.com/document/doi/10.1351/PAC-CON-11-10-20/html
Scroll to top button