Change language
English Deutsch
Change currency
€ EUR £ GBP $ USD
Publicly Available Published by De Gruyter January 1, 2009

Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

  • Mario C. Foti , Sunil K. Sharma , Gaurav Shakya , Ashok K. Prasad , Giovanni Nicolosi , Paolo Bovicelli , Balaram Ghosh , Hanumantharao G. Raj , Ramesh C. Rastogi and Virinder S. Parmar
From the journal Pure and Applied Chemistry
https://doi.org/10.1351/pac200577010091
Download article (PDF)

Abstract

A wide variety of polyphenolic compounds (i.e., 4-methylcoumarins, xanthones, pyrazoles, and pyrazolylacrylonitriles) have been examined for their antioxidant effect on NADPH-catalyzed liver-microsomal lipid peroxidation with a view to establishing their structure–activity relationship. Dihydroxy-/diacetoxy-4-methylcoumarin derivatives have been shown to be radical scavengers. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells. 1,4-Dihydroxyxanthone showed enhanced antioxidant activity as well as ICAM-1 inhibitory activity.

Keywords: acrylonitriles; antioxidants; coumarins; ICAM-1; lipid peroxidation; peroxyls; pyrazoles; xanthones

Conference

International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, International Conference on Biodiversity, International Symposium on the Chemistry of Natural Products, ICOB, ISCNP, Biodiversity, Natural Products, 24th, Delhi, India, 2004-01-26–2004-01-31

Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

Download article (PDF)
From the journal
Pure and Applied Chemistry
Pure and Applied Chemistry
Volume 77 Issue 1
Submit manuscript

Journal and Issue

Articles in the same Issue

Natural products chemistry and phytomedicine in the 21st century: New developments and challenges
Biodiversity: A continuing source of novel drug leads
Investigations toward new lead compounds from medicinally important plants
Biological activity from indigenous medicinal plants of Mauritius
Discovery of drug candidates from some Turkish plants and conservation of biodiversity
New anti-invasive compounds: Results from the Indo-Belgian screening program
Biodiversity as a source of new pharmacophores: A new theory of memory III
Diverse metabolites of coral reef organisms
Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project
Approaches to the stereoselective total synthesis of biologically active natural products
From 3,3,4,4-tetraethoxybutyne to carbohydrate mimics
Noniterative approach to the total asymmetric synthesis of 15-carbon polyketides and analogs with high stereodiversity
Use of furans in synthesis of bioactive compounds
Chemistry of tetrathiomolybdate and tetraselenotungstate: Applications in carbohydrate chemistry
Creating chemical diversity space by scaffold decoration of dihydropyrimidines
Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis
Novel pyrrole-containing hypoglycemic and hypotriglyceridemic compounds
Synthesis of novel non-isoprenoid phenolic acids and 3-alkylpyridines
Novel anti-infective compounds
Indo-U.S. collaborative studies on biocatalytic generation of novel molecular architectures
Biocatalytic routes toward pharmaceutically important precursors and novel polymeric systems
Gel-immobilized enzymes as promising biocatalysts: Results from Indo-Russian collaborative studies
Selective transacylation reactions on 4-aryl-3,4-dihydropyrimidin-2-ones and nucleosides mediated by novel lipases
Acetoxy drug: protein transacetylase: A novel enzyme-mediating protein acetylation by polyphenolic peracetates
Production of a novel alkaline lipase by Fusarium globulosum using neem oil, and its applications
Biocatalytic synthesis of novel electronic and photovoltaic materials
Biocatalytic production of flavors and fragrances
Plasmodium falciparum triosephosphate isomerase: New insights into an old enzyme
Electrostatic cross-modulation of the pseudoaromatic character in single-stranded RNA by nearest-neighbor interactions
Identification of target genes of microRNAs in retinoic acid-induced neuronal differentiation
Novel nucleic acid architectures involving locked nucleic acid (LNA) and pyrene residues: Results from an Indo-Danish collaboration
Forced intercalation as a tool in gene diagnostics and in studying DNA–protein interactions
Biocatalytic approaches for synthesis of conducting polyaniline nanoparticles
Downloaded on 5.6.2023 from https://www.degruyter.com/document/doi/10.1351/pac200577010091/html
Scroll to top button