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Publicly Available Published by De Gruyter January 1, 2009

Approaches to the stereoselective total synthesis of biologically active natural products

  • Anne Baron , Matthew Ball , Benjamin Bradshaw , Sam Donnelly , Olivier Germay , Pilar C. Oller , Naresh Kumar , Nathaniel Martin , Matthew O’Brien , Hiroki Omori , Christopher Moore and Eric J. Thomas


Total syntheses of epothilone B and pamamycin 607, which feature reactions between functionalized allylstannanes and aldehydes to introduce a (Z)-trisubstituted double-bond and remote stereocenters stereoselectively, are discussed. Recent work concerned with carrying out this chemistry without the use of allylstannanes as starting materials and progress toward a total synthesis of bryostatins are also presented.


International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, International Conference on Biodiversity, International Symposium on the Chemistry of Natural Products, ICOB, ISCNP, Biodiversity, Natural Products, 24th, Delhi, India, 2004-01-26–2004-01-31

Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

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