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Publicly Available Published by De Gruyter January 1, 2009

Identification of target genes of microRNAs in retinoic acid-induced neuronal differentiation

  • Hiroaki Kawasaki and Kazunari Taira
From the journal Pure and Applied Chemistry
https://doi.org/10.1351/pac200577010313
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Abstract

MicroRNAs (miRNAs) are phylogenetically widespread, small noncoding RNAs of 18–25 nucleotides in length, and are expressed in animals and plants. These small RNAs can regulate gene expression at the translational level through interactions with their target messenger RNAs, and have a role in the development of Caenorhabditis elegans, plants, and mammals. Although more than 200 miRNAs have been found in mammals, it is not easy to identify their targets. We investigated the target genes of miRNAs and analyzed the function of these miRNAs during retinoic acid (RA)-induced neuronal differentiation.

Keywords: differentiation; HES1; microRNA; neuron; RNAi; siRNA

Conference

International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, International Conference on Biodiversity, International Symposium on the Chemistry of Natural Products, ICOB, ISCNP, Biodiversity, Natural Products, 24th, Delhi, India, 2004-01-26–2004-01-31

Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

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From the journal
Pure and Applied Chemistry
Pure and Applied Chemistry
Volume 77 Issue 1
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