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Publicly Available Published by De Gruyter January 1, 2009

Carbohydrates as versatile platforms in the construction of small compound libraries

Mattie S. M. Timmer, Steven H. L. Verhelst, Gijsbert M. Grotenbreg, Mark Overhand and Herman S. Overkleeft

Abstract

This paper presents our recent results concerning the use of carbohydrates as cheap, chiral, and enantiopure starting materials in the construction of a variety of densely functionalized molecules. The compatibility of ring-closing metathesis with standard carbohydrate chemistry is demonstrated in the synthesis of new stereoisomers of deoxystreptamine and neamine–important building blocks for the generation of synthetic aminoglycosides with potential antibacterial activity. Ring-closing metathesis is also a key step in the rapid synthesis of new indolizidines and quinolizidines, and in a new solid-phase assisted carbohydrate-based combinatorial scaffold strategy. Further, some of our latest results in the conformational analysis of sugar amino acid-based peptide mimetics and in the development of a novel Ugi-type three-component reaction of sugar-derived azido-aldehydes are discussed.


Conference

International Conference on Organic Synthesis (ICOS-15), International Conference on Organic Synthesis, ICOS, Organic Synthesis, 15th, Nagoya, Japan, 2004-08-01–2004-08-06


Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

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