Frontmatter
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i |
Contents
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v |
Preface
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xix |
Comments on the book Extracellular Matrix: Pathobiology & Signaling
Dick Heinegård
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xxiii |
About the Editor/Section Editors
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xxv |
List of contributing authors
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xxix |
Abbreviations and acronyms used
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xxxix |
1 An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling
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1.1 Extracellular matrix: a functional scaffold
Achilleas Theocharis, Chrisostomi Gialeli, Vincent Hascall and Nikos K. Karamanos
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3 |
2 Insights into the function of glycans
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2.1 Introduction
Paraskevi Heldin
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23 |
2.2 Metabolic control of hyaluronan synthesis
Alberto Passi, Giancarlo De Luca, Evgenia Karousou, Davide Vigetti and Manuela Viola
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2.3 Multiple roles of hyaluronan as a target and modifier of the inflammatory response
Sanna Oikari, Tiina A. Jokela, Raija H. Tammi and Markku I. Tammi
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39 |
2.4 Roles of sulfated and nonsulfated glycosaminoglycans in cancer growth and progression-therapeutic implications
Dragana Nikitovic and George N. Tzanakakis
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66 |
2.5 Heparan sulfate design: regulation of biosynthesis
Dagmar S. Pikas, Anh-Tri Do, Audrey Deligny, Anders Dagälv and Lena Kjelle
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84 |
2.6 Bone and skin disorders caused by a disturbance in the biosynthesis of chondroitin sulfate and dermatan sulfate
Shuji Mizumoto and Kazuyuki Sugahara
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2.7 Biological functions of branched N-glycans related to physiology and pathology of extracellular matrix
Congxiao Gao, Kazuaki Ohtsubo, Jianguo Gu and Naoyuki Taniguchi
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3 Proteoglycans: structure, pathobiology, and signaling
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3.1 Introduction
Liliana Schaefer
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135 |
3.2 Aggrecan in skeletal development and regenerative medicine
Anna Plaas, Daniel J. Gorski, Jennifer Velasco, Colton McNicols, Rebecca Bell, Vincent Wang and John Sandy
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141 |
3.3 The pathobiology of versican
Thomas N. Wight
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154 |
3.4 The biology of perlecan and its bioactive modules
Chris D. Willis, Liliana Schaefer and Renato V. Iozzo
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171 |
3.5 Small leucine-rich proteoglycans: multifunctional signaling effectors
Rosetta Merline, Madalina V. Nastase, Renato V. Iozzo and Liliana Schaefer
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3.6 Structure and function of syndecans
Csilla Pataki and John R. Couchman
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197 |
3.7 The glypican family
Jorge Filmus and Mariana Capurro
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3.8 Serglycin proteoglycan: implications for thrombosis, inflammation, atherosclerosis, and metastasis
Barbara P. Schick
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4 Matrix Proteinases: biological significance in health and disease
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4.1 Introduction
Jan-Olof Winberg
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235 |
4.2 Extracellular functions of cysteine proteases
Harald Thidemann Johansen and Rigmor Solberg
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239 |
4.3 Plasmin and the plasminogen activator system in health and disease
Gunbjørg Svineng, Synnøve Magnussen and Elin Hadler-Olsen
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261 |
4.4 Matrix metalloproteinase complexes and their biological significance
Bodil Fadnes, Elin Hadler-Olsen, Ingebrigt Sylte, Lars Uhlin-Hansen and Jan-Olof Winberg
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291 |
4.5 The ADAMTS family of metalloproteinases
Hideaki Nagase
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4.6 Proteinases in wound healing
Mervi Toriseva and Veli-Matti Kähäri
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4.7 Rock, paper, and molecular scissors: regulating the game of extracellular matrix homeostasis, remodeling, and inflammation
Antoine Dufour and Christopher M. Overall
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5 ECM cell surface receptors
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5.1 Introduction
Donald Gullberg
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403 |
5.2 Integrin function in heart fibrosis: mechanical strain, transforming growth factor-beta 1 activation, and collagen glycation
Boris Hinz and Christopher A. McCulloch
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406 |
5.3 Cancer-associated fibroblast integrins as therapeutic targets in the tumor microenvironment
Ning Lu, Cord Brakebusch and Donald Gullberg
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432 |
5.4 Discoidin domain receptors: non-integrin collagen receptors on the move
Antonio S. Rocca and Michelle P. Bendeck
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451 |
5.5 Syndecans as receptors for pericellular molecules
Xiaojie Xian, James R. Whiteford and John R. Couchman
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5.6 CD44: a Sensor of tissue damage critical for restoring homeostasis
Ellen Puré
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484 |
6 Collagens: insights into the folding, assembly and functions
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6.1 Introduction
Ruggero Tenni
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501 |
6.2 Trimerization domains in collagens: chain selection, folding initiation, and triple-helix stabilization
Sergei P. Boudko and Hans Peter Bächinger
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506 |
6.3 Structural basis of collagen missense mutations
Anton V. Persikov and Barbara Brodsky
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521 |
6.4 Roles and regulation of BMP1/Tolloid-like proteinases: collagen/matrix assembly, growth factor activation, and beyond
Catherine Moali and David J. S. Hulmes
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539 |
6.5 Supramolecular assembly of type I collagen
Mario Raspanti
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562 |
6.6 Collagen interactomes: mapping functional domains and mutations on fibrillar and network-forming collagens
James D. San Antonio, J. Des Parkin, Judy Savige, Joseph P. R. O. Orgel and Olena Jacenko
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575 |
6.7 Collagen-binding proteins
Takako Sasaki
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592 |
7 Emerging aspects in extracellular matrix pathobiology
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7.1 Introduction
Achilleas Theocharis
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605 |
7.2 Extracellular matrix in breast cancer: permissive and restrictive influences emanating from the stroma
Ida Pucci-Minafra
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610 |
7.3 EMMPRIN/CD147: potential functions in tumor microenvironment and therapeutic target for human cancer
Eric Huet, Eric E Gabison, Samia Mourah and Suzanne Menashi
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626 |
7.4 Implication of hyaluronidases in cancer growth, metastasis, diagnosis, and treatment
Irene-Eva Triantaphyllidou, Serafoula Filou, Helen Bouga, Constantine Kolliopoulos and Demitrios H. Vynios
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639 |
7.5 Structure-function relationship of syndecan-1, with focus on nuclear translocation and tumor cell behavior
Fang Zong, Ilona Kovalszky, Anders Hjerpe and Katalin Dobra
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653 |
7.6 Serglycin: a novel player in the terrain of neoplasia
Angeliki Korpetinou, Eleni Milia-Argeiti, Vassiliki Labropoulou and Achilleas Theocharis
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677 |
7.7 Quantifying cell-ECM pathobiology in 3D
Joseph S. Maffei and Muhammad H. Zaman
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689 |
7.8 Diabetic foot infections
Cecilia Rydén
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703 |
8 Targeting tumor microenvironment at the ECM level
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8.1 Introduction
Nikos K. Karamanos
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719 |
8.2 Targeting the tumor microenvironment in cancer progression
Suniti Misra, Vincent C. Hascall, Nikos K. Karamanos, Roger R. Markwald and Shibnath Ghatak
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723 |
8.3 Growth factor signaling and extracellular matrix
Dragana Nikitovic, Harris Pratsinis, Aikaterini Berdiaki, Chrisostomi Gialeli, Dimitris Kletsas and George N. Tzanakakis
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741 |
8.4 Targeting protein-glycan interactions at cell surface during EMT and hematogenous metastasis: consequences on tumor invasion and metastasis
Mauro S. G. Pavao, Eliene O. Kozlowski and Felipe C.O.B. Teixeira
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763 |
8.5 Pharmacological targeting of proteoglycans and metalloproteinases: an emerging aspect in cancer treatment
Spyros S. Skandalis, Chrisostomi Gialeli, Nikos Afratis, Alexios J. Aletras, Theodore Tsegenidis, Achilleas D. Theocharis and Nikos K. Karamanos
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785 |
8.6 Targeting syndecan shedding in cancer
Ralph D. Sanderson and John R. Couchman
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802 |
8.7 PG receptors with phosphatase action in cancer and angiogenesis
Marina Koutsioumpa and Evangelia Papadimitriou
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813 |
8.8 Heparanase, a multifaceted protein involved in cancer, chronic inflammation, and kidney dysfunction
Israel Vlodavsky, Michael Elkin, Benito Casu, Jin-Ping Li, Ralph D. Sanderson and Neta Ilan
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824 |
8.9 Delivery systems targeting cancer at the level of ECM
Shibnath Ghatak, Vincent C. Hascall, Nikos K. Karamanos, Roger R. Markwald and Suniti Misra
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855 |
Index
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873 |