Extracellular Matrix: Pathobiology and Signaling

Published by De Gruyter 2012

Extracellular Matrix: Pathobiology and Signaling

In collaboration with: Donald Gullberg, Heldin Paraskevi, Liliana Schaefer, Ruggero Tenni, Achilleas Theocharis and Jan-Olof Winberg
Edited by: Nikos K. Karamanos

https://doi.org/10.1515/9783110258776

Overview
Contents

About this book

Over the last decades cell biology and biological chemistryhave increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.
It will provide an introduction to the extracellular matrix and detailed sections and chapters on:

Importance of extracellular matrix in health and disease
Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin)
Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system)
Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control)
Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases)
Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR).
Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics).

"The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications."

Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Comprehensive treatment of the extracellular matrix with special focus on matrix pathobiology and cell molecular biology
Role of the extracellular matrix in health and disease with outlook for biotechnological and pharmacological applications
High quality color illustrations

Author information

Nikos K. Karamanos, Biochem. Lab, Department of Chemistry, University of Patras, Greece.

Section-Editors: Donald Gullberg, Department of Biomedicine, University of Bergen, Norway; Paraskevi Heldin,Ludwig Institute for Cancer Research, Uppsala University,Sweden; Liliana Schaefer, Institute of General Pharmacology and Toxicology, Goethe-University, Frankfurt,Germany; Ruggero Tenni, Department of Biochemistry, Pavia University, Italy; Achilleas Theocharis, Department of Chemistry, University of Patras, Greece; Jan-Olof Winberg, Department of Medical Biology, University of Tromsø, Norway.

Supplementary Materials

Topics

Frontmatter Requires Authentication Unlicensed Licensed Download PDF	i
Contents Requires Authentication Unlicensed Licensed Download PDF	v
Preface Requires Authentication Unlicensed Licensed Download PDF	xix
Comments on the book Extracellular Matrix: Pathobiology & Signaling Dick Heinegård Requires Authentication Unlicensed Licensed Download PDF	xxiii
About the Editor/Section Editors Requires Authentication Unlicensed Licensed Download PDF	xxv
List of contributing authors Requires Authentication Unlicensed Licensed Download PDF	xxix
Abbreviations and acronyms used Requires Authentication Unlicensed Licensed Download PDF	xxxix
1 An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling
1.1 Extracellular matrix: a functional scaffold Achilleas Theocharis, Chrisostomi Gialeli, Vincent Hascall and Nikos K. Karamanos Requires Authentication Unlicensed Licensed Download PDF	3
2 Insights into the function of glycans
2.1 Introduction Paraskevi Heldin Requires Authentication Unlicensed Licensed Download PDF	23
2.2 Metabolic control of hyaluronan synthesis Alberto Passi, Giancarlo De Luca, Evgenia Karousou, Davide Vigetti and Manuela Viola Requires Authentication Unlicensed Licensed Download PDF	26
2.3 Multiple roles of hyaluronan as a target and modifier of the inflammatory response Sanna Oikari, Tiina A. Jokela, Raija H. Tammi and Markku I. Tammi Requires Authentication Unlicensed Licensed Download PDF	39
2.4 Roles of sulfated and nonsulfated glycosaminoglycans in cancer growth and progression-therapeutic implications Dragana Nikitovic and George N. Tzanakakis Requires Authentication Unlicensed Licensed Download PDF	66
2.5 Heparan sulfate design: regulation of biosynthesis Dagmar S. Pikas, Anh-Tri Do, Audrey Deligny, Anders Dagälv and Lena Kjelle Requires Authentication Unlicensed Licensed Download PDF	84
2.6 Bone and skin disorders caused by a disturbance in the biosynthesis of chondroitin sulfate and dermatan sulfate Shuji Mizumoto and Kazuyuki Sugahara Requires Authentication Unlicensed Licensed Download PDF	98
2.7 Biological functions of branched N-glycans related to physiology and pathology of extracellular matrix Congxiao Gao, Kazuaki Ohtsubo, Jianguo Gu and Naoyuki Taniguchi Requires Authentication Unlicensed Licensed Download PDF	119
3 Proteoglycans: structure, pathobiology, and signaling
3.1 Introduction Liliana Schaefer Requires Authentication Unlicensed Licensed Download PDF	135
3.2 Aggrecan in skeletal development and regenerative medicine Anna Plaas, Daniel J. Gorski, Jennifer Velasco, Colton McNicols, Rebecca Bell, Vincent Wang and John Sandy Requires Authentication Unlicensed Licensed Download PDF	141
3.3 The pathobiology of versican Thomas N. Wight Requires Authentication Unlicensed Licensed Download PDF	154
3.4 The biology of perlecan and its bioactive modules Chris D. Willis, Liliana Schaefer and Renato V. Iozzo Requires Authentication Unlicensed Licensed Download PDF	171
3.5 Small leucine-rich proteoglycans: multifunctional signaling effectors Rosetta Merline, Madalina V. Nastase, Renato V. Iozzo and Liliana Schaefer Requires Authentication Unlicensed Licensed Download PDF	185
3.6 Structure and function of syndecans Csilla Pataki and John R. Couchman Requires Authentication Unlicensed Licensed Download PDF	197
3.7 The glypican family Jorge Filmus and Mariana Capurro Requires Authentication Unlicensed Licensed Download PDF	209
3.8 Serglycin proteoglycan: implications for thrombosis, inflammation, atherosclerosis, and metastasis Barbara P. Schick Requires Authentication Unlicensed Licensed Download PDF	221
4 Matrix Proteinases: biological significance in health and disease
4.1 Introduction Jan-Olof Winberg Requires Authentication Unlicensed Licensed Download PDF	235
4.2 Extracellular functions of cysteine proteases Harald Thidemann Johansen and Rigmor Solberg Requires Authentication Unlicensed Licensed Download PDF	239
4.3 Plasmin and the plasminogen activator system in health and disease Gunbjørg Svineng, Synnøve Magnussen and Elin Hadler-Olsen Requires Authentication Unlicensed Licensed Download PDF	261
4.4 Matrix metalloproteinase complexes and their biological significance Bodil Fadnes, Elin Hadler-Olsen, Ingebrigt Sylte, Lars Uhlin-Hansen and Jan-Olof Winberg Requires Authentication Unlicensed Licensed Download PDF	291
4.5 The ADAMTS family of metalloproteinases Hideaki Nagase Requires Authentication Unlicensed Licensed Download PDF	315
4.6 Proteinases in wound healing Mervi Toriseva and Veli-Matti Kähäri Requires Authentication Unlicensed Licensed Download PDF	343
4.7 Rock, paper, and molecular scissors: regulating the game of extracellular matrix homeostasis, remodeling, and inflammation Antoine Dufour and Christopher M. Overall Requires Authentication Unlicensed Licensed Download PDF	377
5 ECM cell surface receptors
5.1 Introduction Donald Gullberg Requires Authentication Unlicensed Licensed Download PDF	403
5.2 Integrin function in heart fibrosis: mechanical strain, transforming growth factor-beta 1 activation, and collagen glycation Boris Hinz and Christopher A. McCulloch Requires Authentication Unlicensed Licensed Download PDF	406
5.3 Cancer-associated fibroblast integrins as therapeutic targets in the tumor microenvironment Ning Lu, Cord Brakebusch and Donald Gullberg Requires Authentication Unlicensed Licensed Download PDF	432
5.4 Discoidin domain receptors: non-integrin collagen receptors on the move Antonio S. Rocca and Michelle P. Bendeck Requires Authentication Unlicensed Licensed Download PDF	451
5.5 Syndecans as receptors for pericellular molecules Xiaojie Xian, James R. Whiteford and John R. Couchman Requires Authentication Unlicensed Licensed Download PDF	467
5.6 CD44: a Sensor of tissue damage critical for restoring homeostasis Ellen Puré Requires Authentication Unlicensed Licensed Download PDF	484
6 Collagens: insights into the folding, assembly and functions
6.1 Introduction Ruggero Tenni Requires Authentication Unlicensed Licensed Download PDF	501
6.2 Trimerization domains in collagens: chain selection, folding initiation, and triple-helix stabilization Sergei P. Boudko and Hans Peter Bächinger Requires Authentication Unlicensed Licensed Download PDF	506
6.3 Structural basis of collagen missense mutations Anton V. Persikov and Barbara Brodsky Requires Authentication Unlicensed Licensed Download PDF	521
6.4 Roles and regulation of BMP1/Tolloid-like proteinases: collagen/matrix assembly, growth factor activation, and beyond Catherine Moali and David J. S. Hulmes Requires Authentication Unlicensed Licensed Download PDF	539
6.5 Supramolecular assembly of type I collagen Mario Raspanti Requires Authentication Unlicensed Licensed Download PDF	562
6.6 Collagen interactomes: mapping functional domains and mutations on fibrillar and network-forming collagens James D. San Antonio, J. Des Parkin, Judy Savige, Joseph P. R. O. Orgel and Olena Jacenko Requires Authentication Unlicensed Licensed Download PDF	575
6.7 Collagen-binding proteins Takako Sasaki Requires Authentication Unlicensed Licensed Download PDF	592
7 Emerging aspects in extracellular matrix pathobiology
7.1 Introduction Achilleas Theocharis Requires Authentication Unlicensed Licensed Download PDF	605
7.2 Extracellular matrix in breast cancer: permissive and restrictive influences emanating from the stroma Ida Pucci-Minafra Requires Authentication Unlicensed Licensed Download PDF	610
7.3 EMMPRIN/CD147: potential functions in tumor microenvironment and therapeutic target for human cancer Eric Huet, Eric E Gabison, Samia Mourah and Suzanne Menashi Requires Authentication Unlicensed Licensed Download PDF	626
7.4 Implication of hyaluronidases in cancer growth, metastasis, diagnosis, and treatment Irene-Eva Triantaphyllidou, Serafoula Filou, Helen Bouga, Constantine Kolliopoulos and Demitrios H. Vynios Requires Authentication Unlicensed Licensed Download PDF	639
7.5 Structure-function relationship of syndecan-1, with focus on nuclear translocation and tumor cell behavior Fang Zong, Ilona Kovalszky, Anders Hjerpe and Katalin Dobra Requires Authentication Unlicensed Licensed Download PDF	653
7.6 Serglycin: a novel player in the terrain of neoplasia Angeliki Korpetinou, Eleni Milia-Argeiti, Vassiliki Labropoulou and Achilleas Theocharis Requires Authentication Unlicensed Licensed Download PDF	677
7.7 Quantifying cell-ECM pathobiology in 3D Joseph S. Maffei and Muhammad H. Zaman Requires Authentication Unlicensed Licensed Download PDF	689
7.8 Diabetic foot infections Cecilia Rydén Requires Authentication Unlicensed Licensed Download PDF	703
8 Targeting tumor microenvironment at the ECM level
8.1 Introduction Nikos K. Karamanos Requires Authentication Unlicensed Licensed Download PDF	719
8.2 Targeting the tumor microenvironment in cancer progression Suniti Misra, Vincent C. Hascall, Nikos K. Karamanos, Roger R. Markwald and Shibnath Ghatak Requires Authentication Unlicensed Licensed Download PDF	723
8.3 Growth factor signaling and extracellular matrix Dragana Nikitovic, Harris Pratsinis, Aikaterini Berdiaki, Chrisostomi Gialeli, Dimitris Kletsas and George N. Tzanakakis Requires Authentication Unlicensed Licensed Download PDF	741
8.4 Targeting protein-glycan interactions at cell surface during EMT and hematogenous metastasis: consequences on tumor invasion and metastasis Mauro S. G. Pavao, Eliene O. Kozlowski and Felipe C.O.B. Teixeira Requires Authentication Unlicensed Licensed Download PDF	763
8.5 Pharmacological targeting of proteoglycans and metalloproteinases: an emerging aspect in cancer treatment Spyros S. Skandalis, Chrisostomi Gialeli, Nikos Afratis, Alexios J. Aletras, Theodore Tsegenidis, Achilleas D. Theocharis and Nikos K. Karamanos Requires Authentication Unlicensed Licensed Download PDF	785
8.6 Targeting syndecan shedding in cancer Ralph D. Sanderson and John R. Couchman Requires Authentication Unlicensed Licensed Download PDF	802
8.7 PG receptors with phosphatase action in cancer and angiogenesis Marina Koutsioumpa and Evangelia Papadimitriou Requires Authentication Unlicensed Licensed Download PDF	813
8.8 Heparanase, a multifaceted protein involved in cancer, chronic inflammation, and kidney dysfunction Israel Vlodavsky, Michael Elkin, Benito Casu, Jin-Ping Li, Ralph D. Sanderson and Neta Ilan Requires Authentication Unlicensed Licensed Download PDF	824
8.9 Delivery systems targeting cancer at the level of ECM Shibnath Ghatak, Vincent C. Hascall, Nikos K. Karamanos, Roger R. Markwald and Suniti Misra Requires Authentication Unlicensed Licensed Download PDF	855
Index Requires Authentication Unlicensed Licensed Download PDF	873

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Researchers in biochemistry, molecular and cellular biology, medicine, biotechnology, pharmaceutical industries
Pages
- Front matter: 50
- Main content: 888
Illustrations
- Coloured Illustrations: 160
- Tables: 60
Keywords: Biochemistry; Glycans; Collagens; Matrix; Metalloproteinases

eBook

Published: August 31, 2012
ISBN: 9783110258776

Hardcover

Published: August 17, 2012
ISBN: 9783110258769