Structural and Catalytic Roles of  Metal Ions in RNA

Published by De Gruyter 2011

Structural and Catalytic Roles of Metal Ions in RNA

Edited by: Astrid Sigel , Helmut Sigel and Roland K.O. Sigel

Volume 9 in the series Metal Ions in Life Sciences

https://doi.org/10.1515/9783110436648

Overview
Contents

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The discovery of ribozymes nearly 30 years ago triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in MILS 9. This book, written by 28 internationally recognized experts from 8 nations, provides a most up-to-date view and is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes in an authoritative and timely manner in 12 stimulating chapters, supported by nearly 1600 references, 13 tables, and 75 illustrations, mostly in color, metal ion-binding motifs, methods to detect and characterize metal ion-binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered.

With nearly 1600 references, 13 tables, and 75 illustrations.
Single chapters can be purchased.

Author information

Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.

Topics

Frontmatter Publicly Available Download PDF	I
Historical Development and Perspectives of the Series Metal Ions in Life Sciences Astrid Sigel, Helmut Sigel and Roland K. O. Sigel Requires Authentication Unlicensed Licensed Download PDF	V
Preface to Volume 9: Structural and Catalytic Roles of Metal Ions in RNA Requires Authentication Unlicensed Licensed Download PDF	VII
Contents Publicly Available Download PDF	XI
Contributors to Volume 9 Requires Authentication Unlicensed Licensed Download PDF	XVII
Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series Requires Authentication Unlicensed Licensed Download PDF	XXI
Contents of Volumes in the Metal Ions in Life Sciences Series Requires Authentication Unlicensed Licensed Download PDF	XXIII
1 Metal Ion Binding to RNA Pascal Auffinger, Neena Grover and Eric Westhof Requires Authentication Unlicensed Licensed Download PDF	1
2 Methods to Detect and Characterize Metal Ion Binding Sites in RNA Michèle C. Erat and Roland K. O. Sigel Requires Authentication Unlicensed Licensed Download PDF	37
3 Importance of Diffuse Metal Ion Binding to RNA Zhi-Jie Tan and Shi-Jie Chen Requires Authentication Unlicensed Licensed Download PDF	101
4 RNA Quadruplexes Kangkan Halder and Jörg S. Hartig Requires Authentication Unlicensed Licensed Download PDF	125
5 The Roles of Metal Ions in Regulation by Riboswitches Adrian R. Ferré-D’Amaré and Wade C. Winkler Requires Authentication Unlicensed Licensed Download PDF	141
6 Metal Ions: Supporting Actors in the Playbook of Small Ribozymes Alexander E. Johnson-Buck, Sarah E. McDowell and Nils G. Walter Requires Authentication Unlicensed Licensed Download PDF	175
7 Multiple Roles of Metal Ions in Large Ribozymes Daniela Donghi and Joachim Schnabl Requires Authentication Unlicensed Licensed Download PDF	197
8 The Spliceosome and Its Metal Ions Samuel E. Butcher Requires Authentication Unlicensed Licensed Download PDF	235
9 The Ribosome: A Molecular Machine Powered by RNA Krista Trappl and Norbert Polacek Requires Authentication Unlicensed Licensed Download PDF	253
10 Metal Ion Requirements in Artificial Ribozymes that Catalyze Aminoacylation and Redox Reactions Hiroaki Suga, Kazuki Futai and Koichiro Jin Requires Authentication Unlicensed Licensed Download PDF	277
11 Metal Ion Binding and Function in Natural and Artificial Small RNA Enzymes from a Structural Perspective Joseph E. Wedekind Requires Authentication Unlicensed Licensed Download PDF	299
12 Binding of Kinetically Inert Metal Ions to RNA: The Case of Platinum(II) Erich G. Chapman, Alethia A. Hostetter, Maire F. Osborn, Amanda L. Miller and Victoria J. DeRose Requires Authentication Unlicensed Licensed Download PDF	347
Subject Index Requires Authentication Unlicensed Licensed Download PDF	379

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Scientists in biochemistry, inorganic chemistry, molecular biology, medicinal chemistry, toxicology, and medicine.
Pages
- Front matter: 32
- Main content: 391
Illustrations
- Illustrations: 30
- Coloured Illustrations: 48
- Tables: 50
Keywords: Anorganische Chemie; Bioanorganische Chemie; Biochemie; Koordinationschemie

eBook

Published: July 24, 2015
ISBN: 9783110436648

Hardcover

Published: July 20, 2015
ISBN: 9783110442823