Volume 2 Biochemistry, Biosynthesis and Human Diseases

Published by De Gruyter 2017

Volume 2 Biochemistry, Biosynthesis and Human Diseases

With contributions by: Nunziata Maio, Patricia Dos Santos, Dennis Dean, Wayne Outten, Caryn Outten, Erin L. Mettert, Patricia Kiley, Andy Dancis, Wing Hang Tong, Silke Leimkühler, Kerstin Gari, Roland Lill, James Wohlschlegel, John Peters, Eric S. Boyd, Eric M. Shepard, Joan B. Broderick, Michael W.W. Adams and Hong Ye
Edited by: Tracey Rouault

Part of the multi-volume work Iron-Sulfur Clusters in Chemistry and Biology

https://doi.org/10.1515/9783110479850

Overview
Contents

About this book

This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.

Mechanisms of FeS cluster interaction with oxygen.

Overview of FeS protein synthesis in model organisms.

Relationship of FeS proteins role in human diseases and drug discovery.

Author information

Tracey Rouault, NIH Bethesda, Maryland, USA

Reviews

"[...] I have enjoyed reading this volume enormously. I believe that it is well balanced and there is very little redundancy between the different chapters, which nicely complement one another. In this respect one should congratulate the overall editor Tracey Rouault. I think it is a great contribution to the field of iron–sulfur proteins and a great tool for students to understand the broad significance of these reactions in biology. I strongly recommend that all groups interested in this field purchase it together with the first volume, it is a very good investment."
Jean-Pierre Jacquot in: Acta Cryst. (2018). D74, 381–382

Frontmatter Accessible Download PDF	i
Preface Requires Authentication Accessible Download PDF	v
Tracey A. Rouault biography Requires Authentication Accessible Download PDF	vii
Contents Requires Authentication Accessible Download PDF	ix
List of contributing authors Requires Authentication Accessible Download PDF	xix
1 A retrospective on the discovery of [Fe-S] cluster biosynthetic machineries in Azotobacter vinelandii Patricia C. Dos Santos and Dennis R. Dean Requires Authentication Accessible Download PDF	1
2 The ISC system and the different facets of Fe-S biology in bacteria Laurent Aussel, Sylvia Chareyre, Yohann Duverger, Benjamin Ezraty, Allison Huguenot, Pierre Mandin, Béatrice Py, Jordi Zamarreno and Frédéric Barras Requires Authentication Accessible Download PDF	31
3 A stress-responsive Fe-S cluster biogenesis system in bacteria – the suf operon of Gammaproteobacteria F. Wayne Outten Requires Authentication Accessible Download PDF	47
4 Sensing the cellular Fe-S cluster demand: a structural, functional, and phylogenetic overview of Escherichia coli IscR Erin L. Mettert, Nicole T. Perna and Patricia J. Kiley Requires Authentication Accessible Download PDF	75
5 Fe-S assembly in Gram-positive bacteria Patricia C. Dos Santos Requires Authentication Accessible Download PDF	97
6 Fe-S cluster assembly and regulation in yeast Debkumar Pain and Andrew Dancis Requires Authentication Accessible Download PDF	117
7 The role of Fe-S clusters in regulation of yeast iron homeostasis Caryn E. Outten Requires Authentication Accessible Download PDF	161
8 Biogenesis of Fe-S proteins in mammals Tracey Rouault Requires Authentication Accessible Download PDF	187
9 Delivery of iron-sulfur clusters to recipient proteins: the role of chaperone and cochaperone proteins Nunziata Maio and Tracey A. Rouault Requires Authentication Accessible Download PDF	205
10 Iron-sulfur proteins and human diseases Wing Hang Tong Requires Authentication Accessible Download PDF	227
11 Friedreich ataxia Simon A. B. Knight and Robert B. Wilson Requires Authentication Accessible Download PDF	307
12 Connecting the biosynthesis of the molybdenum cofactor, Fe-S clusters, and tRNA thiolation in humans Silke Leimkühler Requires Authentication Accessible Download PDF	319
13 Iron-sulphur proteins and genome stability Kerstin Gari Requires Authentication Accessible Download PDF	347
14 Eukaryotic iron-sulfur protein biogenesis and its role in maintaining genomic integrity Roland Lill, Marta A. Uzarska and James Wohlschlegel Requires Authentication Accessible Download PDF	369
15 DNA signaling by iron-sulfur cluster proteins Phillip L. Bartels, Elizabeth O’Brien and Jacqueline K. Barton Requires Authentication Accessible Download PDF	405
16 Iron-sulfur cluster assembly in plants Hong Ye Requires Authentication Accessible Download PDF	425
17 Origin and evolution of Fe-S proteins and enzymes Eric S. Boyd, Gerrit J. Schut, Eric M. Shepard, Joan B. Broderick, Michael W. W. Adams and John W. Peters Requires Authentication Accessible Download PDF	445
Index Requires Authentication Accessible Download PDF	463

(Deutsch)

Language: English
Publisher: De Gruyter
Edition: 2nd Edition
Audience: Researchers in inorganic, bioinorganic and biochemistry, molecular biology, medicine and pharmacology.
Pages
- Front matter: 21
- Main content: 470
Illustrations
- Illustrations: 15
- Coloured Illustrations: 100
- Tables: 10
Keywords: Bioinorganic Chemistry; Biochemistry; Iron-sulfur Clusters

eBook

Published: September 25, 2017
ISBN: 9783110479850

Hardcover

Published: September 25, 2017
ISBN: 9783110479393